Cyclometalated iridium(iii) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents

Intracellular Modulation of Excited-State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells

(2015) Safacan Kolemen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents

(2015) Yi Li et al.   BIOMATERIALS

A Luminescent Poly(amidoamine)–Iridium Complex as a New Singlet-Oxygen Sensitizer for Photodynamic Therapy

(2015) Daniela Maggioni et al.   INORGANIC CHEMISTRY

Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe

(2015) Ka-Ho Leung et al.   Chemical Science

Organoiridium Complexes: Anticancer Agents and Catalysts

(2014) Zhe Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Theranostic Iridium(III) Complexes as One- and Two-Photon Phosphorescent Trackers to Monitor Autophagic Lysosomes

(2014) Liang He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Specific Light-Up Bioprobe with Aggregation-Induced Emission and Activatable Photoactivity for the Targeted and Image-Guided Photodynamic Ablation of Cancer Cells

(2014) Youyong Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts

(2014) Zhe Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclometalated iridium(iii)–β-carboline complexes as potent autophagy-inducing agents

(2014) Liang He et al.   CHEMICAL COMMUNICATIONS

Cyclometalated Ir(iii) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy

(2014) Rui-Rong Ye et al.   CHEMICAL COMMUNICATIONS

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(ii) probe for in vivo imaging of live neurons

(2014) Yu-Man Ho et al.   CHEMICAL COMMUNICATIONS

Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents

(2014) Zahra Almodares et al.   INORGANIC CHEMISTRY

Histidine–Iridium(III) Coordination-Based Peptide Luminogenic Cyclization and Cyclo-RGD Peptides for Cancer-Cell Targeting

(2014) Xiaochuan Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors

(2014) Daishun Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of talaporfin sodium-mediated photodynamic therapy on cell death modalities in human glioblastoma T98G cells

(2014) Yuichi Miki et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Organelle-specific initiation of cell death

(2014) Lorenzo Galluzzi et al.   NATURE CELL BIOLOGY

Two in One: Luminescence Imaging and 730 nm Continuous Wave Laser Driven Photodynamic Therapy of Iridium Complexes

(2014) Fengfeng Xue et al.   ORGANOMETALLICS

Lysosome: the cell's ‘suicidal bag’ as a promising cancer target

(2014) Melina-Theoni Gyparaki et al.   TRENDS IN MOLECULAR MEDICINE

Bioactive Luminescent Transition-Metal Complexes for Biomedical Applications

(2013) Dik-Lung Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mitochondria-targeting cyclometalated iridium(III)–PEG complexes with tunable photodynamic activity

(2013) Steve Po-Yam Li et al.   BIOMATERIALS

Ruthenium-Arene-β-Carboline Complexes as Potent Inhibitors of Cyclin-Dependent Kinase 1: Synthesis, Characterization and Anticancer Mechanism Studies

(2013) Liang He et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cyclometalated Iridium(III) Complexes for Phosphorescence Sensing of Biological Metal Ions

(2013) Youngmin You et al.   INORGANIC CHEMISTRY

Phosphorescent Cellular Probes and Uptake Indicators Derived from Cyclometalated Iridium(III) Bipyridine Complexes Appended with a Glucose or Galactose Entity

(2013) Wendell Ho-Tin Law et al.   INORGANIC CHEMISTRY

Membrane Localized Iridium(III) Complex Induces Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptosis in Human Cancer Cells

(2013) Rui Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Control Over Photoinduced Electron Transfer in Phosphorescence Zinc Sensors

(2013) Hana Woo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzimidazole-Based Ratiometric Two-Photon Fluorescent Probes for Acidic pH in Live Cells and Tissues

(2013) Hyung Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Specific and pH-Activatable Rubyrin-Loaded Nanoparticles for Highly Selective Near-Infrared Photodynamic Therapy against Cancer

(2013) Jiangwei Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Killing from the inside

(2013) Paul Saftig et al.   NATURE

Near-Infrared-Emitting Iridium(III) Complexes as Phosphorescent Dyes for Live Cell Imaging

(2013) Guoliang Zhang et al.   ORGANOMETALLICS

Singlet Oxygen Generation by Cyclometalated Complexes and Applications

(2013) David Ashen-Garry et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

A dinuclear iridium(iii) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells

(2013) Guanying Li et al.   Chemical Science

Ratiometric Molecular Sensor for Monitoring Oxygen Levels in Living Cells

(2012) Toshitada Yoshihara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-light harvesting iridium complexes as singlet oxygen sensitizers for photooxidation of 1,5-dihydroxynaphthalene

(2012) Jifu Sun et al.   CHEMICAL COMMUNICATIONS

A pH-responsive fluorescent probe and photosensitiser based on a self-quenched phthalocyanine dimer

(2012) Mei-Rong Ke et al.   CHEMICAL COMMUNICATIONS

Cyclometalated iridium(iii) polypyridine dibenzocyclooctyne complexes as the first phosphorescent bioorthogonal probes

(2012) Kenneth Kam-Wing Lo et al.   CHEMICAL COMMUNICATIONS

Photofunctional triplet excited states of cyclometalated Ir(iii) complexes: beyond electroluminescence

(2012) Youngmin You et al.   CHEMICAL SOCIETY REVIEWS

Lighting the way to see inside the live cell with luminescent transition metal complexes

(2012) Elizabeth Baggaley et al.   COORDINATION CHEMISTRY REVIEWS

Apoptotic cell death induced by 5-aminolaevulinic acid-mediated photodynamic therapy of hypertrophic scar-derived fibroblasts

(2012) Xin Li et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

(2011) Xianchun Zhu et al.   CHEMICAL COMMUNICATIONS

Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

(2011) Anja Kastl et al.   CHEMICAL COMMUNICATIONS

Cell death via mitochondrial apoptotic pathway due to activation of Bax by lysosomal photodamage

(2011) Lei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphorescent Sensor for Robust Quantification of Copper(II) Ion

(2011) Youngmin You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Nonemissive Iridium(III) Complex That Specifically Lights-Up the Nuclei of Living Cells

(2011) Chunyan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted photodynamic therapy – a promising strategy of tumor treatment

(2011) Andrzej M. Bugaj   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Cell Death Pathways in Photodynamic Therapy of Cancer

(2011) Pawel Mroz et al.   Cancers

Discovery, Structure, and Anticancer Activity of an Iridium Complex of Diselenobenzoquinone

(2010) Hani Amouri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trapping Unstable Benzoquinone Analogues by Coordination to a [(η5-C5Me5)Ir] Fragment and the Anticancer Activity of the Resulting Complexes

(2010) Christian G. Hartinger   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium Complex with Antiangiogenic Properties

(2010) Alexander Wilbuer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combating apoptosis and multidrug resistant cancers by targeting lysosomes

(2010) Line Groth-Pedersen et al.   CANCER LETTERS

The time domain in co-stained cell imaging: time-resolved emission imaging microscopy using a protonatable luminescent iridium complex

(2010) Lisa Murphy et al.   CHEMICAL COMMUNICATIONS

Activatable Photosensitizers for Imaging and Therapy

(2010) Jonathan F. Lovell et al.   CHEMICAL REVIEWS

Fluorescent Indicators for Intracellular pH

(2009) Junyan Han et al.   CHEMICAL REVIEWS

Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75

(2009) Melanie Mediavilla-Varela et al.   Molecular Cancer

Conversion from ILCT to LLCT/MLCT Excited State by Heavy Metal Ion Binding in Iridium(III) Complexes with Functionalized 2,2′-Bipyridyl Ligands

(2009) Na Zhao et al.   ORGANOMETALLICS

Exploitation of the Dual-emissive Properties of Cyclometalated Iridium(III)–Polypyridine Complexes in the Development of Luminescent Biological Probes

(2008) Kenneth Kam-Wing Lo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lysosomal involvement in cell death and cancer

(2008) Thomas Kirkegaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY