Article
Agronomy
Mohammad Reza Fayezizadeh, Naser Alemzadeh Ansari, Mohammad Mahmoodi Sourestani, Mirza Hasanuzzaman
Summary: The appropriate concentration of nutrient solution significantly affects the yield, antioxidant capacity, and biochemical compounds of basil microgreens in a floating system. Results showed that a 50% NS concentration led to the highest yield, while a 125% NS concentration resulted in the highest content of secondary metabolites with enhanced antioxidant capacity. A 100% NS concentration provided a balance between antioxidant properties and yield.
Article
Biochemistry & Molecular Biology
Trevor Teafatiller, Sudhanshu Agrawal, Gabriela De Robles, Farah Rahmatpanah, Veedamali S. Subramanian, Anshu Agrawal
Summary: Vitamin C exerts its antiviral and protective functions in the lungs by upregulating metabolic pathways and interferon-stimulated genes, while simultaneously downregulating pathways related to lung injury and inflammation. Additionally, vitamin C enhances the expression of viral-sensing receptors, contributing to its antiviral effects.
Review
Nutrition & Dietetics
Pernille Tveden-Nyborg
Summary: Severe and long-term vitamin C deficiency can lead to fatal scurvy, while a moderate deficiency may affect up to 10% of the Western population. The brain's high levels of vitamin C during deficiency suggest its importance, particularly during development, but research on non-scorbutic states of deficiency remains limited.
Article
Agriculture, Dairy & Animal Science
Yufei Zhu, Wei Guo, Jianfei Zhao, Kailong Qin, Jiakun Yan, Xinhuo Huang, Zhouzheng Ren, Xin Yang, Yanli Liu, Xiaojun Yang
Summary: The study showed that dietary VC supplementation can enhance VC absorption in the duodenum and magnum, but reduce endogenous VC synthesis in the liver and kidney, with positive effects on VC transportation in the ovary and magnum. However, it does not increase VC deposition in produced eggs.
Article
Oncology
Tiziana Ottone, Isabella Faraoni, Giorgio Fucci, Mariadomenica Divona, Serena Travaglini, Eleonora De Bellis, Francesco Marchesi, Daniela Francesca Angelini, Raffaele Palmieri, Carmelo Gurnari, Manuela Giansanti, Anna Maria Nardozza, Federica Montesano, Emiliano Fabiani, Elisa Linnea Lindfors Rossi, Raffaella Cerretti, Laura Cicconi, Marco De Bardi, Maria Luisa Catanoso, Luca Battistini, Renato Massoud, Adriano Venditti, Maria Teresa Voso
Summary: This study found that vitamin C levels are significantly lower in AML patients at the time of initial diagnosis, further decreasing during disease progression, and returning to normal upon achievement of complete remission. Additionally, vitamin C levels are significantly lower in AML cells compared to healthy cells. However, there is no association between vitamin C levels and the mutation profile, cytogenetics, or risk stratification of AML patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
H. B. Zhou, X. Y. Huang, Z. Bi, Y. H. Hu, F. Q. Wang, X. X. Wang, Y. Z. Wang, Z. Q. Lu
Summary: Vitamin A production requires antioxidants to prevent degradation, with Vitamin C sodium showing better antioxidant capacity in vitro. The study found that Vitamin C sodium Vitamin A significantly improved growth performance, antioxidant capacity, and immune function in weaned pigs.
Review
Neurosciences
Alfredo Llorca, Ruben Deogracias
Summary: This review describes the diversity of interneurons that make up local circuits in the neocortex and summarizes the mechanisms underlying their development and assembly into functional networks.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Hong Cheng, Yan Huang, Wei Chen, Jifei Che, Taidong Liu, Jing Na, Ruojin Wang, Yubo Fan
Summary: The combinational effect of cyclic strain and electrical stimulation was found to significantly promote the neural differentiation of rat bone marrow-derived mesenchymal stem cells, enhancing the expression of neural markers and upregulating neurotrophic factors and cAMP. In addition, co-stimulation further enhanced calcium influx and phosphorylation of ERK1/2 and AKT in neural differentiated BMSCs, suggesting a synergistic effect of the combination on stem cell neuronal differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
M. Angeles Varo, Juan Martin-Gomez, Julieta Merida, Maria P. Serratosa
Summary: The study found that different varieties of blueberries have significant differences in bioactive compounds and antioxidant activity. Millennia had the highest concentration of monomeric anthocyanins, while Windsor had the highest total tannins concentration and best antioxidant activity values.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Plant Sciences
Mohammad Reza Fayezizadeh, Naser Alemzadeh Ansari, Mohammad Mahmoudi Sourestani, Mirza Hasanuzzaman
Summary: This study investigated the biochemical compounds, antioxidant capacity, leaf color profile, and yield of 21 cultivars and genotypes of basil microgreen. Results showed that the Persian Ablagh genotype had the highest antioxidant potential composite index (APCI) and that the basil genotypes were classified into four clusters based on their phytochemical components. The principal components analysis revealed diversity among basil genotypes, with the origin of basil seeds playing an important role in antioxidant synthesis.
Article
Biochemistry & Molecular Biology
Eder Ramirez, Nery Jara, Luciano Ferrada, Katterine Salazar, Fernando Martinez, Maria Jose Oviedo, Joanna Tereszczuk, Sebastian Ramirez-Carbonell, Arabel Vollmann-Zwerenz, Peter Hau, Francisco Nualart
Summary: The study shows that vitamin C plays a crucial role in the development and progression of glioblastoma by promoting collagen synthesis and impacting tumor growth and invasion. Vitamin C deficiency leads to collagen retention, reduced blood vessel invasion, and altered blood vessel structure formation.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Endocrinology & Metabolism
Beatriz Morte, Pilar Gil-Ibanez, Heike Heuer, Juan Bernal
Summary: The study suggests that the neurological impairment in AHDS cannot be fully explained by TH deprivation alone.
Article
Neurosciences
Luiza Filipis, Marco Canepari
Summary: **This study presents the first optical measurement of Na+ currents in the axon initial segment (AIS) of pyramidal neurons in the somatosensory cortex, demonstrating the ability to track the kinetics of Na+ current during action potential generation more effectively. The results also show a correlation between the kinetics of Na+ current at different distances from the soma and the somatic action potential. Additionally, comparison with computer simulations of NEURON models revealed the potential of this approach in estimating the native behavior of Na+ channels accurately.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Elena Puris, Seppo Auriola, Sabrina Petralla, Robin Hartman, Mikko Gynther, Elizabeth C. M. de Lange, Gert Fricker
Summary: There is evidence that membrane transporters expressed at the blood-brain barrier and brain parenchymal cells play a role in Alzheimer's disease development. This study examined changes in transporter protein expression in the brain of TgF344AD rats compared to wild-type animals and found significant alterations. These findings provide insight into the molecular mechanisms of AD and the use of the TgF344AD rat model in drug development research.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Veedamali S. Subramanian, Trevor Teafatiller, Hamid Moradi, Jonathan S. Marchant
Summary: Intestinal absorption of vitamin C in humans is mediated by specific transporters, with decreased expression in patients with inflammatory bowel disease. In this study, histone deacetylase inhibitors were found to significantly decrease the expression and function of hSVCT1 in intestinal epithelial cells, partly mediated through transcription factor regulation and chromatin modification. Epigenetic regulation of SVCT1 expression in intestinal epithelia was demonstrated through HDAC isoforms two and three, with potential implications for vitamin C homeostasis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Chemistry, Applied
Cristian Tapia, Barbara Lopez, Allisson Astuya, Jose Becerra, Concetta Gugliandolo, Boris Parra, Miguel Martinez
Summary: This study evaluated the antiproliferative activity of bacterial pigments from Deinococcus sp. UDEC-P1 and Arthrobacter sp. UDEC-A13 against cancer cells. The results showed that these pigments have significant viability reduction effects on certain cancer cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Antonia Recabal, Paola Fernandez, Sergio Lopez, Maria J. Barahona, Patricio Ordenes, Alejandra Palma, Roberto Elizondo-Vega, Carlos Farkas, Amparo Uribe, Teresa Caprile, Juan C. Saez, Maria A. Garcia-Robles
Summary: In the adult hypothalamus, tanycytes play a role as neuronal precursors that can proliferate and differentiate into mature neurons under nutritional cues. FGF2 can induce tanycyte proliferation by opening Cx43 HCs and triggering purinergic signaling.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Magdiel Salgado, Maria a. Garcia-Robles, Juan C. Saez
Summary: Tanycytes are hypothalamic cells that play a crucial role in regulating neuroendocrine axes and energy homeostasis. Purinergic signaling is involved in their mechanism of action, influencing satiety-controlling hypothalamic neurons' activity. Tanycytes act as nutrient sensors in the hypothalamus, with connexin hemichannels being particularly relevant in this process.
PURINERGIC SIGNALLING
(2021)
Article
Multidisciplinary Sciences
P. Ordenes, P. S. Villar, E. Tarifeno-Saldivia, M. Salgado, R. Elizondo-Vega, Ricardo C. Araneda, Maria A. Garcia-Robles
Summary: The study investigated the impact of lactate receptor HCAR1 on POMC neurons, revealing that lactate can modulate neuronal excitability through both intracellular and intercellular actions, with HCAR1 mainly located in astrocytes rather than POMC neurons.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Magdiel Salgado, Roberto Elizondo-Vega, Pablo S. Villar, Macarena Konar, Scarlet Gallegos, Estefania Tarifeno-Saldivia, Patricia Luz-Crawford, Luis G. Aguayo, Ricardo C. Araneda, Elena Uribe, Maria Angeles Garcia-Robles
Summary: This study investigates the role of glucokinase regulatory protein (GKRP) in metabolic regulation and feeding behavior. The results suggest that GKRP can modulate tanycyte-neuron metabolic communication to regulate feeding behavior, and it may serve as a therapeutic target for enhancing satiety in patients with obesity.
Article
Neurosciences
Camila Gherardelli, Pedro Cisternas, Roberto F. Vera-Salazar, Carolina Mendez-Orellana, Nibaldo C. Inestrosa
Summary: Alzheimer's disease is characterized by high etiological and clinical heterogeneity, with sex differences influencing glucose metabolism and age-dependent decline in metabolic responses, cognitive functions, and brain energy homeostasis observed. Andrographolide shows promise as a potential drug for personalized medicine in AD treatment.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Camila Gherardelli, Pedro Cisternas, Nibaldo C. Inestrosa
Summary: Impaired cerebral glucose metabolism is an early event in the pathogenesis of Alzheimer's disease. Lithium has been shown to stimulate glucose uptake and metabolism, potentially acting as a therapeutic agent in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Karina Oyarce, Maria Yamila Cepeda, Raul Lagos, Camila Garrido, Ana Maria Vega-Letter, Maria Garcia-Robles, Patricia Luz-Crawford, Roberto Elizondo-Vega
Summary: This article reviews the effects of exosomes derived from glial cells on neurons and other glia in the context of neurodegeneration and neuroinflammation, as well as how specific stress stimuli and pathological conditions can alter exosome secretion levels and properties.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Antonia Recabal, Sergio Lopez, Magdiel Salgado, Alejandra Palma, Ana M. Obregon, Roberto Elizondo-Vega, Juan C. Saez, Maria A. Garcia-Robles
Summary: Radial glia-like cells in the hypothalamus and dorsal vagal complex are neural precursors that can detect blood-borne nutrients and hormones and increase their proliferation in response to a high-fat diet. This study found that a short-term high sucrose diet can also increase the proliferation of these precursors, while fructose alone does not have the same effect as glucose.
Article
Environmental Sciences
Allisson Astuya-Villalon, Barbara Lopez, Veronica Avello, Alejandra Rivera, Ambbar Aballay-Gonzalez, Viviana Ulloa, Alejandra Aguilera-Belmonte, Juan Jose Gallardo-Rodriguez
Summary: Ichthyotoxic algal blooms cause significant economic losses worldwide. This research investigates the allelopathic effects of two bloom-forming species, Heterosigma akashiwo and Alexandrium catenella, and their relationship with ichthyotoxicity. The results show that the allelopathic inhibitory effect between these species is enhanced when they are in direct contact. Additionally, A. catenella is capable of reducing the cell concentration of H. akashiwo and Rhodomonas salina. These findings suggest that allelopathy, regulated by the presence of other microalgae, may play a role in ichthyotoxicity.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
M. J. Barahona, F. Langlet, G. Labouebe, S. Croizier, A. Picard, Bernard Thorens, Maria A. Garcia-Robles
Summary: This study found that a GLUT2-dependent glucose-sensing mechanism in GFAP-positive tanycytes is crucial for the normal regulation of feeding behavior. Inactivation of GLUT2 in GFAP-positive tanycytes led to delayed meal initiation and decreased food intake after fasting. The loss of glucose sensing also resulted in an increase in c-Fos-positive cells in the ventromedial nucleus and deregulation of Pomc expression in the fasting-to-refeeding transition.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Paulina Villaseca, Pedro Cisternas, Nibaldo C. Inestrosa
Summary: Late onset Alzheimer's disease (AD) exhibits gender differences in onset and progression, with higher prevalence and earlier age in women. The pathophysiology of menopause is associated with the development of AD, affecting endocrine and glucose metabolism. This review discusses the role of estrogen deficiency in AD development, including the formation of senile plaques and neurofibrillary tangles, glucose brain metabolism, Wnt signaling, and glucose transport.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biology
Catalina Novoa, Paulina Salazar, Pedro Cisternas, Camila Gherardelli, Roberto Vera-Salazar, Juan M. Zolezzi, Nibaldo C. Inestrosa
Summary: Alzheimer's disease is characterized by accumulation of A beta and Tau protein aggregates, leading to neuroinflammation through activation of astrocytes and microglia. Inflammatory response can have dual functions, either promoting A beta degradation and clearance or contributing to neurodegeneration. Inflammatory markers and anti-inflammatory drugs show potential for AD treatment, while diseases related to inflammation are considered risk factors for AD development.
BIOLOGICAL RESEARCH
(2022)
Article
Psychiatry
Ana M. Obregon, Karina Oyarce, Maria A. Garcia-Robles, Macarena Valladares, Paulina Pettinelli, Gary S. Goldfield
Summary: The study found an association between the DRD2 polymorphism (rs1800497) and eating behavior, food reinforcement, and food addiction in Chilean adults, with obese women carrying the A1 allele at higher risk.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2022)
Article
Medicine, Research & Experimental
Rafael Contreras-Lopez, Roberto Elizondo-Vega, Noymar Luque-Campos, Maria Jose Torres, Carolina Pradenas, Gautier Tejedor, Maria Jose Paredes-Martinez, Ana Maria Vega-Letter, Mauricio Campos-Mora, Yandi Rigual-Gonzalez, Karina Oyarce, Magdiel Salgado, Christian Jorgensen, Maroun Khoury, Maria de los Angeles Garcia-Robles, Claudia Altamirano, Farida Djouad, Patricia Luz-Crawford
Summary: The study showed that metabolic reprogramming of MSC using oligomycin and other pro-inflammatory factors could significantly enhance their immunosuppressive properties, thereby improving their therapeutic efficacy in inflammatory diseases. Furthermore, the glycolytic reprogramming of MSC also partly depended on the activation of the AMPK signaling pathway.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)