Iridium (III) complexes induce cervical carcinoma apoptosis via disturbing cellular redox homeostasis disorder and inhibiting PI3K/AKT/mTOR pathway

Iridium(III) complexes entrapped in liposomes trigger mitochondria-mediated apoptosis and GSDME-mediated pyroptosis

(2022) Huiwen Zhang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and anticancer activity in vitro and in vivo evaluation of iridium(III) complexes on mouse melanoma B16 cells

(2022) Yuhan Yuan et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Multifunctional heterometallic IrIII‐AuI probes as promising anticancer and antiangiogenic agents

(2021) Marta Redrado et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cervical cancer prevention and control in women living with human immunodeficiency virus

(2021) Philip E. Castle et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Evaluation of anticancer effects in vitro of new iridium(III) complexes targeting the mitochondria

(2021) Jing Hao et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Anticancer effect evaluation in vitro and in vivo of iridium(III) polypyridyl complexes targeting DNA and mitochondria

(2021) Huiwen Zhang et al.   BIOORGANIC CHEMISTRY

Iridium(III)-BBIP complexes induce apoptosis via PI3K/AKT/mTOR pathway and inhibit A549 lung tumor growth in vivo

(2021) Yi Zhou et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Increasing anticancer effect in vitro and vivo of liposome-encapsulated iridium(III) complexes on BEL-7402 cells

(2021) Yuanyuan Zhang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

DNA binding and evaluation of anticancer activity in vitro and in vivo of iridium(III) polypyridyl complexes

(2021) Yuanyuan Zhang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Thioredoxin System: a Promising Target for Cancer Drug Development

(2020) Norman Metanis et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cancer burden of major cancers in China: A need for sustainable actions

(2020) Maomao Cao et al.   Cancer Communications

A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy

(2020) Jinchao Shen et al.   BIOMATERIALS

p16/ki67 and E6/E7 mRNA accuracy and prognostic value in triaging HPV DNA-positive women

(2020) Paolo Giorgi Rossi et al.   JNCI-Journal of the National Cancer Institute

Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

(2020) Jian-Shu Lou et al.   PHYTOMEDICINE

Sulfur‐Coordinated Organoiridium(III) Complexes Exert Breast Anticancer Activity via Inhibition of Wnt/β‐Catenin Signaling

(2020) Qi Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An ER‐Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non‐Small‐Cell Lung Cancer

(2020) Lili Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

β-Phenylethylamine and various monomethylated and para-halogenated analogs. Acute toxicity studies in mice

(2019) Aron D. Mosnaim et al.   DRUG AND CHEMICAL TOXICOLOGY

Cervical cancer

(2019) Paul A Cohen et al.   LANCET

Systemic therapy in cervical cancer: 30 years in review

(2019) Michalis Liontos et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Mechanisms of resistance in estrogen receptor positive breast cancer: overcoming resistance to tamoxifen/aromatase inhibitors

(2018) Jamie N Mills et al.   CURRENT OPINION IN PHARMACOLOGY

PEGylated Multi-Stimuli Responsive Dendritic Prodrug-Based Nanoscale System for Enhanced Anticancer Activity

(2018) Zhenyu Duan et al.   ACS Applied Materials & Interfaces

Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities

(2018) Matthew R. Trendowski et al.   CLINICAL CANCER RESEARCH

Ruthenium(II) polypyridyl complexes: Synthesis, characterization and anticancer activity studies on BEL-7402 cells

(2017) Dan Wan et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240)

(2017) Krishnansu S Tewari et al.   LANCET

Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity

(2016) Chengyong He et al.   BIOMATERIALS

3D tumor spheroids: an overview on the tools and techniques used for their analysis

(2016) Elisabete C. Costa et al.   BIOTECHNOLOGY ADVANCES

Synthesis, characterization and anticancer effect of the ruthenium (II) polypyridyl complexes on HepG2 cells

(2016) Dan Wan et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Molecular mechanisms of cisplatin resistance in cervical cancer

(2016) Xueqiong Zhu et al.   Drug Design Development and Therapy

Mitochondrial Redox Signaling and Tumor Progression

(2016) Yuxin Chen et al.   Cancers

Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents

(2015) Yi Li et al.   BIOMATERIALS

Reactive Oxygen Species in Cancer: A Dance with the Devil

(2015) Paul T. Schumacker   CANCER CELL

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Cyclometalated iridium(iii) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents

(2015) Liang He et al.   Chemical Science

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

Organoiridium Complexes: Anticancer Agents and Catalysts

(2014) Zhe Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Evidence-Based Therapy for Recurrent Cervical Cancer

(2014) Bradley J. Monk et al.   JOURNAL OF CLINICAL ONCOLOGY

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors

(2013) Lívia B. Salum et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Induction of Apoptosis, G0/G1 Phase Arrest and Microtubule Disassembly in K562 Leukemia Cells by Mere15, a Novel Polypeptide from Meretrix meretrix Linnaeus

(2012) Ming Liu et al.   Marine Drugs

Quantifying colocalization by correlation: The Pearson correlation coefficient is superior to the Mander's overlap coefficient

(2010) Jeremy Adler et al.   CYTOMETRY PART A

PI-3-K and AKT: Onto the mitochondria☆

(2009) Bangyan L. Stiles   ADVANCED DRUG DELIVERY REVIEWS

Phase II Trial of Bevacizumab in the Treatment of Persistent or Recurrent Squamous Cell Carcinoma of the Cervix: A Gynecologic Oncology Group Study

(2009) Bradley J. Monk et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Induction of apoptosis accompanying with G1 phase arrest and microtubule disassembly in human hepatoma cells by jaspolide B, a new isomalabaricane-type triterpene

(2008) Shao-Yin Wei et al.   CANCER LETTERS

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE