Qingre Huazhuo Jiangsuan Decoction promotes autophagy by inhibiting PI3K/AKT/mTOR signaling pathway to relieve acute gouty arthritis

3β,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from Cyclocarya paliurus Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy

(2022) Dongxiao Lou et al.   Evidence-based Complementary and Alternative Medicine

Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy

(2022) Mei-Hua Piao et al.   INFLAMMOPHARMACOLOGY

Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway

(2022) Junjie Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes

(2021) Weimin Fan et al.   Journal of Inflammation Research

WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway

(2021) Xin Ba et al.   Frontiers in Pharmacology

Chinese herbal medicine for gout: a review of the clinical evidence and pharmacological mechanisms

(2020) Xiansu Chi et al.   Chinese Medicine

CXCR3 antagonist AMG487 inhibits glucocorticoid-induced tumor necrosis factor-receptor-related protein and inflammatory mediators in CD45 expressing cells in collagen-induced arthritis mouse model

(2020) Saleh A. Bakheet et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CXC chemokine receptor 3 antagonist AMG487 shows potent anti-arthritic effects on collagen-induced arthritis by modifying B cell inflammatory profile

(2020) Saleh A. Bakheet et al.   IMMUNOLOGY LETTERS

Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients

(2019) Qi-Bin Yang et al.   INFLAMMOPHARMACOLOGY

MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling

(2019) Chen Cai et al.   Aging-US

Saponins from Clematis mandshurica Rupr. regulates gut microbiota and its metabolites during alleviation of collagen-induced arthritis in rats

(2019) Lin-Xiu Guo et al.   PHARMACOLOGICAL RESEARCH

Anti-Arthritic Activities of Supercritical Carbon Dioxide Extract Derived from Radiation Mutant Perilla Frutescens Var. Crispa in Collagen Antibody-Induced Arthritis

(2019) Chang Hyun Jin et al.   Nutrients

Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis

(2018) Fa-Bo Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

(2018) Jiali Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Blocking fatty acid–fueled mROS production within macrophages alleviates acute gouty inflammation

(2018) Christopher J. Hall et al.   JOURNAL OF CLINICAL INVESTIGATION

Biochanin a Enhances the Defense Against Salmonella enterica Infection Through AMPK/ULK1/mTOR-Mediated Autophagy and Extracellular Traps and Reversing SPI-1-Dependent Macrophage (MΦ) M2 Polarization

(2018) Xingchen Zhao et al.   Frontiers in Cellular and Infection Microbiology

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis

(2017) Sheikh Fayaz Ahmad et al.   IMMUNOBIOLOGY

Caffeic acid alleviates inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes by inhibiting phosphorylation of IκB kinase α/β and IκBα

(2017) Weifeng Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effectors of mTOR-autophagy pathway: targeting cancer, affecting the skeleton

(2016) Andrei S Chagin   CURRENT OPINION IN PHARMACOLOGY

Non-surgical treatments for the management of early osteoarthritis

(2016) Giuseppe Filardo et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

The tyrosine kinase inhibitor tyrphostin AG126 reduces activation of inflammatory cells and increases Foxp3 + regulatory T cells during pathogenesis of rheumatoid arthritis

(2016) Sheikh Fayaz Ahmad et al.   MOLECULAR IMMUNOLOGY

PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma

(2015) Mirela S. Petrulea et al.   CANCER TREATMENT REVIEWS

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model

(2014) Sheikh Fayaz Ahmad et al.   CYTOKINE

Role of p62/SQSTM1 in liver physiology and pathogenesis

(2013) Sharon Manley et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Beclin1: A role in membrane dynamics and beyond

(2012) Ellen Wirawan et al.   Autophagy

TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts

(2012) Alison M Connor et al.   ARTHRITIS RESEARCH & THERAPY

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

(2011) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Constituents and Pharmacological Properties ofPoria cocos

(2011) José-Luis Ríos   PLANTA MEDICA

The pathogenesis of bone erosions in gouty arthritis

(2010) N. Schlesinger et al.   ANNALS OF THE RHEUMATIC DISEASES

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Developments in the scientific and clinical understanding of gout

(2008) Alexander So   ARTHRITIS RESEARCH & THERAPY