Review
Immunology
Iara M. M. Backes, David A. A. Leib, Margaret E. E. Ackerman
Summary: The fetal/neonatal period is a critical stage for interventions and also a vulnerable period for viral infections. Maternal transfer of antibodies can reduce the risk of neonatal herpes simplex virus (nHSV) infections. Exploring the combination of antibody-based interventions and antiviral therapy is important for reducing infant mortality and long-term morbidity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle
Summary: This study reveals that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in the rash-involved skin after recovery from zoster, indicating their importance in controlling skin infections.
NATURE COMMUNICATIONS
(2022)
Review
Microbiology
Sajal Deea Shukla, Tibor Valyi-Nagy
Summary: HSV-1 is a human virus that causes lifelong infections and can lead to various diseases, including blindness and central nervous system diseases. Host molecules play important roles in the infection process, including immune response, autophagy, and inflammation. Understanding the interaction between the virus and host molecules is essential for developing effective treatments.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giorgia Napoletani, Virginia Protto, Maria Elena Marcocci, Lucia Nencioni, Anna Teresa Palamara, Giovanna De Chiara
Summary: This study investigated the impact of recurrent HSV-1 infection on neuronal aging, revealing a significant increase in H4K16ac, Sin3, and HDAC1 levels, which are related to aging markers. There was a significant decrease in H3K56ac specifically linked to viral reactivation, and a complex modulation of HIRA expression and localization in HSV-1 infected mouse brains, suggesting a specific role of this protein in viral latency and reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Samuel Montenegro Pereira, Rian Vilar Lima, Maria Carolina Rocha Muniz, Marcus Breno Farias Araujo, Luiz de Moraes Ferreira Jr, Juliana Tiburtino de Queiroz Sales Martins, Claudia Faustino Coelho Luz, David Antonio Camelo Cid, Daniel da Rocha Lucena
Summary: Neonatal herpes simplex virus (HSV) infection is a rare disease that commonly presents with mucocutaneous lesions and neurological involvement. This case report describes a rare congenital herpes case with ophthalmologic manifestations and multisystemic involvement.
Article
Chemistry, Medicinal
Kai Jiang, Jing Feng, Xia Qi, Lili Ran, Lixin Xie
Summary: This study validated the inhibitory effect of oridonin on herpes simplex virus type 1 and demonstrated its potential in alleviating herpes simplex keratitis infection in mice.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Immunology
Christine Johnston
Summary: This article discusses the management of genital herpes infection and provides recommendations based on a systematic literature review, serving as a basis for updating the treatment guidelines.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Immunology
Shiza Malik, Ranjit Sah, Omar Ahsan, Khalid Muhammad, Yasir Waheed
Summary: Research on herpes simplex virus (HSV) indicates that current antiviral therapies can alleviate symptoms and control viral transmission, but they cannot eradicate HSV infection and latency. The complex nature of the virus requires continued efforts to develop new treatment methods to control its spread and mutations.
Article
Medicine, General & Internal
Fadi Shahoud, Mobeen H. Rathore, Chetan C. Shah, Rana Alissa
Summary: This case series explores the different manifestations of central nervous system (CNS) involvement in neonatal herpes simplex virus (HSV) infection and highlights the challenges in diagnosis and treatment. Neonatal HSV infection is a rare but serious condition with potential neurological consequences. The article presents three cases, each with distinct clinical features and outcomes. While early diagnosis and treatment are important, some cases may still have a poor prognosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Sita Awasthi, James J. Knox, Angela Desmond, Mohamad-Gabriel Alameh, Brian T. Gaudette, John M. Lubinski, Alexis Naughton, Lauren M. Hook, Kevin P. Egan, Ying K. Tam, Norbert Pardi, David Allman, Eline T. Luning Prak, Michael P. Cancro, Drew Weissman, Gary H. Cohen, Harvey M. Friedman
Summary: Nucleoside-modified mRNA vaccines show more durable protection in animal models compared to protein vaccines, with higher neutralizing antibody titers and robust B cell immune memory. The correlation between high neutralizing titers and B cell immune memory likely explains the more lasting protection provided by the mRNA vaccine.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Virology
Chun Kiat Lee, Sau Yoke Ng, Chean Nee Chai, Yu Feng Lim, Tiffany Jingyan Hu, Ogestelli Fabia Lee, Gabriel Yan
Summary: This study reports a case where unbiased metagenomic next-generation sequencing (mNGS) was successfully used as a rapid method to confirm dual genital herpes co-infection. mNGS identified specific sequences for HSV-1 or HSV-2, ruling out potential mis-genotyping by the Luminex ARIES assay. The findings suggest that mNGS can serve as a rapid and reliable alternative confirmatory method for dual genital herpes infections.
Article
Infectious Diseases
Anja Naas, Peng Li, Clas Ahlm, Elisabeth Aurelius, Josef D. Jarhult, Silvia Schliamser, Marie Studahl, Wenzhong Xiao, Jonas Bergquist, Gabriel Westman
Summary: This study investigated the temporal changes of the CSF proteome in patients with herpes simplex encephalitis (HSE) and its association with factors such as anti-NMDAR serostatus, corticosteroid treatment, brain MRI, and neurocognitive performance. The results showed that the composition and activation pathways of CSF proteins vary at different stages of the disease. Additionally, it was found that several proteins were less abundant in patients with anti-NMDAR seropositivity compared to seronegativity.
INFECTIOUS DISEASES
(2023)
Article
Immunology
Meng-Shan Tsai, Shun-Hua Chen, Chih-Peng Chang, Yi-Ling Hsiao, Li-Chiu Wang
Summary: ILK reduces the accumulation of H3K9me3 on HSV-1 DNA by reducing SUV39H1 and TRIM28 binding, enhancing virus replication. ILK knockdown decreases TRIM28 phosphorylation, weakening its inhibition on lytic gene transcription. ILK inhibitor suppresses HSV-1 replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Infectious Diseases
Ying Zhang, Li-Si Zeng, Juan Wang, Wen-Qi Cai, Weiwen Cui, Tong-Jun Song, Xiao-Chun Peng, Zhaowu Ma, Ying Xiang, Shu-Zhong Cui, Hong-Wu Xin
Summary: Latent infection affects HSV reactivation, and deleting LAT reduces the latency and recurrence of the virus, providing new ideas for the future development of therapeutics and vaccines.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Oncology
Julie K. Allen, Guillermo N. Armaiz-Pena, Archana S. Nagaraja, Nouara C. Sadaoui, Tatiana Ortiz, Robert Dood, Merve Ozcan, Danielle M. Herder, Monika Haemmerle, Kshipra M. Gharpure, Rajesha Rupaimoole, Rebecca A. Previs, Sherry Y. Wu, Sunila Pradeep, Xiaoyun Xu, Hee Dong Han, Behrouz Zand, Heather J. Dalton, Morgan Taylor, Wei Hu, Justin Bottsford-Miller, Myrthala Moreno-Smith, Yu Kang, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Vasudha Sehgal, Erika L. Spaeth, Prahlad T. Ram, Stephen T. C. Wong, Frank C. Marini, Gabriel Lopez-Berestein, Steve W. Cole, Susan K. Lutgendorf, Mariella De Biasi, Anil K. Sood
Article
Oncology
Claudia B. Colon-Echevarria, Tatiana Ortiz, Lizette Maldonado, Melanie J. Hidalgo-Vargas, Jaileene Perez-Morales, Alexandra N. Aquino-Acevedo, Roberto Herrera-Noriega, Margarita Bonilla-Claudio, Eida M. Castro, Guillermo N. Armaiz-Pena