A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway

Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Boris Bikbov et al.   LANCET

A bioinformatics and network pharmacology approach to the mechanisms of action of Shenxiao decoction for the treatment of diabetic nephropathy

(2020) Xin Mou et al.   PHYTOMEDICINE

HUANGKUISIWUFANG inhibits pyruvate dehydrogenase to improve glomerular injury in anti-Thy1 nephritis model

(2020) Ting Lu et al.   JOURNAL OF ETHNOPHARMACOLOGY

A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis

(2020) Miao-Juan Shi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy

(2020) Enyu Wang et al.   PHARMACOLOGICAL RESEARCH

From single drug targets to synergistic network pharmacology in ischemic stroke

(2019) Ana I. Casas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting metabolic dysregulation for fibrosis therapy

(2019) Xiao Zhao et al.   NATURE REVIEWS DRUG DISCOVERY

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search

(2016) Noa Rappaport et al.   NUCLEIC ACIDS RESEARCH

Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro

(2016) GUANG SHAN et al.   Experimental and Therapeutic Medicine

Glycogen synthase kinase 3 in Wnt signaling pathway and cancer

(2015) Nydia Tejeda-Muñoz et al.   IUBMB LIFE

Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice

(2015) Wei-Jian Zhang et al.   MEDIATORS OF INFLAMMATION

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

(2015) Lili Zhou et al.   Nature Reviews Nephrology

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

(2015) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Sequential RAAS Blockade: Is It Worth the Risk?

(2014) Frederik Persson et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro

(2014) Li Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

DAVID-WS: a stateful web service to facilitate gene/protein list analysis

(2012) X. Jiao et al.   BIOINFORMATICS

Astragaloside IV, a Novel Antioxidant, Prevents Glucose-Induced Podocyte Apoptosis In Vitro and In Vivo

(2012) Dingkun Gui et al.   PLoS One

Ligand docking and binding site analysis with PyMOL and Autodock/Vina

(2010) Daniel Seeliger et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

TGF-β and fibrosis in different organs — molecular pathway imprints

(2009) Dirk Pohlers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Activation of Erk1/2 and Akt following unilateral ureteral obstruction

(2008) Ana B. Rodríguez-Peña et al.   KIDNEY INTERNATIONAL