Ascorbate Is a Primary Antioxidant in Mammals

Superoxide Radicals in the Execution of Cell Death

(2022) Junichi Fujii et al.   Antioxidants

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

(2022) Brent R. Stockwell   CELL

The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency

(2022) Soju Kimura et al.   LIFE SCIENCES

The role of vitamin C in epigenetic cancer therapy

(2021) Stine Ulrik Mikkelsen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels

(2021) Naoki Ishii et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Vitamin C Deficiency Inhibits Nonalcoholic Fatty Liver Disease Progression through Impaired de Novo Lipogenesis

(2021) Seoung-Woo Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Vitamin C (Ascorbate) and Redox Topics in Cancer

(2021) Christophe Glorieux et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

(2021) Claudia Lennicke et al.   MOLECULAR CELL

Glutaredoxin: Discovery, redox defense and much more

(2021) Fernando T. Ogata et al.   Redox Biology

Epigenetics of Most Aggressive Solid Tumors: Pathways, Targets and Treatments

(2021) Javier Martinez-Useros et al.   Cancers

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

(2021) Shen-Han Lee et al.   Cells

Vitamin C Enhances Antiviral Functions of Lung Epithelial Cells

(2021) Trevor Teafatiller et al.   Biomolecules

Pleiotropic Actions of Aldehyde Reductase (AKR1A)

(2021) Junichi Fujii et al.   Metabolites

Vitamin C alleviates alcoholic liver injury by suppressing neutrophil infiltration in senescence marker protein 30-knockout mice irrespective of its antioxidant effects

(2021) Su-Min Baek et al.   LIFE SCIENCES

Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?

(2021) Léonce Kouakanou et al.   Frontiers in Immunology

Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer

(2021) Changjian Shao et al.   Translational Lung Cancer Research

The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review

(2021) Marcelo Villagran et al.   Antioxidants

Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway

(2020) Miku Takahashi et al.   LIFE SCIENCES

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

(2020) Rebecca A. Luchtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

(2020) Maira Di Tano et al.   Nature Communications

Vitamin C and Cell Death

(2020) András Szarka et al.   ANTIOXIDANTS & REDOX SIGNALING

Reduction of sulfenic acids by ascorbate in proteins, connecting thiol-dependent to alternative redox pathways

(2020) Valesca Anschau et al.   FREE RADICAL BIOLOGY AND MEDICINE

Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue

(2020) Takujiro Homma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice

(2020) Gyul Moon et al.   FREE RADICAL RESEARCH

Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression

(2020) Dandan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascorbate deficiency decreases dopamine release in gulo –/– and APP/PSEN1 mice

(2020) David C. Consoli et al.   JOURNAL OF NEUROCHEMISTRY

Ascorbic acid prevents N-nitrosodiethylamine-induced hepatic injury and hepatocarcinogenesis in Akr1a-knockout mice

(2020) Naoki Ishii et al.   TOXICOLOGY LETTERS

Radiation-induced gastrointestinal syndrome is exacerbated in vitamin C–insufficient SMP30/GNL knockout mice

(2020) Reina Saga et al.   NUTRITION

Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver

(2020) Kenichi Kawahori et al.   Scientific Reports

Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory

(2019) Keita Takahashi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dietary ascorbic acid restriction in GNL/SMP30-knockout mice unveils the role of ascorbic acid in regulation of somatic and visceral pain sensitivity

(2019) Maho Tsubota et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple independent L-gulonolactone oxidase (GULO) gene losses and vitamin C synthesis reacquisition events in non-Deuterostomian animal species

(2019) Sílvia F. Henriques et al.   BMC EVOLUTIONARY BIOLOGY

Vitamin C promotes the proliferation and effector functions of human γδ T cells

(2019) Léonce Kouakanou et al.   Cellular & Molecular Immunology

The Clinical Spectrum of PTEN Mutations

(2019) Lamis Yehia et al.   Annual Review of Medicine

Ascorbic acid and CoQ10 ameliorate the reproductive ability of SOD1-deficient female mice

(2019) Naoki Ishii et al.   BIOLOGY OF REPRODUCTION

High dietary vitamin C intake reduces glucocorticoid-induced immunosuppression and measures of oxidative stress in vitamin C-deficient senescence marker protein-30 knockout mice

(2019) Ryusei Uchio et al.   BRITISH JOURNAL OF NUTRITION

The Pharmacokinetics of Vitamin C

(2019) Jens Lykkesfeldt et al.   Nutrients

Tumor Necrosis Factor alpha (TNF-α) reduces intestinal vitamin C uptake: a role for NF-κB mediated signaling

(2018) Veedamali S Subramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

(2018) Louise Hecker   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vitamin C deficiency aggravates tumor necrosis factor α-induced insulin resistance

(2018) Zhou Qing et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ascorbic acid metabolism and functions: A comparison of plants and mammals

(2018) Nicholas Smirnoff   FREE RADICAL BIOLOGY AND MEDICINE

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

(2018) Takujiro Homma et al.   TOXICOLOGY LETTERS

Vitamin C in Stem Cell Reprogramming and Cancer

(2018) Luisa Cimmino et al.   TRENDS IN CELL BIOLOGY

Oxidative Stress Levels in the Brain Are Determined by Post-Mortem Interval and Ante-Mortem Vitamin C State but Not Alzheimer’s Disease Status

(2018) Jared Eckman et al.   Nutrients

Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity

(2018) Jieun Choo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

(2018) Niraj Shenoy et al.   CANCER CELL

Ascorbate and ferritin interactions: consequences for iron release in vitro and in vivo and implications for inflammation

(2018) Charles Badu-Boateng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury

(2018) Hua-Lin Zhou et al.   NATURE

Oxidatively generated base modifications in DNA: Not only carcinogenic risk factor but also regulatory mark?

(2017) Marco Seifermann et al.   FREE RADICAL BIOLOGY AND MEDICINE

UDP-glucuronosyltransferases (UGTs) and their related metabolic cross-talk with internal homeostasis: A systematic review of UGT isoforms for precision medicine

(2017) Na Yang et al.   PHARMACOLOGICAL RESEARCH

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice

(2017) Cheng-Wei Lai et al.   Oncotarget

Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo−/− mice

(2016) Lucie Aumailley et al.   Aging-US

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy

(2016) Toshihiro Kurahashi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress

(2016) Ryusuke Akihara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Skewing of peritoneal resident macrophages toward M1-like is involved in enhancement of inflammatory responses induced by secondary necrotic neutrophils in aged mice

(2016) Rei Takahashi et al.   CELLULAR IMMUNOLOGY

Senescence marker protein-30 deficiency impairs angiogenesis under ischemia

(2016) Hiroyuki Yamauchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

(2016) Elizabeth J. Campbell et al.   FREE RADICAL BIOLOGY AND MEDICINE

L-Ascorbic acid can abrogate SVCT-2-dependent cetuximab resistance mediated by mutant KRAS in human colon cancer cells

(2016) Soo-A. Jung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease

(2016) Yoshitaka Kondo et al.   Geriatrics & Gerontology International

Bone degeneration and its recovery in SMP30/GNL-knockout mice

(2016) Kazutoshi Nishijima et al.   Journal of Nutrition Health & Aging

Vitamin C impacts anxiety-like behavior and stress-induced anorexia relative to social environment in SMP30/GNL knockout mice

(2016) Miwako Koizumi et al.   NUTRITION RESEARCH

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation

(2016) Gibok Lee et al.   Scientific Reports

Vitamin C Deficiency Causes Severe Defects in the Development of the Neonatal Cerebellum and in the Motor Behaviors of Gulo−/− Mice

(2015) Hyemin Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatoprotective effect of vitamin C on lithocholic acid-induced cholestatic liver injury in Gulo(−/−) mice

(2015) Su Jong Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice

(2015) Rei Takahashi et al.   Geriatrics & Gerontology International

Revisiting vitamin C and cancer

(2015) C. R. Reczek et al.   SCIENCE

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Ascorbic acid deficiency affects genes for oxidation–reduction and lipid metabolism in livers from SMP30/GNL knockout mice

(2014) Keita Takahashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial ascorbic acid transport is mediated by a low-affinity form of the sodium-coupled ascorbic acid transporter-2

(2014) Carola Muñoz-Montesino et al.   FREE RADICAL BIOLOGY AND MEDICINE

Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction

(2014) H. Nishida et al.   FREE RADICAL RESEARCH

Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance

(2014) Kyung Jin Jung et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Senescence Marker Protein 30 Has a Cardio-Protective Role in Doxorubicin-Induced Cardiac Dysfunction

(2014) Makiko Miyata et al.   PLoS One

High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice

(2014) S-Y Kook et al.   Cell Death & Disease

Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes

(2014) Hiroshi Okada et al.   Journal of Diabetes Investigation

Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis

(2014) Yoshitaka Kondo et al.   FEBS Open Bio

Vitamin C Prevents Cigarette Smoke-Induced Pulmonary Emphysema in Mice and Provides Pulmonary Restoration

(2013) Kengo Koike et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-Inducible Factor 1 and Cardiovascular Disease

(2013) Gregg L. Semenza   Annual Review of Physiology

Coronary Artery Spasm Related to Thiol Oxidation and Senescence Marker Protein-30 in Aging

(2013) Shinya Yamada et al.   ANTIOXIDANTS & REDOX SIGNALING

In Vivo Consequence of Vitamin C Insufficiency in Liver Injury: Vitamin C Ameliorates T-Cell-Mediated Acute Liver Injury in Gulo(−/−) Mice

(2013) Seyeon Bae et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential responses of SOD1-deficient mouse embryonic fibroblasts to oxygen concentrations

(2013) Satoshi Tsunoda et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction

(2013) Tomofumi Misaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sulfenic acid chemistry, detection and cellular lifetime

(2013) Vinayak Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling

(2013) Tomofumi Misaka et al.   CARDIOVASCULAR RESEARCH

Breathing-in epigenetic change with vitamin C

(2013) Asun Monfort et al.   EMBO REPORTS

Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice

(2013) Akiko Amano et al.   EUROPEAN JOURNAL OF NUTRITION

Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-α, and ROS production in Gulo(−/−) mice

(2013) Hyemin Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic vitamin C insufficiency aggravated thioacetamide-induced liver fibrosis in gulo-knockout mice

(2013) Jin-Hee Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

(2013) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Ascorbic acid prevents protein oxidation in livers of senescence marker protein-30/gluconolactonase knockout mice

(2013) Yasunori Sato et al.   Geriatrics & Gerontology International

Increased Susceptibility of Radiation-Induced Intestinal Apoptosis in SMP30 KO Mice

(2013) Moon-Jung Goo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescence Marker Protein-30 (SMP30) Deficiency Impairs Myocardium-Induced Dilation of Coronary Arterioles Associated with Reactive Oxygen Species

(2013) Hiroyuki Mizukami et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Attenuation of Sepsis-Induced Organ Injury in Mice by Vitamin C

(2013) Bernard J. Fisher et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice

(2013) Junitsu Ito et al.   LIFE SCIENCES

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

Combined vitamin C and E deficiency induces motor defects in gulo−/−/SVCT2+/−mice

(2013) Marquicia R. Pierce et al.   NUTRITIONAL NEUROSCIENCE

Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice

(2013) Yuki Kishimoto et al.   PEDIATRIC RESEARCH

Leprdb/db Mice with Senescence Marker Protein-30 Knockout (Leprdb/dbSmp30Y/−) Exhibit Increases in Small Dense-LDL and Severe Fatty Liver Despite Being Fed a Standard Diet

(2013) Yoshitaka Kondo et al.   PLoS One

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation

(2013) Bassem Mohammed et al.   Nutrients

In vivo role of aldehyde reductase

(2012) Motoko Takahashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tolerance to nitroglycerin through proteasomal down-regulation of aldehyde dehydrogenase-2 in a genetic mouse model of ascorbate deficiency

(2012) G Wölkart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype ofGulo(−/−)knockout mice

(2012) Y. Chen et al.   GENES BRAIN AND BEHAVIOR

Depletion of ascorbic acid impairs NK cell activity against ovarian cancer in a mouse model

(2012) Jee-Eun Kim et al.   IMMUNOBIOLOGY

Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice

(2012) JOHN CHA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Behavioral and monoamine changes following severe vitamin C deficiency

(2012) Margaret S. Ward et al.   JOURNAL OF NEUROCHEMISTRY

Recent Applications of Engineered Animal Antioxidant Deficiency Models in Human Nutrition and Chronic Disease

(2012) Rosemary Yu et al.   JOURNAL OF NUTRITION

SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment

(2012) S-W Hong et al.   ONCOGENE

Vitamin C is dispensable for oxygen sensing in vivo

(2011) K. J. Nytko et al.   BLOOD

The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

(2011) Tao Wang et al.   Cell Stem Cell

The Genetics of Vitamin C Loss in Vertebrates

(2011) Guy Drouin et al.   CURRENT GENOMICS

Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice

(2011) Yohei Ishikawa et al.   EXPERIMENTAL EYE RESEARCH

Vitamins C and E: Beneficial effects from a mechanistic perspective

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic profiling of vitamin C deficiency in Gulo−/− mice using proton NMR spectroscopy

(2011) Gavin E. Duggan et al.   JOURNAL OF BIOMOLECULAR NMR

Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice

(2011) Takafumi Senmaru et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Suppression of CFTR-mediated Cl- Secretion of Airway Epithelium in Vitamin C-deficient Mice

(2011) Yeryung Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Vitamin C for DNA damage prevention

(2011) Radim J. Sram et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice

(2011) Kazimierz S. Kasprzak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice

(2010) Kengo Koike et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice

(2010) Akiko Amano et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Low ascorbic acid and increased oxidative stress in gulo(−/−) mice during development

(2010) Fiona E. Harrison et al.   BRAIN RESEARCH

Vitamin C distribution and retention in the mouse brain

(2010) Fiona E. Harrison et al.   BRAIN RESEARCH

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

(2010) Miguel Angel Esteban et al.   Cell Stem Cell

Ascorbate Synthesis Pathway

(2010) Kenneth H. Gabbay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice

(2010) Christopher P. Corpe et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice

(2010) Jin-Kyu Park et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation

(2010) Mi-Ran Ki et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Time course of vitamin C distribution and absorption after oral administration in SMP30/GNL knockout mice

(2010) Mizuki Iwama et al.   NUTRITION

Molecular Delineation of γ-Ray-Induced NF-κB Activation and Pro-inflammatory Genes in SMP30 Knockout Mice

(2010) Sang Woon Chung et al.   RADIATION RESEARCH

Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice

(2009) Akinori Kashio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of vitamin C deficiency on the skin of the senescence marker protein-30 (SMP30) knockout mouse

(2009) Koji Y. Arai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Over-expression of Senescence Marker Protein-30 Decreases Reactive Oxygen Species in Human Hepatic Carcinoma Hep G2 Cells

(2009) Setsuko Handa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Senescence Marker Protein-30/Gluconolactonase Deletion Worsens Glucose Tolerance through Impairment of Acute Insulin Secretion

(2009) Goji Hasegawa et al.   ENDOCRINOLOGY

Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2

(2009) Fiona E. Harrison et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice

(2009) Jin-Kyu Park et al.   HEPATOLOGY

Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice

(2009) F.E. Harrison et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice

(2008) Yoshitaka Kondo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice

(2008) Yasunori Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin C Is Not Essential for Carnitine Biosynthesis in Vivo: Verification in Vitamin C-Depleted Senescence Marker Protein-30/Gluconolactonase Knockout Mice

(2008) Hajime Furusawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid

(2008) Fiona E. Harrison et al.   JOURNAL OF NEUROCHEMISTRY

The Na+-dependent l-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids

(2008) Teresa Caprile et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Radiation-Induced Apoptosis via Overexpression of SMP30 in Smad3-Knockout Mice Liver

(2008) Da-Hee JEONG et al.   JOURNAL OF RADIATION RESEARCH

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knock-out mice

(2008) Jin-Kyu Park et al.   TOXICOLOGY