Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

(2022) Chen Zhang et al.   Molecular Cancer

In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica

(2022) Franziska M. Jürgens et al.   Metabolites

Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis

(2022) Michał Kosno et al.   MOLECULES

The Nitrogen Mustards

(2022) Martin S. Highley et al.   PHARMACOLOGICAL REVIEWS

Delphinidin Increases the Sensitivity of Ovarian Cancer Cell Lines to 3-bromopyruvate

(2021) Natalia Pieńkowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions

(2021) Agnieszka Potęga et al.   Journal of Pharmaceutical Analysis

Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells

(2021) Anna Mieszkowska et al.   Pharmaceuticals

Mechanisms of Multidrug Resistance in Cancer Chemotherapy

(2020) Karol Bukowski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents

(2020) Jiabei Zhou et al.   Frontiers in Pharmacology

Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes

(2020) Ewa Paluszkiewicz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer

(2020) Matthias Piesche et al.   Frontiers in Pharmacology

Role of Glutathione in Cancer: From Mechanisms to Therapies

(2020) Luke Kennedy et al.   Biomolecules

Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment

(2019) Tengjiao Fan et al.   Cancers

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

(2019) Jennifer Yinuo Cao et al.   Cell Reports

Binding motifs of cisplatin interaction with simple biomolecules and aminoacid targets probed by IR ion spectroscopy

(2019) Davide Corinti et al.   PURE AND APPLIED CHEMISTRY

A Phase 1/2 Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed/ Refractory Acute Myeloid Leukemia

(2019) Anjali Advani et al.   CLINICAL CANCER RESEARCH

The role of thiols in antioxidant systems

(2019) Kathrin Ulrich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin

(2019) Yogesh Rai et al.   BIOSCIENCE REPORTS

Novel insights into the mechanism of cyclophosphamide-induced bladder toxicity: chloroacetaldehyde’s contribution to urothelial dysfunction in vitro

(2019) Kylie A. Mills et al.   ARCHIVES OF TOXICOLOGY

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy

(2019) Enrico Desideri et al.   Nutrients

Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives

(2018) Rajesh K. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

(2018) Giancarlo Aldini et al.   FREE RADICAL RESEARCH

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

Bioanalysis of ibrutinib, and its dihydrodiol- and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry

(2018) J.J.M. Rood et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma

(2018) Milind Javle et al.   JOURNAL OF CLINICAL ONCOLOGY

Concerted nucleophilic aromatic substitutions

(2018) Eugene E. Kwan et al.   Nature Chemistry

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Cabozantinib Versus Mitoxantrone-prednisone in Symptomatic Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 3 Trial with a Primary Pain Endpoint

(2018) Ethan M. Basch et al.   EUROPEAN UROLOGY

Metabolism and Bioactivation of Corynoline With Characterization of the Glutathione/Cysteine Conjugate and Evaluation of Its Hepatotoxicity in Mice

(2018) Ruijuan Liu et al.   Frontiers in Pharmacology

Cisplatin nephrotoxicity: a review of the literature

(2017) Sandhya Manohar et al.   JOURNAL OF NEPHROLOGY

The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view

(2017) Salah Mohamed El Sayed et al.   MEDICAL HYPOTHESES

Spontaneous Production of Glutathione-Conjugated Forms of 1,2-Dichloropropane: Comparative Study on Metabolic Activation Processes of Dihaloalkanes Associated with Occupational Cholangiocarcinoma

(2017) Yu Toyoda et al.   Oxidative Medicine and Cellular Longevity

The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy

(2016) Martina Ahlmann et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Covalent DNA–Protein Cross-Linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells

(2016) Arnold Groehler et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

(2016) J. Azevedo-Silva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300

(2016) Anke Jakobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model

(2016) Davide Komla-Ebri et al.   JOURNAL OF CLINICAL INVESTIGATION

Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione

(2016) Izabela Sadowska-Bartosz et al.   Pharmacological Reports

Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma

(2016) Katarzyna Niedźwiecka et al.   Oncotarget

The busulfan metabolite EdAG irreversibly glutathionylates glutaredoxins

(2015) Michele Scian et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Targeting glycolysis by 3-bromopyruvate improves tamoxifen cytotoxicity of breast cancer cell lines

(2015) Yasmin M. Attia et al.   BMC CANCER

Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins

(2015) Vladimir L. Rusinov et al.   Chemistry of Heterocyclic Compounds

Mitoxantrone, More than Just Another Topoisomerase II Poison

(2015) Benny J. Evison et al.   MEDICINAL RESEARCH REVIEWS

N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine induces mitochondrial-mediated apoptosis and suppresses migration in melanoma cells

(2015) WEI CHEN et al.   ONCOLOGY REPORTS

Unbalanced Activation of Glutathione Metabolic Pathways Suggests Potential Involvement in Plant Defense against the Gall Midge Mayetiola destructor in Wheat

(2015) Xuming Liu et al.   Scientific Reports

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Phase 0 and phase III transport in various organs: Combined concept of phases in xenobiotic transport and metabolism

(2014) Barbara Döring et al.   DRUG METABOLISM REVIEWS

Metabolism of cisplatin in the organs of Rattus norvegicus: role of Glutathione S-transferase P1

(2014) Ritika Nagar et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Past, present and future role of chlorambucil in the treatment of chronic lymphocytic leukemia

(2014) Valentin Goede et al.   LEUKEMIA & LYMPHOMA

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

(2014) Salah Mohamed El Sayed et al.   Chinese Journal of Cancer

Glutathione S-conjugates as prodrugs to target drug-resistant tumors

(2014) Emma E. Ramsay et al.   Frontiers in Pharmacology

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity

(2013) Luciana Grazziotin Rossato et al.   ARCHIVES OF TOXICOLOGY

The Interaction of the Chemotherapeutic Drug Chlorambucil with Human Glutathione Transferase A1-1: Kinetic and Structural Analysis

(2013) Michael Karpusas et al.   PLoS One

Glutathione Transferase (GST)-Activated Prodrugs

(2013) Paolo Ruzza et al.   Pharmaceutics

Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes

(2012) Marcel Deponte   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death

(2012) Chuan Bian Lim et al.   BMC Complementary and Alternative Medicine

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Results of a Randomized Trial of Chlorambucil Versus Fludarabine for Patients With Untreated Waldenström Macroglobulinemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma

(2012) Véronique Leblond et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of pharmacogenetics in busulfan/cyclophosphamide conditioning therapy prior to hematopoietic stem cell transplantation

(2012) Moustapha Hassan et al.   PHARMACOGENOMICS

DFT study on Thiotepa and Tepa interactions with their DNA receptor

(2012) Hedieh Torabifard et al.   STRUCTURAL CHEMISTRY

Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?

(2012) Angela Casini et al.   Chemical Science

S-Glutathionylation: From Molecular Mechanisms to Health Outcomes

(2011) Ying Xiong et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

(2011) Vito Guagnano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC–ESI-QTOFMS-based metabolomics

(2010) Fei Li et al.   BIOCHEMICAL PHARMACOLOGY

Glutathione Pathway Genetic Polymorphisms and Lung Cancer Survival After Platinum-Based Chemotherapy

(2010) A. M. Moyer et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Prediction of Michael-Type Acceptor Reactivity toward Glutathione

(2010) Johannes A. H. Schwöbel et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO

(2010) Steven Hutchens et al.   INVESTIGATIONAL NEW DRUGS

Pharmacokinetic targeting of intravenous busulfan reduces conditioning regimen related toxicity following allogeneic hematopoietic cell transplantation for acute myelogenous leukemia

(2010) Joseph Pidala et al.   Journal of Hematology & Oncology

Deleterious Effects of Reactive Metabolites

(2010) Sabry M. Attia   Oxidative Medicine and Cellular Longevity

Structure-based design of anticancer prodrug PABA/NO

(2010) Xinhua Ji   Drug Design Development and Therapy

Glutathione dysregulation and the etiology and progression of human diseases

(2009) Nazzareno Ballatori et al.   BIOLOGICAL CHEMISTRY

Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway

(2009) H-A Park et al.   CELL DEATH AND DIFFERENTIATION

Platinum Drug Distribution in Cancer Cells and Tumors

(2009) Alice V. Klein et al.   CHEMICAL REVIEWS

Inhibition of transcription by platinum antitumor compounds

(2009) Ryan C. Todd et al.   Metallomics

Glutathione and apoptosis

(2008) Magdalena L. Circu et al.   FREE RADICAL RESEARCH

The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants

(2008) Lorien J. Parker et al.   JOURNAL OF MOLECULAR BIOLOGY

Dehydroalanine Analog of Glutathione: An Electrophilic Busulfan Metabolite That Binds to Human Glutathione S-Transferase A1-1

(2008) I. R. Younis et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin

(2008) Corine Ekhart et al.   Pharmacogenetics and Genomics

Structural Determinants of Glutathione Transferases with Azathioprine Activity Identified by DNA Shuffling of Alpha Class Members

(2007) Sanela Kurtovic et al.   JOURNAL OF MOLECULAR BIOLOGY