Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides

Liquefaction of Semen Generates and Later Degrades a Conserved Semenogelin Peptide That Enhances HIV Infection

(2014) N. R. Roan et al.   JOURNAL OF VIROLOGY

Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses

(2013) Maral Yolamanova et al.   Nature Nanotechnology

Polyanionic Candidate Microbicides Accelerate the Formation of Semen-Derived Amyloid Fibrils to Enhance HIV-1 Infection

(2013) Suiyi Tan et al.   PLoS One

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

(2013) W. C. Koff et al.   SCIENCE

Vaginal Gel Formulation Based on Theaflavin Derivatives As a Microbicide to Prevent HIV Sexual Transmission

(2012) Jie Yang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Inhibition of semen-derived enhancer of virus infection (SEVI) fibrillogenesis by zinc and copper

(2012) Sarah R. Sheftic et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Microbicides for the prevention of sexually transmitted HIV infection

(2012) Quarraisha Abdool Karim et al.   Expert Review of Anti-Infective Therapy

Microbicides: still a long road to success

(2012) Christophe Vanpouille et al.   TRENDS IN MICROBIOLOGY

Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)

(2011) Ian McGowan et al.   AIDS

Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women

(2011) Salim S Abdool Karim et al.   AIDS

Peptides Released by Physiological Cleavage of Semen Coagulum Proteins Form Amyloids that Enhance HIV Infection

(2011) Nadia R. Roan et al.   Cell Host & Microbe

Allosteric Model of Maraviroc Binding to CC Chemokine Receptor 5 (CCR5)

(2011) Javier Garcia-Perez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligovalent Amyloid-Binding Agents Reduce SEVI-Mediated Enhancement of HIV-1 Infection

(2011) Christina C. Capule et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Naturally Occurring Fragments from Two Distinct Regions of the Prostatic Acid Phosphatase Form Amyloidogenic Enhancers of HIV Infection

(2011) F. Arnold et al.   JOURNAL OF VIROLOGY

Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages

(2011) C. Ochsenbauer et al.   JOURNAL OF VIROLOGY

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

(2011) Alex Sigal et al.   NATURE

SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

(2011) Clare F. Price et al.   PLoS One

Female Genital Tract Secretions and Semen Impact the Development of Microbicides for the Prevention of HIV and Other Sexually Transmitted Infections

(2010) Betsy C. Herold et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Amyloid-binding Small Molecules Efficiently Block SEVI (Semen-derived Enhancer of Virus Infection)- and Semen-mediated Enhancement of HIV-1 Infection

(2010) Joanna S. Olsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection of Rhesus Macaques from Vaginal Infection by Vaginally Delivered Maraviroc, an Inhibitor of HIV‐1 Entry via the CCR5 Co‐Receptor

(2010) Ronald S. Veazey et al.   JOURNAL OF INFECTIOUS DISEASES

PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial

(2010) Sheena McCormack et al.   LANCET

Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI

(2010) Kyeong-Ae Kim et al.   Retrovirology

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1

(2009) Dana Huskens et al.   ANTIVIRAL RESEARCH

Maraviroc Concentrates in the Cervicovaginal Fluid and Vaginal Tissue of HIV-Negative Women

(2009) Julie B Dumond et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Aminoquinoline Surfen Inhibits the Action of SEVI (Semen-derived Enhancer of Viral Infection)

(2009) Nadia R. Roan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection

(2009) I. Hauber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Comprehensive Human Immunodeficiency Virus Type 1 Screening Algorithm for Discovery and Preclinical Testing of Topical Microbicides

(2008) C. Lackman-Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission

(2008) Lut Van Damme et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whither or Wither Microbicides?

(2008) R. M. Grant et al.   SCIENCE