Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products
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Title
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products
Authors
Keywords
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Journal
JOURNAL OF CONTROLLED RELEASE
Volume 351, Issue -, Pages 215-230
Publisher
Elsevier BV
Online
2022-09-23
DOI
10.1016/j.jconrel.2022.09.031
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Note: Only part of the references are listed.- A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes
- (2022) Marwa M. El Sayed et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Moderna COVID-19 Vaccine — United States, December 21, 2020–January 10, 2021
- (2021) et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- BNT162b2 mRNA COVID-19 Vaccine: First Approval
- (2021) Yvette N. Lamb DRUGS
- Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021
- (2021) Tom T. Shimabukuro et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- PEG That Reaction: A Case Series of Allergy to Polyethylene Glycol
- (2021) Fionnuala Cox et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID‐19 vaccine
- (2021) Priya Sellaturay et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines
- (2021) Kelsey L. Swingle et al. TRENDS IN MOLECULAR MEDICINE
- Pegcetacoplan: First Approval
- (2021) Sheridan M. Hoy DRUGS
- Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice
- (2021) Sherif E. Emam et al. JOURNAL OF CONTROLLED RELEASE
- Safety and effectiveness of SARS‐CoV‐2 vaccines: A systematic review and meta‐analysis
- (2021) Yunzhi Ling et al. JOURNAL OF MEDICAL VIROLOGY
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months
- (2021) Stephen J. Thomas et al. NEW ENGLAND JOURNAL OF MEDICINE
- Editorial: First Full Regulatory Approval of a COVID-19 Vaccine, the BNT162b2 Pfizer-BioNTech Vaccine, and the Real-World Implications for Public Health Policy
- (2021) Dinah V. Parums MEDICAL SCIENCE MONITOR
- First-Dose mRNA COVID-19 Vaccine Allergic Reactions: Limited Role for Excipient Skin Testing
- (2021) Anna R. Wolfson et al. Journal of Allergy and Clinical Immunology-In Practice
- Lonapegsomatropin: Pediatric First Approval
- (2021) Yvette N. Lamb PEDIATRIC DRUGS
- Immunogenicity Risk Assessment for PEGylated Therapeutics
- (2020) Johanna R. Mora et al. AAPS Journal
- Antibodies against polyethylene glycol in human blood: A literature review
- (2020) Lu Hong et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals
- (2020) Gergely Tibor Kozma et al. ADVANCED DRUG DELIVERY REVIEWS
- Pharmacokinetic and Pharmacodynamic Equivalence of Pegfilgrastim-cbqv and Pegfilgrastim in Healthy Subjects
- (2020) Barbara Finck et al. ADVANCES IN THERAPY
- Improving the Treatment of Acute Lymphoblastic Leukemia
- (2020) Ashish Radadiya et al. BIOCHEMISTRY
- Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice
- (2020) Nehal E. Elsadek et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Impact of Pre-Existing or Induced Anti-PEG IgM on the Pharmacokinetics of Peginterferon Alfa-2a (Pegasys) in Mice
- (2020) Nehal E. Elsadek et al. MOLECULAR PHARMACEUTICS
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
- (2020) Kizzmekia S. Corbett et al. NATURE
- PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production
- (2020) Takuya Suzuki et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Polyethylene Glycol–Induced Systemic Allergic Reactions (Anaphylaxis)
- (2020) Priya Sellaturay et al. Journal of Allergy and Clinical Immunology-In Practice
- Allergic reactions to the first COVID‐19 vaccine: a potential role of Polyethylene glycol?
- (2020) Beatriz Cabanillas et al. ALLERGY
- Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit?
- (2020) Lene H. Garvey et al. BRITISH JOURNAL OF ANAESTHESIA
- FIXing postinfusion monitoring: Assay experiences with N9-GP (nonacog beta pegol; Refixia® ; Rebinyn® )
- (2019) Mirella Ezban et al. HAEMOPHILIA
- Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review
- (2019) Kouichi Shiraishi et al. SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
- Pseudo-Anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions
- (2019) Gergely Tibor Kozma et al. ACS Nano
- PEGylated E. coli asparaginase desensitization: an effective and feasible option for pediatric patients with acute lymphoblastic leukemia who have developed hypersensitivity to pegaspargase in the absence of asparaginase Erwinia chrysanthemi availability
- (2019) Anupam Verma et al. PEDIATRIC HEMATOLOGY AND ONCOLOGY
- PEGylated liposomes: immunological responses
- (2019) Marwa Mohamed et al. SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
- FDA Approval Summary: Calaspargase Pegol-mknl For Treatment of Acute Lymphoblastic Leukemia in Children and Young Adults
- (2019) Ruo-Jing Li et al. CLINICAL CANCER RESEARCH
- A cautionary note: Toxicity of polyethylene glycol 200 injected intraperitoneally into mice
- (2019) Wilko Thiele et al. LABORATORY ANIMALS
- Classification of hypersensitivity reactions
- (2019) Melanie C. Dispenza ALLERGY AND ASTHMA PROCEEDINGS
- 1815PRandomized, double-blind, cross-over phase I study comparing pharmacokinetics, pharmacodynamics, safety and immunogenicity of a biosimilar pegfilgrastim with EU and US references
- (2019) M Velinova et al. ANNALS OF ONCOLOGY
- Polyethylene glycol: an underrecognized compound in certolizumab pegol and Movicol that may cause anaphylaxis
- (2019) Eva McCabe et al. RHEUMATOLOGY
- An overview of turoctocog alfa pegol (N8‐GP; ESPEROCT ® ) assay performance: Implications for postadministration monitoring
- (2019) Mirella Ezban et al. HAEMOPHILIA
- Pegvaliase: First Global Approval
- (2018) Anthony Markham BIODRUGS
- Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes
- (2018) Yuan-Chin Hsieh et al. Theranostics
- Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials
- (2018) Soumi Gupta et al. EBioMedicine
- Clinical Characteristics of Intravenous PEG-Asparaginase Hypersensitivity Reactions in Patients Undergoing Treatment for Acute Lymphoblastic Leukemia
- (2017) Emily K. Browne et al. Journal of Pediatric Oncology Nursing
- Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group
- (2017) Rachel E. Rau et al. PEDIATRIC BLOOD & CANCER
- Cytotoxicity study of polyethylene glycol derivatives
- (2017) Guoqiang Liu et al. RSC Advances
- Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population
- (2016) Qi Yang et al. ANALYTICAL CHEMISTRY
- Immediate-type hypersensitivity to polyethylene glycols: a review
- (2016) E. Wenande et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications
- (2016) Anisha A. D’souza et al. Expert Opinion on Drug Delivery
- Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer
- (2016) Thomas J. Povsic et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer
- (2016) Nancy J. Ganson et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs
- (2016) Peter L. Turecek et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Pegaspargase hypersensitivity reactions: intravenous infusion versus intramuscular injection – a review
- (2016) Lynda Kwon Beaupin et al. LEUKEMIA & LYMPHOMA
- Comparison of hypersensitivity rates to intravenous and intramuscular PEG-asparaginase in children with acute lymphoblastic leukemia: A meta-analysis and systematic review
- (2016) Haroon Hasan et al. PEDIATRIC BLOOD & CANCER
- Newly Developed Techniques on Polycondensation, Ring-Opening Polymerization and Polymer Modification: Focus on Poly(Lactic Acid)
- (2016) Yunzi Hu et al. Materials
- Anaphylaxis—a practice parameter update 2015
- (2015) Phillip Lieberman et al. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
- Complement activation as a bioequivalence issue relevant to the development of generic liposomes and other nanoparticulate drugs
- (2015) Janos Szebeni et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- What is the future of PEGylated therapies?
- (2015) Magdalena Swierczewska et al. EXPERT OPINION ON EMERGING DRUGS
- Chemical and Enzymatic Site Specific PEGylation of hGH: The Stability and in vivo Activity of PEG-N-Terminal-hGH and PEG-Gln141-hGH Conjugates
- (2015) Antonella Grigoletto et al. MACROMOLECULAR BIOSCIENCE
- Anti-PEG immunity: emergence, characteristics, and unaddressed questions
- (2015) Qi Yang et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- Hypersensitivity Reactions to Intravenous Lipid Emulsion in Swine
- (2014) Peter Bedocs et al. ANESTHESIA AND ANALGESIA
- Beyond Poly(ethylene glycol): Linear Polyglycerol as a Multifunctional Polyether for Biomedical and Pharmaceutical Applications
- (2014) Anja Thomas et al. BIOMACROMOLECULES
- A simple and general method for preparing antibody-PEG-PLGA sub-micron particles using electrospray technique: An in vitro study of targeted delivery of cisplatin to ovarian cancer cells
- (2014) Meng-Yi Bai et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Identification of multiple cellular uptake pathways of polystyrene nanoparticles and factors affecting the uptake: Relevance for drug delivery systems
- (2014) Rebuma Firdessa et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- The interaction of nanoparticles with plasma proteins and the consequent influence on nanoparticles behavior
- (2014) Huile Gao et al. Expert Opinion on Drug Delivery
- Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses
- (2014) László Dézsi et al. JOURNAL OF CONTROLLED RELEASE
- PEG — A versatile conjugating ligand for drugs and drug delivery systems
- (2014) Atul Kolate et al. JOURNAL OF CONTROLLED RELEASE
- Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial
- (2014) Nicola Longo et al. LANCET
- Complement activation-related pseudoallergy: A stress reaction in blood triggered by nanomedicines and biologicals
- (2014) Janos Szebeni MOLECULAR IMMUNOLOGY
- Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients
- (2014) Michael S Hershfield et al. ARTHRITIS RESEARCH & THERAPY
- Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout
- (2014) Peter E Lipsky et al. ARTHRITIS RESEARCH & THERAPY
- Delayed hypersensitivity reaction related to the use of pegfilgrastim
- (2014) Aliakbar Dadla et al. JOURNAL OF ONCOLOGY PHARMACY PRACTICE
- The influence of lipid composition and surface charge on biodistribution of intact liposomes releasing from hydrogel-embedded vesicles
- (2013) A. Alinaghi et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
- (2013) Amr S. Abu Lila et al. JOURNAL OF CONTROLLED RELEASE
- Effect of DOPE and cholesterol on the protein adsorption onto lipid nanoparticles
- (2013) Giulio Caracciolo et al. JOURNAL OF NANOPARTICLE RESEARCH
- The Immunogenicity of Polyethylene Glycol: Facts and Fiction
- (2013) Huub Schellekens et al. PHARMACEUTICAL RESEARCH
- Overview of Complement Activation and Regulation
- (2013) Marina Noris et al. SEMINARS IN NEPHROLOGY
- Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response
- (2012) Taro Shimizu et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- A case of anaphylaxis caused by macrogol 3350 after injection of a corticosteroid
- (2012) Alicia Borderé et al. CONTACT DERMATITIS
- Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents
- (2012) Ricardo P Garay et al. Expert Opinion on Drug Delivery
- Inhibition of polyethylene glycol–induced histamine release by monomeric ethylene and diethylene glycol: A case of probable polyethylene glycol allergy
- (2012) Emily Cathrine Wenande et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The enhanced permeability retention effect: a new paradigm for drug targeting in infection
- (2012) E. A. Azzopardi et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Hypersensitivity to Polyethylene Glycols
- (2012) Sapna Shah et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Doxil® — The first FDA-approved nano-drug: Lessons learned
- (2012) Yechezkel (Chezy) Barenholz JOURNAL OF CONTROLLED RELEASE
- Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention
- (2011) Janos Szebeni et al. ADVANCED DRUG DELIVERY REVIEWS
- Macrogol hypersensitivity in multiple drug allergy
- (2011) Luisa Bommarito et al. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
- PEGylation of Proteins and Liposomes: a Powerful and Flexible Strategy to Improve the Drug Delivery
- (2011) Paola Milla et al. CURRENT DRUG METABOLISM
- A Novel PEGylated Interferon Beta-1a for Multiple Sclerosis: Safety, Pharmacology, and Biology
- (2011) Xiao Hu et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome
- (2011) János Szebeni et al. Nanomedicine-Nanotechnology Biology and Medicine
- FDA-approved poly(ethylene glycol)–protein conjugate drugs
- (2011) Steevens N. S. Alconcel et al. Polymer Chemistry
- Multimeric, Multifunctional Derivatives of Poly(ethylene glycol)
- (2011) Marina Zacchigna et al. Polymers
- Diffusion of Particles in the Extracellular Matrix: The Effect of Repulsive Electrostatic Interactions
- (2010) Triantafyllos Stylianopoulos et al. BIOPHYSICAL JOURNAL
- Development of aptamer therapeutics
- (2010) David HJ Bunka et al. CURRENT OPINION IN PHARMACOLOGY
- Curvature of Synthetic and Natural Surfaces Is an Important Target Feature in Classical Pathway Complement Activation
- (2010) Martin Bjerregård Pedersen et al. JOURNAL OF IMMUNOLOGY
- Anemia Control in Kidney Transplant Patients Treated With Methoxy Polyethylene Glycol-Epoetin Beta (Mircera): The Anemiatrans Group
- (2010) A. Sánchez-Fructuoso et al. TRANSPLANTATION PROCEEDINGS
- Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats
- (2010) Masako Ichihara et al. Pharmaceutics
- Prodrug Approaches for Enhancing the Bioavailability of Drugs with Low Solubility
- (2009) Christaâ E. Müller CHEMISTRY & BIODIVERSITY
- The role of the anaphylatoxins in health and disease
- (2009) Andreas Klos et al. MOLECULAR IMMUNOLOGY
- PEGylated PLGA nanoparticles for the improved delivery of doxorubicin
- (2009) Jason Park et al. Nanomedicine-Nanotechnology Biology and Medicine
- Understanding biophysicochemical interactions at the nano–bio interface
- (2009) Andre E. Nel et al. NATURE MATERIALS
- Usefulness of oral macrogol challenge in anaphylaxis after intra-articular injection of corticosteroid preparation
- (2008) C. Sohy et al. ALLERGY
- Phase III Trial of Gemcitabine Compared With Pegylated Liposomal Doxorubicin in Progressive or Recurrent Ovarian Cancer
- (2008) Gabriella Ferrandina et al. JOURNAL OF CLINICAL ONCOLOGY
- Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process
- (2008) I. Hamad et al. MOLECULAR IMMUNOLOGY
- Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
- (2008) Frank Alexis et al. MOLECULAR PHARMACEUTICS
- Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes
- (2007) Tatsuhiro Ishida et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
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