Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
Published 2022 View Full Article
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Title
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
Authors
Keywords
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Journal
Molecular Neurodegeneration
Volume 17, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-09-02
DOI
10.1186/s13024-022-00562-8
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Note: Only part of the references are listed.- Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
- (2022) Chao Wang et al. Nature Communications
- TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis
- (2021) Jinchao Hou et al. JOURNAL OF CLINICAL INVESTIGATION
- Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
- (2021) Seung-Hye Lee et al. NEURON
- Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state
- (2021) Anastasie Maté de Gérando et al. BRAIN
- Cellular and pathological heterogeneity of primary tauopathies
- (2021) Dah-eun Chloe Chung et al. Molecular Neurodegeneration
- Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading
- (2021) Yin Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
- (2021) Argyro Thalia Delizannis et al. Acta Neuropathologica Communications
- Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
- (2020) Jacob W. Vogel et al. Nature Communications
- Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis
- (2020) Jessica Stupack et al. JOURNAL OF NEUROSCIENCE
- Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
- (2020) Tiantian Guo et al. Molecular Neurodegeneration
- P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice
- (2020) Zhi Ruan et al. Molecular Neurodegeneration
- TREM2 function impedes tau seeding in neuritic plaques
- (2019) Cheryl E. G. Leyns et al. NATURE NEUROSCIENCE
- NLRP3 inflammasome activation drives tau pathology
- (2019) Christina Ising et al. NATURE
- Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)
- (2018) Li Zhong et al. Molecular Neurodegeneration
- TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
- (2018) Yingjun Zhao et al. NEURON
- Unconventional Secretion Mediates the Trans-cellular Spreading of Tau
- (2018) Taxiarchis Katsinelos et al. Cell Reports
- The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease
- (2018) Sarah C. Hopp et al. Journal of Neuroinflammation
- Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
- (2018) Faten A. Sayed et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Partial reduction of microglia does not affect tau pathology in aged mice
- (2018) Rachel E. Bennett et al. Journal of Neuroinflammation
- Secretion of Tau via an Unconventional Non-vesicular Mechanism
- (2018) Maria Merezhko et al. Cell Reports
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration
- (2017) Timothy Y. Huang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
- (2017) Shane M. Bemiller et al. Molecular Neurodegeneration
- Tau Pathology Distribution in Alzheimer's disease Corresponds Differentially to Cognition-Relevant Functional Brain Networks
- (2017) Oskar Hansson et al. Frontiers in Neuroscience
- ExoCarta: A Web-Based Compendium of Exosomal Cargo
- (2016) Shivakumar Keerthikumar et al. JOURNAL OF MOLECULAR BIOLOGY
- LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
- (2016) Longyu Yang et al. Journal of Neuroinflammation
- Neuronal activity enhances tau propagation and tau pathology in vivo
- (2016) Jessica W Wu et al. NATURE NEUROSCIENCE
- PET Imaging of Tau Deposition in the Aging Human Brain
- (2016) Michael Schöll et al. NEURON
- TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
- (2016) Felix L. Yeh et al. NEURON
- Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
- (2016) Meryem Tardivel et al. Acta Neuropathologica Communications
- Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
- (2015) Nicole Maphis et al. BRAIN
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Depletion of microglia and inhibition of exosome synthesis halt tau propagation
- (2015) Hirohide Asai et al. NATURE NEUROSCIENCE
- Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice
- (2015) Teng Jiang et al. NEUROBIOLOGY OF AGING
- Engram cells retain memory under retrograde amnesia
- (2015) T. J. Ryan et al. SCIENCE
- Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory
- (2015) Noriaki Ohkawa et al. Cell Reports
- MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments
- (2014) Meena Choi et al. BIOINFORMATICS
- Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles
- (2013) P Joshi et al. CELL DEATH AND DIFFERENTIATION
- A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's Disease
- (2013) Aida Attar et al. PLoS One
- Constitutive secretion of tau protein by an unconventional mechanism
- (2012) Xiyun Chai et al. NEUROBIOLOGY OF DISEASE
- Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
- (2012) Alix de Calignon et al. NEURON
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Trans-Synaptic Spread of Tau Pathology In Vivo
- (2012) Li Liu et al. PLoS One
- Dynamics of Retrieval Strategies for Remote Memories
- (2011) Inbal Goshen et al. CELL
- Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease
- (2011) Sudad Saman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
- (2011) Adam C Naj et al. NATURE GENETICS
- Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
- (2011) Paul Hollingworth et al. NATURE GENETICS
- ExoCarta 2012: database of exosomal proteins, RNA and lipids
- (2011) S. Mathivanan et al. NUCLEIC ACIDS RESEARCH
- CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models
- (2010) Sungho Lee et al. AMERICAN JOURNAL OF PATHOLOGY
- Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling
- (2010) Arthit Chairoungdua et al. JOURNAL OF CELL BIOLOGY
- Regulation of Tau Pathology by the Microglial Fractalkine Receptor
- (2010) Kiran Bhaskar et al. NEURON
- Propagation of Tau Misfolding from the Outside to the Inside of a Cell
- (2009) Bess Frost et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transmission and spreading of tauopathy in transgenic mouse brain
- (2009) Florence Clavaguera et al. NATURE CELL BIOLOGY
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- ExoCarta: A compendium of exosomal proteins and RNA
- (2009) Suresh Mathivanan et al. PROTEOMICS
- Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE
- (2008) Lars Bertram et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
- (2008) Da Wei Huang et al. NUCLEIC ACIDS RESEARCH
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