New concepts in antimicrobial resistance in cystic fibrosis respiratory infections

Tolerance and resistance of microbial biofilms

(2022) Oana Ciofu et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial biofilms predominate in both acute and chronic human lung infections

(2022) Mette Kolpen et al.   THORAX

Establishing antimicrobial susceptibility testing methods and clinical breakpoints for inhaled antibiotic therapy

(2022) Miquel B Ekkelenkamp et al.   Open Forum Infectious Diseases

Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection

(2022) Jerry A. Nick et al.   CELL

How to: ECOFFs—the why, the how, and the don'ts of EUCAST epidemiological cutoff values

(2022) Gunnar Kahlmeter et al.   CLINICAL MICROBIOLOGY AND INFECTION

Decreased efficacy of antimicrobial agents in a polymicrobial environment

(2022) Thomas James O’Brien et al.   ISME Journal

Transmission and antibiotic resistance of Achromobacter in cystic fibrosis

(2021) Migle Gabrielaite et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A Case of Phage Therapy against Pandrug-Resistant Achromobacter xylosoxidans in a 12-Year-Old Lung-Transplanted Cystic Fibrosis Patient

(2021) David Lebeaux et al.   Viruses-Basel

Ceftolozane/tazobactam for Pseudomonas aeruginosa pulmonary exacerbations in cystic fibrosis adult patients: a case series

(2021) Letizia Ottino et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

The quorum sensing inhibitor furanone C-30 rapidly loses its tobramycin potentiating activity against Pseudomonas aeruginosa biofilms during experimental evolution

(2021) Mona Bové et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Update From The European Committee On Antimicrobial Suseptibility Testing (EUCAST)

(2021) Christian G. Giske et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The importance of understanding the infectious microenvironment

(2021) Thomas Bjarnsholt et al.   LANCET INFECTIOUS DISEASES

Optimization of antibiotics for cystic fibrosis pulmonary exacerbations due to highly resistant nonlactose fermenting Gram negative bacilli: Meropenem‐vaborbactam and cefiderocol

(2021) Rachel Belcher et al.   PEDIATRIC PULMONOLOGY

The cystic fibrosis lung microenvironment alters antibiotic activity: causes and effects

(2021) Sara Van den Bossche et al.   European Respiratory Review

Organic Acids and Their Salts Potentiate the Activity of Selected Antibiotics against Pseudomonas aeruginosa Biofilms Grown in a Synthetic Cystic Fibrosis Sputum Medium

(2021) Xuerui Bao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

European regulatory aspects of phage therapy: magistral phage preparations

(2021) Gilbert Verbeken et al.   Current Opinion in Virology

Variable Susceptibility to Gallium Compounds of Major Cystic Fibrosis Pathogens

(2021) Daniela Visaggio et al.   ACS Infectious Diseases

Finding the relevance of antimicrobial stewardship for cystic fibrosis

(2020) Jonathan D. Cogen et al.   Journal of Cystic Fibrosis

Antimicrobial resistance: Concerns of healthcare providers and people with CF

(2020) Wendy Bullington et al.   Journal of Cystic Fibrosis

Maintenance tobramycin primarily affects untargeted bacteria in the CF sputum microbiome

(2020) Maria T Nelson et al.   THORAX

Omics-based tracking of Pseudomonas aeruginosa persistence in “eradicated” CF patients

(2020) Jennifer A. Bartell et al.   EUROPEAN RESPIRATORY JOURNAL

Cefiderocol for the Treatment of Adult and Pediatric Patients with Cystic Fibrosis and Achromobacter xylosoxidans Infections

(2020) Nathaniel C Warner et al.   CLINICAL INFECTIOUS DISEASES

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

(2020) Elio Rossi et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial persisters in long-term infection: Emergence and fitness in a complex host environment

(2020) Jennifer A. Bartell et al.   PLoS Pathogens

Evolutionary highways to persistent bacterial infection

(2019) Jennifer A. Bartell et al.   Nature Communications

Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients

(2019) Signe Agnete Møller et al.   Journal of Cystic Fibrosis

Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria

(2019) Kaitlyn E. Kortright et al.   Cell Host & Microbe

Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in Burkholderia cenocepacia Biofilms

(2019) Andrea Sass et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reconciling Antimicrobial Susceptibility Testing and Clinical Response in Antimicrobial Treatment of Chronic Cystic Fibrosis Lung Infections

(2019) Valerie J Waters et al.   CLINICAL INFECTIOUS DISEASES

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics

(2019) Aurélie Crabbé et al.   PLoS Pathogens

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

(2019) Oana Ciofu et al.   Frontiers in Microbiology

Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

(2019) Aurélie Crabbé et al.   TRENDS IN MICROBIOLOGY

Antimicrobial resistance in cystic fibrosis: A Delphi approach to defining best practices

(2019) Edith Zemanick et al.   Journal of Cystic Fibrosis

Interplay between host-microbe and microbe-microbe interactions in cystic fibrosis

(2019) Catherine R. Armbruster et al.   Journal of Cystic Fibrosis

Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate

(2019) Yehuda Halfon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low penetrance of antibiotics in the epithelial lining fluid. The role of inhaled antibiotics in patients with bronchiectasis

(2019) Theodoros Karampitsakos et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections

(2018) Lejla Imamovic et al.   CELL

ECFS best practice guidelines: the 2018 revision

(2018) Carlo Castellani et al.   Journal of Cystic Fibrosis

Defining antimicrobial resistance in cystic fibrosis

(2018) Timothy J. Kidd et al.   Journal of Cystic Fibrosis

The Coming of Age of Drug-Susceptibility Testing for Tuberculosis

(2018) Helen Cox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

(2018) Christopher H. Goss et al.   Science Translational Medicine

Mutations causing low level antibiotic resistance ensure bacterial survival in antibiotic-treated hosts

(2018) Jakob Frimodt-Møller et al.   Scientific Reports

The potential of phage therapy in cystic fibrosis: Essential human-bacterial-phage interactions and delivery considerations for use in Pseudomonas aeruginosa -infected airways

(2017) Stephanie Trend et al.   Journal of Cystic Fibrosis

Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis

(2017) Robert P. Howlin et al.   MOLECULAR THERAPY

Optimization of anti-pseudomonal antibiotics for cystic fibrosis pulmonary exacerbations: II. Cephalosporins and penicillins update

(2017) Jeffery T. Zobell et al.   PEDIATRIC PULMONOLOGY

The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

(2017) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients

(2017) Krisztina M. Papp-Wallace et al.   ACS Infectious Diseases

The effects of inhaled aztreonam on the cystic fibrosis lung microbiome

(2017) Alya A. Heirali et al.   Microbiome

Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment

(2016) Mette Kolpen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients

(2015) Yvonne C.W. Yau et al.   Journal of Cystic Fibrosis

Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis

(2015) Phelim Bradley et al.   Nature Communications

High variability in quorum quenching and growth inhibition by furanone C-30 inPseudomonas aeruginosaclinical isolates from cystic fibrosis patients

(2015) Rodolfo García-Contreras et al.   Pathogens and Disease

Pseudomonas aeruginosa in Cystic Fibrosis Patients With G551D-CFTR Treated With Ivacaftor

(2014) Sonya L. Heltshe et al.   CLINICAL INFECTIOUS DISEASES

Antimicrobial susceptibility testing in biofilm-growing bacteria

(2014) M.D. Macia et al.   CLINICAL MICROBIOLOGY AND INFECTION

Localization of Burkholderia cepacia Complex Bacteria in Cystic Fibrosis Lungs and Interactions with Pseudomonas aeruginosa in Hypoxic Mucus

(2014) Ute Schwab et al.   INFECTION AND IMMUNITY

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

(2014) Lisa Saiman et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Antimicrobial resistance in the respiratory microbiota of people with cystic fibrosis

(2014) Laura J Sherrard et al.   LANCET

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

Novel outcome measures for clinical trials in cystic fibrosis

(2014) Harm A.W.M. Tiddens et al.   PEDIATRIC PULMONOLOGY

Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms

(2014) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Biofilm-Grown Burkholderia cepacia Complex Cells Survive Antibiotic Treatment by Avoiding Production of Reactive Oxygen Species

(2013) Heleen Van Acker et al.   PLoS One

Mannitol Enhances Antibiotic Sensitivity of Persister Bacteria in Pseudomonas aeruginosa Biofilms

(2013) Nicolas Barraud et al.   PLoS One

The in vivo biofilm

(2013) Thomas Bjarnsholt et al.   TRENDS IN MICROBIOLOGY

Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil inPseudomonas aeruginosaclinical isolates

(2013) Rodolfo García-Contreras et al.   Pathogens and Disease

Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria

(2012) Jakko van Ingen et al.   DRUG RESISTANCE UPDATES

Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment ofPseudomonas aeruginosabiofilm infections

(2012) Oana Ciofu et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

In vitro prevention of Pseudomonas aeruginosa early biofilm formation with antibiotics used in cystic fibrosis patients

(2012) Ana Fernández-Olmos et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

(2012) L. D. Christensen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Treatment of lung infection in patients with cystic fibrosis: Current and future strategies

(2012) Gerd Döring et al.   Journal of Cystic Fibrosis

Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis

(2012) M.N. Hurley et al.   Journal of Cystic Fibrosis

Decade-long bacterial community dynamics in cystic fibrosis airways

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

(2011) Gilles Brackman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial hypermutation in cystic fibrosis, not only for antibiotic resistance

(2010) A. Oliver et al.   CLINICAL MICROBIOLOGY AND INFECTION

Randomized trial of biofilm testing to select antibiotics for cystic fibrosis airway infection

(2010) Samuel M. Moskowitz et al.   PEDIATRIC PULMONOLOGY

Pseudomonas aeruginosabiofilms in the respiratory tract of cystic fibrosis patients

(2009) Thomas Bjarnsholt et al.   PEDIATRIC PULMONOLOGY