Article
Immunology
Sheikh F. Ahmad, Ahmed Nadeem, Mushtaq A. Ansari, Saleh A. Bakheet, Hatun A. Alomar, Haneen A. Al-Mazroua, Khalid E. Ibrahim, Ali A. Alshamrani, Mohammed A. Al-Hamamah, Ali S. Alfardan, Sabry M. Attia
Summary: In this study, the CXCR3-specific antagonist NBI-74330 was used to inhibit T-cell-mediated signaling in a mouse model of rheumatoid arthritis (RA). The results showed that NBI-74330 treatment significantly reduced arthritis symptoms and histopathological changes. Additionally, NBI-74330 treatment downregulated the percentages and gene expression levels of Th1, Th17, and Th22 cells. These findings suggest that NBI-74330 has potential as a treatment for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Yunhui Min, Yunji Heo, Fang Feng, Dahye Kim, Mangeun Kim, Jiwon Yang, Hyo Jin Kim, Youngheun Jee, Mrinmoy Ghosh, Inhae Kang, Young-Ok Son
Summary: Excessive consumption of sucrose leads to hepatic fibrosis and inflammation, increasing the risk of rheumatoid arthritis (RA) pathogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Immunology
Hao Yuan, Si-Xian Wu, Yi-Feng Zhou, Fang Peng
Summary: The study demonstrates that SPD can protect CIA mice by inhibiting the polarization of M1 macrophages, reducing pro-inflammatory cytokines, and promoting the release of anti-inflammatory factors.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Sabry M. Attia, Mudassar Shahid, Faris S. Alyousef, Mohammed A. Alswailem, Mohammed Alqinyah, Sheikh F. Ahmad
Summary: This study demonstrates that MVC has therapeutic potential in attenuating the severity of inflammatory arthritis in CIA mice by reducing pro-inflammatory responses and increasing anti-inflammatory responses.
Article
Immunology
G. Halpert, I. Katz, O. Shovman, S. Tarasov, K. K. Ganina, N. Petrova, M. Tocut, A. Volkov, I. Barshack, M. Blank, H. Amital
Summary: Treatment with IVIG significantly reduced clinical arthritis score in DBA/1j mice with collagen-induced arthritis. IVIG showed a mode of action by decreasing circulating levels of inflammatory cytokines and inhibiting anti-collagen antibodies. Histopathological examination revealed that IVIG treatment prevented inflammatory immune cells from migrating into cartilage and synovium, reducing joint damage and preserving joint architecture. These results suggest the valuable anti-inflammatory treatment of IVIG in experimental RA.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kaja Kasarello, Iwona Koehling, Anna Kosowska, Katarzyna Pucia, Anna Lukasik, Agnieszka Cudnoch-Jedrzejewska, Leszek Paczek, Urszula Zielenkiewicz, Piotr Zielenkiewicz
Summary: Cross-kingdom gene expression regulation by xenomiRs, particularly from plants, has been found to have potential scientific significance. In this study, miR172a derived from Brassica oleracea was shown to decrease the levels of FAN protein in human and mouse cells. Furthermore, treatment with miR172a was found to mitigate inflammation in a mouse model of rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Ju-Young Kim, Yoon-Hee Cheon, Sung-Jun Ahn, Sung Chul Kwak, Chong Hyuk Chung, Chang Hoon Lee, Myeung Su Lee
Summary: The study demonstrates the beneficial effects of HAR on local symptoms and systemic bone erosion triggered by inflammatory arthritis, showing reduced clinical scores and incidence rates of CIA, localized improvements in bone and cartilage destruction, and inhibition of inflammatory cytokines expression.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Multidisciplinary Sciences
Richard Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Summary: This study characterizes clusters of RA cell lines with distinctive TF biology by integrating transcriptomic and epigenomic data and validates the predicted differences.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Takashi Nawata, Hiroki Sakai, Takeshi Honda, Marina Otsuka, Hina Fujita, Hitoshi Uchinoumi, Shigeki Kobayashi, Takeshi Yamamoto, Masataka Asagiri, Masafumi Yano
Summary: Dantrolene inhibits Ca2+ leakage from destabilized ryanodine receptors and shows potential as a therapeutic agent against endoplasmic reticulum stress-associated diseases. In a mouse model of collagen-induced arthritis, oral administration of dantrolene significantly reduces arthritic scores, suppresses bone and chondral destruction, and inhibits the production of serum anti-type II collagen IgG. These findings suggest that dantrolene may be a potential anti-rheumatic drug.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Yaling Tian, Ping Shi, Yan Zhou, Rui Yuan, Zhicheng Hu, Yan Tan, Guilan Ma, Lei Yang, Hongmei Jiang
Summary: The study successfully constructed tolDCs, and found that they had long-term tolerogenic potential in vivo, which could improve arthritis in CIA rats with different severity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yue Zhang, Hui Wang, Yi-Nan Gong, Fu-Ming Yang, Shen-Jun Wang, Yang-Yang Liu, Yong-Qing Gui, Fei Xie, Zhi-Fang Xu, Yi Guo
Summary: It is unclear whether acupuncture can promote repair in rheumatoid arthritis, but research suggests that it has anti-inflammatory and analgesic effects, improves joint function, and delays disease progression. This study found that acupuncture improves joint swelling, pain, and inflammation by modulating steroid hormone synthesis, cell metabolism, and tissue repair processes. Acupuncture may alleviate rheumatoid arthritis in the joints by modulating tissue healing.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Dorra Elhaj Mahmoud, Wajih Kaabachi, Nadia Sassi, Amel Mokhtar, Myriam Moalla, Lobna Ben Ammar, Samia Jemmali, Sonia Rekik, Lamjed Tarhouni, Maryam Kallel-Sellami, Elhem Cheour, Lilia Laadhar
Summary: RA td-FLS, fd-FLS, and fibrocytes from patients express similar levels of Wnt5a and its receptors/coreceptors. Wnt5a stimulates pro-inflammatory targets in RA td-FLS, especially IL1 beta, IL8, and IL6, and this inflammation is enhanced in the presence of SFRP5. Additionally, Wnt5a and SFRP5 inhibit the expression of TCF4 and the canonical coreceptor LRP5.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hatun A. Alomar, Mushtaq A. Ansari, Ahmed Nadeem, Sabry M. Attia, Saleh A. Bakheet, Haneen A. Al-Mazroua, Marwa H. Hussein, Saleh A. Alqarni, Sheikh F. Ahmad
Summary: This study investigated the anti-inflammatory effect of the CXCR2 antagonist SB332235 in BTBR mice, showing that SB332235 elicits an anti-inflammatory response by downregulating inflammatory mediators and NF-kappa B/Notch inflammatory signaling. This could represent a promising novel therapeutic target for autism treatment.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Samiyah Alshehri, Ahmed Nadeem, Sheikh F. Ahmad, Sana S. Alqarni, Naif O. Al-Harbi, Laila Y. Al-Ayadhi, Sabry M. Attia, Saleh A. Alqarni, Saleh A. Bakheet
Summary: Autism spectrum disorder (ASD) is a childhood neuropsychiatric disorder that affects social skill and language development. This study explores the dysregulation of the redox couple TrxR1/Trx1 in T cells of ASD subjects, which is associated with decreased Bcl2 expression and increased apoptosis. The findings suggest that T cells in ASD subjects may have decreased survival during chronic inflammation. Future studies should investigate environmental factors that may contribute to abnormal immune responses in ASD subjects.
Article
Environmental Sciences
Mohammad M. Algahtani, Sheikh F. Ahmad, Layla A. Alkharashi, Naif O. Al-Harbi, Wael A. Alanazi, Abdullah S. Alhamed, Sabry M. Attia, Saleh A. Bakheet, Khalid E. Ibrahim, Ahmed Nadeem
Summary: Autism spectrum disorder (ASD) is a complex developmental condition characterized by behavioral patterns and impairments in social and vocalization abilities. Methylmercury, a toxic environmental pollutant, is a major source of organic mercury in humans. Exposure to methylmercury through the consumption of fish and shellfish increases the risk of developing ASD by disrupting the oxidant-antioxidant balance. This study evaluated the effect of juvenile exposure to methylmercury chloride on autism-like behavior and oxidant-antioxidant balance in adult mice. The results showed that exposure to methylmercury chloride during the juvenile stage resulted in autism-like symptoms and oxidative inflammation in adult mice, suggesting the importance of Nrf2 signaling pathway in countering the worsening of ASD.
Article
Biochemistry & Molecular Biology
Varinder Singh, Somdutt Mujwar, Manjinder Singh, Tanveer Singh, Sheikh F. Ahmad
Summary: This manuscript presents a computational protocol to uncover the underlying mechanism of action of basil compounds in neuroprotective effects. The molecular docking and molecular dynamics simulations indicate that specific basil compounds may play important roles in modulating various neurobiological processes, providing a rationale for their therapeutic use in neurodegenerative disorders.
Article
Biochemistry & Molecular Biology
Shashanka K. Prasad, Smitha S. Bhat, Olga Koskowska, Jiraporn Sangta, Sheikh F. Ahmad, Ahmed Nadeem, Sarana Rose Sommano
Summary: A study found that a phytochemical in coffee pulp called Naringin showed strong antifungal activity against the foodborne fungus Aspergillus fumigatus. Naringin was also shown to have good oral bioavailability. Toxicity predictions indicated that Naringin is safe for human consumption and could be used to develop antifungal treatments and food packaging materials. This study addresses the issues of coffee waste management and antifungal resistance.
Article
Neurosciences
Mohammad Y. Alwetaid, Taghreed N. Almanaa, Saleh A. Bakheet, Mushtaq A. Ansari, Ahmed Nadeem, Sabry M. Attia, Marwa H. Hussein, Sheikh F. Ahmad
Summary: This study investigated the impact of AFB(1) exposure on behavior and immune responses in BTBR mice. The results showed that AFB(1) exposure led to an exacerbation of behavioral abnormalities and an upregulation of immune-related factors. These findings underscore the significance of AFB(1) in the development of ASD.
Article
Biochemistry & Molecular Biology
K. Monisha, S. Mahema, M. Chokkalingam, Sheikh F. Ahmad, Talha Bin Emran, Paramasivam Prabu, Shiek S. S. J. Ahmed
Summary: This study aimed to investigate the expression of HDAC genes in coronary artery disease (CAD) and evaluate their impact on hematological, biochemical, and echocardiographic indices. The researchers found that certain HDACs were upregulated in CAD patients and significantly associated with various physiological parameters. Additionally, a diagnostic model using key HDACs showed excellent accuracy in distinguishing CAD from the control group.
Article
Biochemistry & Molecular Biology
Layla A. Al-Kharashi, Naif O. Al-Harbi, Sheikh F. Ahmad, Sabry M. Attia, Mohammad M. Algahtani, Khalid E. Ibrahim, Saleh A. Bakheet, Mohammed M. Alanazi, Saleh A. Alqarni, Sary Alsanea, Ahmed Nadeem
Summary: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease that causes demyelination of neurons and degeneration of the central nervous system. This study explored the effects of the gold compound auranofin (AFN) on a mouse model of relapsing-remitting MS (RRMS). The results showed that AFN improved the clinical features of RRMS by regulating the levels of antioxidants and inhibiting the production of oxidative/inflammatory mediators.
Article
Biochemistry & Molecular Biology
Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akash, Ahmed Nadeem, Tahir Maqbool Mir
Summary: This study aimed to investigate the potential protective effects of metformin and vitamin E against AlCl3-induced neuroinflammation and cardiometabolic disturbances. The results showed that the combination therapy of metformin and vitamin E significantly reduced glucose, cholesterol, and triglyceride levels and increased insulin and high-density lipoprotein levels. Moreover, the combination therapy preserved neuronal structures and normal morphology in brain, heart, and pancreatic tissues.
Article
Environmental Sciences
Samiyah Alshehri, Sheikh F. Ahmad, Norah A. Albekairi, Sana S. Alqarni, Naif O. Al-Harbi, Laila Y. Al-Ayadhi, Sabry M. Attia, Ali S. Alfardan, Saleh A. Bakheet, Ahmed Nadeem
Summary: Autism spectrum disorder (ASD) is a complex developmental disorder in children that is associated with exposure to heavy metals. Methylmercury may elevate systemic oxidative inflammation in ASD patients through dysregulation of the Trx1/TrxR1 redox system in neutrophils.
Article
Multidisciplinary Sciences
Hassan Ali, Hafiz Usman, Waseem Ashraf, Faleh Alqahtani, Sana Javaid, Farhan Siddique, Muhammad Fawad Rasool, Imran Imran, Tanveer Ahmad, Anas M. Abdel Rahman, Reem H. Almalki
Summary: This study scientifically validates the neuroprotective effects of the herbal product Demaghi, which is claimed to have memory-enhancing properties. The results show that Demaghi reduces anxiety and depression and improves memory in a mouse model of memory deficiency induced by AlCl3. Biochemical analysis also indicates a decrease in oxidative stress and histopathological changes in treated animals. These findings suggest that the phytoconstituents in Demaghi enhance cholinergic neurotransmission and protect against neurotoxin-induced oxidative stress.
Article
Biochemistry & Molecular Biology
Dhafer Y. Alhareth, Abdulrazaq Alanazi, Wael A. Alanazi, Mushtaq A. Ansari, Mahmoud N. Nagi, Sheikh F. Ahmad, Mohamed S. M. Attia, Ahmed Nadeem, Saleh A. Bakheet, Sabry M. Attia
Summary: This study found that the proteasome inhibitor carfilzomib can protect against acute liver failure (ALF) induced by LPS/GalN/DMSO in mice by inhibiting NF-kB, reducing inflammatory mediators, oxidative stress, and apoptosis, suggesting its potential as a therapeutic agent for ALF.
Article
Biochemistry & Molecular Biology
Narhari Gangaram Yedke, Shubham Upadhayay, Randhir Singh, Sumit Jamwal, Sheikh F. Ahmad, Puneet Kumar
Summary: The study aimed to confirm the neuroprotective effect of the BCG vaccine on haloperidol-induced tardive dyskinesia (TD)-like symptoms in rats. The results showed that the BCG vaccine reversed orofacial dyskinesia and improved motor function. Additionally, it increased the levels of antioxidant enzymes, reduced oxidative stress and apoptotic markers, and restored neurotransmitter levels.
Article
Biochemistry & Molecular Biology
Yeruva Sai Lakshmi, D. S. N. B. K. Prasanth, Karumuri Taraka Sunil Kumar, Sheikh F. Ahmad, Seemaladinne Ramanjaneyulu, Nalluri Rahul, Praveen Kumar Pasala
Summary: The development of effective drugs for Parkinson's disease is urgently needed due to its significant burden on society. In this study, Quercetin nanocrystals (QNC) were synthesized and analyzed using a network-pharmacology-based methodology. The results showed that QNC can regulate the targets relevant to Parkinson's disease and has better binding affinity compared to the standard drug. Furthermore, QNC effectively reduced the adverse effects caused by rotenone-induced oxidative stress. These findings suggest that QNC has the potential to be a promising treatment for Parkinson's disease.
Article
Endocrinology & Metabolism
Aarif Ali, Bashir Ahmad Malla, Nouroz Sehar, Sheikh Bilal Ahmad, Zuha Imtiyaz, Azher Arafah, Muneeb U. Rehman, Ahmed Nadeem
Summary: In this study, various plant bioactives were explored as potential inhibitors against the Parkin gene using computational based approaches. The findings suggest that Cytochalasin E could be repurposed as a potential inhibitor targeting Parkin. Further studies are needed to validate these results.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)