Article
Endocrinology & Metabolism
Marta Garaulet, Jesus Lopez-Minguez, Hassan S. Dashti, Celine Vetter, Antonio Miguel Hernandez-Martinez, Millan Perez-Ayala, Juan Carlos Baraza, Wei Wang, Jose C. Florez, Frank A. J. L. Scheer, Richa Saxena
Summary: This study revealed that late eating combined with high levels of melatonin and carbohydrate intake impairs glucose tolerance, especially in carriers of the MTNR1B G-risk allele, due to defects in insulin secretion.
Article
Biochemistry & Molecular Biology
Cheryl M. Isherwood, Daan R. van der Veen, Hana Hassanin, Debra J. Skene, Jonathan D. Johnston
Summary: This study suggests that the human circadian system can anticipate large meals. It also demonstrates that the timing of a three-meal daily feeding pattern can synchronize with circadian rhythms. Furthermore, the research shows that glucose concentrations decrease before the first meal and hunger increases before the predicted meal times in the large meal group.
Review
Biochemical Research Methods
Hedda L. Boege, Mehreen Z. Bhatti, Marie-Pierre St-Onge
Summary: Disruption of circadian rhythms can lead to adverse metabolic consequences by affecting energy metabolism and appetite regulating hormones. Social and eating jetlag, which are prevalent in the general population, can result in later mealtimes and potentially contribute to weight gain. Adjusting meal timing based on individual circadian patterns may help reduce the burden of cardiometabolic diseases and aid in weight loss.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
Mohammed S. Albreiki, Benita Middleton, Shelagh M. Hampton
Summary: This study found that providing exogenous melatonin before an evening meal can improve glucose and lipid metabolism and reduce postprandial TAG levels.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Pei Xue, Xiao Tan, Jiafei Wu, Xiangdong Tang, Christian Benedict
Summary: The G risk allele in the melatonin receptor gene is associated with an increased risk of myocardial infarction in patients with type 2 diabetes, but does not significantly impact mortality outcomes.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ivana Skrlec, Zrinka Biloglav, Jasminka Talapko, Snjezana Dzijan, Danijela Daus-Sebedak, Vera Cesar
Summary: This study investigated the association between MTNR1B gene polymorphisms, chronotype, and susceptibility to myocardial infarction. The case-control study included 199 myocardial infarction patients and 198 control participants without previous cardiovascular diseases, who were genotyped for MTNR1B polymorphisms. Chi-square tests revealed no significant association between allele and genotype distribution in myocardial infarction patients and controls. Additionally, there was no association between MTNR1B polymorphisms and chronotype in myocardial infarction patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Elizabeth Culnan, Kathryn J. Reid, Phyllis C. Zee, Stephanie J. Crowley, Kelly G. Baron
Summary: The timing of the last meal relative to the dim light melatonin onset (DLMO) is associated with the number of meals consumed, feeding duration, carbohydrate intake, and sugar intake. Among individuals with a later DLMO, a shorter interval between the last meal and DLMO is related to higher BMI.
Review
Nutrition & Dietetics
Fatema Alkhulaifi, Charles Darkoh
Summary: Dietary patterns and habits play a crucial role in controlling metabolic syndrome risk factors; meal timing and frequency can impact metabolic outcomes.
Review
Nutrition & Dietetics
Shengjie Zhu, Prasanth Surampudi, Nancy T. Field, Maria Chondronikola
Summary: Hyperglycemia during pregnancy and gestational diabetes mellitus pose health risks for both mothers and offspring. Studies suggest that meal timing and nutrient distribution can impact glycemic control during pregnancy, with early food consumption and short-term fasting showing potential benefits. However, further research is needed to fully understand the effects and mechanisms involved in this relationship.
Review
Biochemistry & Molecular Biology
Fiona Louise Roberts, Luis Rodrigo Cataldo, Malin Fex
Summary: Recent studies have highlighted the important role of serotonin and melatonin as regulators of islet hormone secretion and glucose homeostasis. Dysregulated signaling of both amines is implicated in the development of type 2 diabetes mellitus. Serotonin plays a key role in islet cell physiology, while melatonin regulates circadian rhythm and nutrient metabolism.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Rodrigo Chamorro, Karen Basfi-fer, Bernardita Sepulveda, Rut Farias, Pamela Rojas, Fernando Carrasco, Juana Codoceo, Jorge Inostroza, Manuel Ruz
Summary: This study assessed the association between meal timing and diet composition and metabolic parameters in patients with type-2 diabetes. The results showed that increased energy intake late during the day was related to increased total food and daily energy intake. Conversely, a greater proportion of total carbohydrates eaten early in the day was related to lower total energy intake. These findings suggest that earlier food intake may play an important role in dietary and metabolic control in patients with type-2 diabetes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Food Science & Technology
Mai Hijikata, Mariko Higa, Takamasa Ichijo, Takahisa Hirose
Summary: This study compared plasma glucose levels in MTT and 75-g OGTT to identify factors predicting a need for insulin therapy in GDM. It found that PG levels at 30 min after MTT may be useful for identifying patients who need insulin therapy.
FOOD & NUTRITION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jing-Li Tao, Xuan Zhang, Jia-Qi Zhou, Cheng-Yu Li, Ming-Hui Yang, Zhao-Jun Liu, Liang-Liang Zhang, Shou-Long Deng, Lu Zhang, Ming Shen, Guo-Shi Liu, Hong-Lin Liu
Summary: The study demonstrated that melatonin could reduce apoptosis of granulosa cells under hypoxic conditions by decreasing ROS levels and increasing expression of antioxidant enzymes. The protective effect of melatonin was mediated through the MT-MTNR1B signaling pathway involving downstream kinase PKA.
Review
Nutrition & Dietetics
Marlene Lages, Renata Barros, Pedro Moreira, Maria P. Guarino
Summary: The mixed meal tolerance test (MMTT) is a recommended method for assessing abnormalities in glucose homeostasis. It provides a more accurate representation of the body's response to a typical meal and allows for early detection of metabolic changes.
Review
Nutrition & Dietetics
Rikako Yoshitake, Insung Park, Hitomi Ogata, Naomi Omi
Summary: There is a physiological link between sleep and eating, and insufficient sleep can lead to overeating and weight gain. This review examines the effects of dietary timing on sleep and energy metabolism, including time-restricted eating. Time-restricted eating affects the time course of energy metabolism but not total energy expenditure, and it can lead to decreased energy intake and body weight in free-living conditions.
Article
Hospitality, Leisure, Sport & Tourism
Lei Gao, Arlen Gaba, Peng Li, Richa Saxena, Frank A. J. L. Scheer, Oluwaseun Akeju, Martin K. Rutter, Kun Hu
Summary: This study found that the heart rate recovery (HRR) during exercise is associated with future risk for delirium in middle-to older-aged individuals. Those with lower HRR have a higher risk for developing delirium.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Endocrinology & Metabolism
Andrew W. McHill, Lindsey S. Brown, Andrew J. K. Phillips, Laura K. Barger, Marta Garaulet, Frank A. J. L. Scheer, Elizabeth B. Klerman
Summary: This study examined the relationship between the timing of energy intake and body composition based on mathematically modeled circadian timing and in-laboratory collected metrics. The findings suggest that the use of mathematically modeled circadian timing can provide similar results to in-laboratory measurements, which may be beneficial in time-based interventions.
Article
Biochemical Research Methods
Wei Wang, Robin K. Yuan, Jude F. Mitchell, Kirsi-Marja Zitting, Melissa A. St Hilaire, James K. Wyatt, Frank A. J. L. Scheer, Kenneth P. Wright, Emery N. Brown, Joseph M. Ronda, Elizabeth B. Klerman, Jeanne F. Duffy, Derk-Jan Dijk, Charles A. Czeisler
Summary: Circadian clocks drive cyclic variations in many aspects of physiology, but it is often important to quantify the relative contributions of these factors. Nathaniel Kleitman's forced desynchrony (FD) protocol was designed to assess endogenous circadian rhythmicity and to separate circadian from evoked components of daily rhythms.
Article
Clinical Neurology
Lei Gao, Peng Li, Nicole Gaykova, Xi Zheng, Chenlu Gao, Jacqueline M. Lane, Richa Saxena, Frank A. J. L. Scheer, Martin K. Rutter, Oluwaseun Akeju, Kun Hu
Summary: This study found a bidirectional link between delirium and dementia, suggesting that they may be mutually related. Furthermore, disturbances in the sleep-wake rhythm were associated with an increased risk of delirium and progression to dementia. These findings highlight the importance of sleep-wake rhythm in cognitive function.
ANNALS OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Jingyi Qian, Qian P. Xiao, Michael Walkup, Mace L. Coday, Melissa Erickson, Jessica M. Unick, John Jakicic, Kun Hu, Frank A. J. L. Scheer, Roeland J. W. Middelbeek, Look AHEAD Res Grp
Summary: This study aimed to determine the association of the time-of-day of bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic control in adults with overweight/obesity and type 2 diabetes. The study found that bMVPA performed in the afternoon is associated with improvements in glycemic control, especially within the initial 12 months of an intervention.
Article
Endocrinology & Metabolism
Aviva Y. Cohn, Leilah K. Grant, Margo D. Nathan, Aleta Wiley, Mathena Abramson, Jessica A. Harder, Sybil Crawford, Elizabeth B. Klerman, Frank A. J. L. Scheer, Ursula B. Kaiser, Shadab A. Rahman, Hadine Joffe
Summary: This study investigated the effects of menopause-related sleep disturbance and estradiol decline on cortisol levels in healthy young women. The results showed that sleep fragmentation increased bedtime cortisol levels and decreased cortisol awakening response. Furthermore, suppression of estradiol also decreased bedtime cortisol levels. These findings suggest that menopause-related sleep disturbance and estradiol decline can negatively affect the activity of the hypothalamic-pituitary-adrenal axis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Marta Garaulet, Barbara Vizmanos, Teresa Muela, Alejandra Betancourt-Nunez, Maria-angeles Bonmati-Carrion, Celine Vetter, Hassan S. Dashti, Richa Saxena, Frank A. J. L. Scheer
Summary: This study aimed to investigate the relationship between being an evening type and reporting emotional eating behaviors. The results showed that evening types had higher scores on emotional eating and were more likely to be emotional eaters. They also scored higher on disinhibition/overeating and food craving factors. A meta-analysis revealed that being an evening type was associated with a higher score on emotional eating. Furthermore, individuals with late dim-light melatonin onset showed higher scores on emotional eating.
Article
Endocrinology & Metabolism
Barbara Vizmanos, Ana Isabel Cascales, Maria Rodriguez-Martin, Diego Salmeron, Eva Morales, Aurora Aragon-Alonso, Frank A. J. L. Scheer, Marta Garaulet
Summary: This study aimed to investigate the association between siestas and obesity, considering siesta duration and whether siesta traits and/or lifestyle factors mediate this association. The results showed that long siestas were associated with higher BMI, waist circumference, fasting glucose, blood pressure, and increased prevalence of MetS. However, short siestas were associated with a lower probability of elevated blood pressure. Various factors, including smoking, sleep and eating schedules, energy intake, and siesta location, mediated the association of siestas with obesity and MetS.
Article
Clinical Neurology
Rudy W. Chen, Ma Cherrysse Ulsa, Peng Li, Chenlu Gao, Xi Zheng, Jiawei Xu, Yong Luo, Shiqian Shen, Jacqueline Lane, Frank A. J. L. Scheer, Kun Hu, Lei Gao
Summary: This study investigates the association between sleep behavior and opioid-related adverse events (OAEs), finding that short or long sleep duration, frequent daytime sleepiness, insomnia symptoms, and napping are associated with an increased risk of OAEs.
Article
Endocrinology & Metabolism
Carolina Zambrano, Agne Kulyte, Juan Lujan, Belen Rivero-Gutierrez, Fermin Sanchez de Medina, Olga Martinez-Augustin, Mikael Ryden, Frank A. J. L. Scheer, Marta Garaulet
Summary: Habitual napping may disrupt circadian expression patterns of lipase E gene, resulting in impaired lipid mobilization and increased abdominal obesity in nappers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jingyi Qian, Christopher J. J. Morris, Rosanna Caputo, Frank A. J. L. Scheer
Summary: This study examined the impact of circadian misalignment in chronic shift workers and found that it increased ghrelin levels and hunger. However, it did not significantly affect energy expenditure or respiratory exchange ratio.
Review
Sport Sciences
Fabienne Bruggisser, Raphael Knaier, Ralf Roth, Wei Wang, Jingyi Qian, Frank A. J. L. Scheer
Summary: This systematic review and meta-analysis aimed to investigate whether the timing of exercise training in intervention studies affects the degree of improvements in physical performance or health-related outcomes. The results indicate that there is little evidence supporting the hypothesis that training at a specific time of day leads to more improvements compared to other times. However, there is some evidence that training and testing at the same time of day may have a benefit, particularly for performance-related outcomes.
SPORTS MEDICINE-OPEN
(2023)
Article
Biology
H. Craig Heller, Erik Herzog, Allison Brager, Gina Poe, Ravi Allada, Frank Scheer, Mary Carskadon, Horacio O. de la Iglesia, Rockelle Jang, Ashley Montero, Kenneth Wright, Philippe Mouraine, Matthew P. Walker, Namni Goel, John Hogenesch, Russell N. Van Gelder, Lance Kriegsfeld, Cheri Mah, Christopher Colwell, Jamie Zeitzer, Michael Grandner, Chandra L. Jackson, J. Roxanne Prichard, Steve A. Kay, Ketema Paul
Summary: Collegiate athletes face various pressures, including academic obligations, performance impact, health issues, and extensive travel. East-west travel disrupts circadian rhythms and affects sleep quality and health. To address these concerns, we provide suggestions and steps such as bedtime protocols, afternoon naps, and adherence to lighting exposure protocols, and encourage collaboration between athletic departments and experts to promote the health and wellbeing of athletes and staff.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
