Role of STAT3 in the initiation, progression, proliferation and metastasis of breast cancer and strategies to deliver JAK and STAT3 inhibitors

Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway

(2022) S. Preethi et al.   MOLECULAR BIOLOGY REPORTS

Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment

(2022) Hitesh Kumar et al.   Frontiers in Pharmacology

HnRNPA2B1 promotes the proliferation of breast cancer MCF‐7 cells via the STAT3 pathway

(2021) Li‐Bin Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Opioids drive breast cancer metastasis through the δ-opioid receptor and oncogenic STAT3

(2021) Sabrina Tripolt et al.   NEOPLASIA

The Anticancer Effects of Flavonoids through miRNAs Modulations in Triple-Negative Breast Cancer

(2021) Getinet M. Adinew et al.   Nutrients

STAT3 pathway as a molecular target for resveratrol in breast cancer treatment

(2021) Zeynab Kohandel et al.   Cancer Cell International

The Cytotoxicity Effect of Curcumin Loaded Folic Acid Conjugated-Nanoparticles on Breast Cancer Cells and Its Association with Inhibition of STAT3 Phosphorylation

(2021) Elnaz Faghfuri et al.   JOURNAL OF CLUSTER SCIENCE

SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3

(2021) Yong Teng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Effect of MiR-210 on the Chemosensitivity of Breast Cancer by Regulating JAK-STAT Signaling Pathway

(2021) Zeyu Xing et al.   Biomed Research International

Notch Signalling in Breast Development and Cancer

(2021) Abigail Edwards et al.   Frontiers in Cell and Developmental Biology

Role of STAT3 signaling pathway in breast cancer

(2020) Jia-hui Ma et al.   Cell Communication and Signaling

The role of JAK/STAT signaling pathway and its inhibitors in diseases

(2020) Ping Xin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Long noncoding RNA BHLHE40‐AS1 promotes early breast cancer progression through modulating IL‐6/STAT3 signaling

(2020) Rebecca S. DeVaux et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Janus kinase inhibitors: A therapeutic strategy for cancer and autoimmune diseases

(2020) Arezoo Hosseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pracinostat (SB939), a histone deacetylase inhibitor, suppresses breast cancer metastasis and growth by inactivating the IL-6/STAT3 signalling pathways

(2020) Jing Chen et al.   LIFE SCIENCES

Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation

(2020) Di Chen et al.   MOLECULES

EGFR Promotes the Development of Triple Negative Breast Cancer Through JAK/STAT3 Signaling

(2020) Xiang Song et al.   Cancer Management and Research

LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer

(2020) Li Pan et al.   BREAST CANCER RESEARCH AND TREATMENT

Codelivery of STAT3 siRNA and BV6 by carboxymethyl dextran trimethyl chitosan nanoparticles suppresses cancer cell progression

(2020) Afshin Nikkhoo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dual drug delivery of curcumin and niclosamide using PLGA nanoparticles for improved therapeutic effect on breast cancer cells

(2020) Prabhuraj R.S. et al.   JOURNAL OF POLYMER RESEARCH

Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR

(2020) Miguel A. Ortega et al.   Journal of Oncology

Nobiletin as a Molecule for Formulation Development: An Overview of Advanced Formulation and Nanotechnology-Based Strategies of Nobiletin

(2020) Siddharth S. Kesharwani et al.   AAPS PHARMSCITECH

IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

(2020) Rasmus Siersbæk et al.   CANCER CELL

Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways

(2020) Zhao Qu et al.   OncoTargets and Therapy

JAK-STAT Signalling Pathway in Cancer

(2020) Andrew J. Brooks et al.   Cancers

Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells

(2020) Gorrepotu Dani Susmitha et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

(2020) Xiufang Xu et al.   Molecular Cancer

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

(2020) Jinfeng Shi et al.   Frontiers in Pharmacology

Eucannabinolide, a novel sesquiterpene lactone, suppresses the growth, metastasis and BCSCS-like traits of TNBC via inactivation of STAT3

(2020) Zhihui Zhu et al.   NEOPLASIA

Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression

(2020) Su-Jung Kim et al.   CANCER LETTERS

Design and evaluation of cabazitaxel loaded NLCs against breast cancer cell lines

(2020) Pallavi Chand et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Cucurbitacin mediated regulation of deregulated oncogenic signaling cascades and non-coding RNAs in different cancers: Spotlight on JAK/STAT, Wnt/β-catenin, mTOR, TRAIL-mediated pathways

(2020) Xiukun Lin et al.   SEMINARS IN CANCER BIOLOGY

SP1 and STAT3 Functionally Synergize to Induce the RhoU Small GTPase and a Subclass of Non-canonical WNT Responsive Genes Correlating with Poor Prognosis in Breast Cancer

(2019) Emanuele Monteleone et al.   Cancers

Dihydrotanshinone-Induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROS/Stat3 Signaling Pathway

(2019) Su-Lim Kim et al.   Oxidative Medicine and Cellular Longevity

C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition

(2019) Tae-Min Cho et al.   CANCER LETTERS

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

(2019) Jiang-Jiang Qin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation

(2019) Xueqiang Gao et al.   Breast Cancer

Downregulation of DPF3 promotes the proliferation and motility of breast cancer cells through activating JAK2/STAT3 signaling

(2019) Wei-hao Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Piperlongumine Induces Apoptosis and Synergizes with Doxorubicin by Inhibiting the JAK2-STAT3 Pathway in Triple-Negative Breast Cancer

(2019) Di Chen et al.   MOLECULES

A Sesquiterpenoid from Farfarae Flos Induces Apoptosis of MDA-MB-231 Human Breast Cancer Cells through Inhibition of JAK–STAT3 Signaling

(2019) Hyeri Jang et al.   Biomolecules

Nanoparticles Targeting STATs in Cancer Therapy

(2019) Milad Ashrafizadeh et al.   Cells

Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3

(2019) Halima Alsamri et al.   Frontiers in Oncology

Targeting STAT3 in Cancer with Nucleotide Therapeutics

(2019) Yue-Ting K. Lau et al.   Cancers

Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo

(2019) Zhe Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3

(2019) Susana P. Egusquiaguirre et al.   NEOPLASIA

Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition

(2018) Eunhye Oh et al.   INTERNATIONAL JOURNAL OF CANCER

The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer

(2018) Katherine Hughes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inorganic kernel - Supported asymmetric hybrid vesicles for targeting delivery of STAT3-decoy oligonucleotides to overcome anti-HER2 therapeutic resistance of BT474R

(2018) Kai Shi et al.   JOURNAL OF CONTROLLED RELEASE

Hyaluronic acid modified daunorubicin plus honokiol cationic liposomes for the treatment of breast cancer along with the elimination vasculogenic mimicry channels

(2018) Rui-Jun Ju et al.   JOURNAL OF DRUG TARGETING

Histone deacetylase 6 regulates the immunosuppressive properties of cancer-associated fibroblasts in breast cancer through the STAT3–COX2-dependent pathway

(2018) Ang Li et al.   ONCOGENE

GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling

(2018) Puja Khanna et al.   Scientific Reports

The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells

(2018) Susana P. Egusquiaguirre et al.   NEOPLASIA

STAT3 in Breast Cancer Onset and Progression: A Matter of Time and Context

(2018) Ilenia Segatto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long noncoding RNA H19 competitively binds miR-93-5p to regulate STAT3 expression in breast cancer

(2018) Jia-Peng Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cyanidin-3-glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3/VEGF pathway

(2018) Xiao Ma et al.   PHYTOTHERAPY RESEARCH

The molecular details of cytokine signalling via the JAK/STAT pathway

(2018) Rhiannon Morris et al.   PROTEIN SCIENCE

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

(2018) Renxu Chang et al.   Nature Communications

Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β‐catenin, JAK‐STAT pathways, and microRNAs

(2018) Ulku Ozbey et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Methylseleninic Acid Suppresses Breast Cancer Growth via the JAK2/STAT3 Pathway

(2018) Changwei Qiu et al.   Reproductive Sciences

Overexpression of MicroRNA-9 inhibits proliferation of human breast cancer cells by targeting STAT3

(2018) Yan Zhang et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy

(2018) Wenda Zhang et al.   Cell Death & Disease

Ascochlorin Suppresses MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades

(2017) Hyun-Ji Cho et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A phase 1 study of the Janus kinase 2 ( JAK2 ) V617F inhibitor, gandotinib (LY2784544), in patients with primary myelofibrosis, polycythemia vera, and essential thrombocythemia

(2017) Srdan Verstovsek et al.   LEUKEMIA RESEARCH

Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition

(2017) Bernd Groner et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

STAT3 Inhibitory Activity of Structurally Simplified Withaferin A Analogues

(2017) Teruyuki Tahara et al.   ORGANIC LETTERS

Malignancy and Janus Kinase Inhibition

(2017) Padmapriya Sivaraman et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

JAK-STAT signaling in cancer: From cytokines to non-coding genome

(2016) Jan Pencik et al.   CYTOKINE

Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein

(2016) Shanshan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of STAT3 Phosphorylation in Ethanol-Mediated Proliferation of Breast Cancer Cells

(2016) Poornima devi Narayanan et al.   Journal of Breast Cancer

Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis

(2016) Fang Liu et al.   ONCOLOGY REPORTS

RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway

(2015) Fei Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo

(2015) P. Yue et al.   CANCER RESEARCH

STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis

(2015) Laura M. Jones et al.   CANCER RESEARCH

Stat3-siRNA inhibits the growth of gastric cancerin vitroandin vivo

(2015) Ying Sun et al.   CELL BIOCHEMISTRY AND FUNCTION

Constitutive activation of STAT3 in breast cancer cells: A review

(2015) Kasturi Banerjee et al.   INTERNATIONAL JOURNAL OF CANCER

Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells

(2015) Jin Mo Ku et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

(2015) David Hong et al.   Science Translational Medicine

Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma

(2015) Jiao Ma et al.   Oncotarget

Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells

(2015) Hyunsook An et al.   PLoS One

Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling

(2015) Ilenia Segatto et al.   Oncotarget

MRTF-A and STAT3 synergistically promote breast cancer cell migration

(2014) Xing-Hua Liao et al.   CELLULAR SIGNALLING

Signaling pathways in breast cancer: Therapeutic targeting of the microenvironment

(2014) Armel Herve Nwabo Kamdje et al.   CELLULAR SIGNALLING

Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3

(2014) Mon-Yuan Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells

(2014) RENG-YUN LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Assessment of drug delivery and anticancer potentials of nanoparticles-loaded siRNA targeting STAT3 in lung cancer, in vitro and in vivo

(2014) Jayeeta Das et al.   TOXICOLOGY LETTERS

The Role of STAT3 in Non-Small Cell Lung Cancer

(2014) Daijiro Harada et al.   Cancers

MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer

(2013) S. B. Pakala et al.   CANCER RESEARCH

Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells

(2013) Seog-Young Kim et al.   CELLULAR SIGNALLING

Epithelial to Mesenchymal Transition Promotes Breast Cancer Progression via a Fibronectin-dependent STAT3 Signaling Pathway

(2013) Nikolas Balanis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3, a Poor Survival Predicator, Is Associated with Lymph Node Metastasis from Breast Cancer

(2013) Yujuan Chen et al.   Journal of Breast Cancer

Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer

(2013) Sarah R. Walker et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

STAT signaling in different breast cancer sub-types

(2013) Priscilla A. Furth   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Stat3 paradox: A killer and an oncogene

(2013) Henrike K. Resemann et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

(2012) Xin-Sheng Deng et al.   CELL CYCLE

Suppression of tumor invasion and migration in breast cancer cells following delivery of siRNA against Stat3 with the antimicrobial peptide PR39

(2012) WENXIA TIAN et al.   ONCOLOGY REPORTS

Effects of 5-fluorouracil and gemcitabine on a breast cancer cell line (MCF-7) via the JAK/STAT pathway

(2011) Elgin Turkoz Uluer et al.   ACTA HISTOCHEMICA

Oral administration of penta-O-galloyl- -D-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition

(2011) H.-J. Lee et al.   CARCINOGENESIS

Plasmid-based STAT3-siRNA efficiently inhibits breast tumor growth and metastasis in mice

(2011) L. DAI et al.   NEOPLASMA

Lestaurtinib Inhibition of the JAK/STAT Signaling Pathway in Hodgkin Lymphoma Inhibits Proliferation and Induces Apoptosis

(2011) Tania Diaz et al.   PLoS One

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

(2010) A. Quintas-Cardama et al.   BLOOD

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent

(2010) Peramaiyan Rajendran et al.   BRITISH JOURNAL OF PHARMACOLOGY

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression

(2009) J. J. Ranger et al.   CANCER RESEARCH

Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells

(2009) R. Behera et al.   CARCINOGENESIS

Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells

(2008) Esha Madan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS