The Role of Hypoxia-Inducible Factor-1 Alpha in Renal Disease

MiRNA-21- HIF-1α-VEGF Axis is Associated with Myopic Choroidal Neovascularization in Guinea Pigs

(2022) Lin Liu et al.   OPHTHALMIC RESEARCH

MicroRNA-122-5p ameliorates tubular injury in diabetic nephropathy via FIH-1/HIF-1α pathway

(2022) Li Cheng et al.   RENAL FAILURE

Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling

(2022) Huamei Wei et al.   Cell Death & Disease

Renal blood flow and oxygenation

(2022) Aurelie Edwards et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hypoxia and chronic kidney disease

(2022) Bin Wang et al.   EBioMedicine

Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α

(2022) Federica Cirillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanisms of Sanguinarine in cancer prevention and treatment

(2022) Asmat Ullah et al.   Anti-Cancer Agents in Medicinal Chemistry

Traditional Chinese Medicine Fufang-Zhenzhu-Tiaozhi capsule prevents renal injury in diabetic minipigs with coronary heart disease

(2022) Lixia Song et al.   Chinese Medicine

Treatment of Diabetic Kidney Disease: Current and Future

(2021) Tomotaka Yamazaki et al.   Diabetes & Metabolism Journal

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

(2021) Xiaomeng Feng et al.   Frontiers in Endocrinology

Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer

(2021) Asmat Ullah et al.   Cell Death & Disease

Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

(2021) Fengzhi Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats

(2021) Pierre E. Signore et al.   PLoS One

VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway

(2021) Ying Tong et al.   Cell Death & Disease

SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling

(2021) Jiangyi Wang et al.   Cell Death & Disease

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

(2021) Shen-Han Lee et al.   Cells

Lipocalin-2: Structure, function, distribution and role in metabolic disorders

(2021) Saeeda Al Jaberi et al.   BIOMEDICINE & PHARMACOTHERAPY

Dieckol Reduces Muscle Atrophy by Modulating Angiotensin Type II Type 1 Receptor and NADPH Oxidase in Spontaneously Hypertensive Rats

(2021) Seyeon Oh et al.   Antioxidants

Stabilizing HIF to Ameliorate Anemia

(2020) Richard A. Voit et al.   CELL

Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice

(2020) Mai Sugahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway

(2020) Zhan Gao et al.   MEDICAL SCIENCE MONITOR

The journey from erythropoietin to 2019 Nobel Prize: Focus on hypoxia-inducible factors in the kidney

(2020) Szu-Yu Pan et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF‑1α and apoptosis

(2020) Wangnan Sun et al.   Molecular Medicine Reports

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

(2020) Zong-Jie Fu et al.   Redox Biology

The Role of HIF in Immunity and Inflammation

(2020) Anne F. McGettrick et al.   Cell Metabolism

HIF‐1α ameliorates tubular injury in diabetic nephropathy via HO‐1–mediated control of mitochondrial dynamics

(2020) Na Jiang et al.   CELL PROLIFERATION

TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy

(2020) Hanxu Zeng et al.   INFLAMMATION RESEARCH

The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor

(2020) Yiren Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

(2020) Rouven Hoefflin et al.   Nature Communications

Integration of Lipidomics and Transcriptomics Reveals Reprogramming of the Lipid Metabolism and Composition in Clear Cell Renal Cell Carcinoma

(2020) Giuseppe Lucarelli et al.   Metabolites

Primary endothelial–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia

(2019) Rafal Bartoszewski et al.   FASEB JOURNAL

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

(2019) Najah Albadari et al.   Expert Opinion on Drug Discovery

Hypoxia signaling in human diseases and therapeutic targets

(2019) Jae W. Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Necrostatin-1 attenuates renal ischemia/reperfusion injury by inhibiting necroptosis, oxidative stress, and inflammation via mediation of HIF-1α/miR-26a/TRPC6/PARP1 signaling

(2019) Bingbing Shen et al.   Molecular Therapy-Nucleic Acids

What Makes the Kidney Susceptible to Hypoxia?

(2019) Roger G. Evans et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Identification of Hub Genes and Pathways in a Rat Model of Renal Ischemia-Reperfusion Injury Using Bioinformatics Analysis of the Gene Expression Omnibus (GEO) Dataset and Integration of Gene Expression Profiles

(2019) Ao Guo et al.   MEDICAL SCIENCE MONITOR

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling

(2018) Ailing Li et al.   Cell Death & Disease

Lipocalin-2 protects against renal ischemia/reperfusion injury in mice through autophagy activation mediated by HIF1α and NF-κb crosstalk

(2018) Shujuan Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

A Dual Role of Heme Oxygenase-1 in Cancer Cells

(2018) Shih-Kai Chiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A protective role for microRNA-688 in acute kidney injury

(2018) Nicholas Chun et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal Protection Mediated by Hypoxia Inducible Factor-1α Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1

(2017) Xialian Xu et al.   TRANSPLANTATION

Unilateral Partial Nephrectomy with Warm Ischemia Results in Acute Hypoxia Inducible Factor 1-Alpha (HIF-1α) and Toll-Like Receptor 4 (TLR4) Overexpression in a Porcine Model

(2016) Zhiyong Zhang et al.   PLoS One

TNF-α-Induced NF-κB Activation Stimulates Skeletal Muscle Glycolytic Metabolism Through Activation of HIF-1α

(2015) A. H. V. Remels et al.   ENDOCRINOLOGY

Vascular nitric oxide: Beyond eNOS

(2015) Yingzi Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Anaemia in kidney disease: harnessing hypoxia responses for therapy

(2015) Mark J. Koury et al.   Nature Reviews Nephrology

HO-1/CO system in tumor growth, angiogenesis and metabolism — Targeting HO-1 as an anti-tumor therapy

(2015) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

Deletion of Hypoxia-Inducible Factor-1α in Adipocytes Enhances Glucagon-Like Peptide-1 Secretion and Reduces Adipose Tissue Inflammation

(2014) Yoshitaka Kihira et al.   PLoS One

Effect of acute environmental hypoxia on protein metabolism in human skeletal muscle

(2013) G. D'Hulst et al.   Acta Physiologica

Epigenetic regulation in RCC: opportunities for therapeutic intervention?

(2012) James Larkin et al.   Nature Reviews Urology

Phosphodiesterase Inhibitor Improves Renal Tubulointerstitial Hypoxia of the Diabetic Rat Kidney

(2012) Hui-Kyoung Sun et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis

(2011) Federico A Monzon et al.   MODERN PATHOLOGY

Mapping complex disease traits with global gene expression

(2009) William Cookson et al.   NATURE REVIEWS GENETICS

Adaptation to hypoxia in the diabetic rat kidney

(2007) C. Rosenberger et al.   KIDNEY INTERNATIONAL