A perinuclear calcium compartment regulates cardiac myocyte hypertrophy

Targeting mAKAPβ expression as a therapeutic approach for ischemic cardiomyopathy

(2022) Eliana C. Martinez et al.   GENE THERAPY

cAMP At Perinuclear mAKAPα Signalosomes Is Regulated By Local Ca2+ Signaling In Primary Hippocampal Neurons

(2021) Tomasz Boczek et al.   eNeuro

Calcium Release Channels: Structure and Function of IP3 Receptors and Ryanodine Receptors

(2021) Kellie A Woll et al.   PHYSIOLOGICAL REVIEWS

Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy

(2020) Xiaofeng Li et al.   CIRCULATION

Signalosome-Regulated SRF Phosphorylation Determining Myocyte Growth in Width versus Length as a Therapeutic Target for Heart Failure

(2020) Jinliang Li et al.   CIRCULATION

AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9

(2020) Silvia Vergarajauregui et al.   eLife

Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment

(2019) Tomasz Boczek et al.   JOURNAL OF NEUROSCIENCE

Calcium Signaling in Cardiomyocyte Function

(2019) Guillaume Gilbert et al.   Cold Spring Harbor Perspectives in Biology

mAKAPβ signalosomes – A nodal regulator of gene transcription associated with pathological cardiac remodeling

(2019) Kimberly Dodge-Kafka et al.   CELLULAR SIGNALLING

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle

(2019) Ian Holt et al.   Scientific Reports

Muscle A-kinase–anchoring protein-β–bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D

(2018) Jinliang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response

(2018) Duilio M. Potenza et al.   JOURNAL OF GENERAL PHYSIOLOGY

The structural basis of ryanodine receptor ion channel function

(2017) Gerhard Meissner   JOURNAL OF GENERAL PHYSIOLOGY

Calcineurin signaling in the heart: The importance of time and place

(2017) Valentina Parra et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structural Basis for Gating and Activation of RyR1

(2016) Amédée des Georges et al.   CELL

Regulation of sarcoplasmic reticulum Ca2+ release by serine-threonine phosphatases in the heart

(2016) Dmitry Terentyev et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

mAKAP—A Master Scaffold for Cardiac Remodeling

(2015) Catherine L. Passariello et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Nuclear Calcium in Cardiac Myocytes

(2015) Senka Ljubojevic et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The Scaffold Protein Muscle A-Kinase Anchoring Protein β Orchestrates Cardiac Myocyte Hypertrophic Signaling Required for the Development of Heart Failure

(2014) Michael D. Kritzer et al.   Circulation-Heart Failure

Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin

(2014) Sohum Mehta et al.   eLife

Parsing Good Versus Bad Signaling Pathways in the Heart

(2013) Jeffery D. Molkentin   CIRCULATION RESEARCH

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance

(2013) Wang Wang et al.   NATURE MEDICINE

Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and EC-coupling

(2012) Ernst Niggli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation

(2012) Maximilian A.X. Vargas et al.   CELLULAR SIGNALLING

Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes

(2012) Jinliang Li et al.   EXPERIMENTAL CELL RESEARCH

Nuclear inositol 1,4,5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy

(2012) Lilian A.M. Arantes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiomyocyte calcineurin signaling in subcellular domains: From the sarcolemma to the nucleus and beyond

(2011) Joerg Heineke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural evidence for perinuclear calcium microdomains in cardiac myocytes

(2010) Matias Escobar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

The mAKAPβ scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin

(2009) Jinliang Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endothelin-1-Stimulated InsP3-Induced Ca2+ Release Is a Nexus for Hypertrophic Signaling in Cardiac Myocytes

(2009) Daniel R. Higazi et al.   MOLECULAR CELL

Does Contractile Ca2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?

(2008) S. R. Houser et al.   Science Signaling