Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice

Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice

(2020) Nehal E. Elsadek et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon

(2020) Marwa Mohamed El Sayed et al.   JOURNAL OF CONTROLLED RELEASE

Pegfilgrastim (PEG-G-CSF) Induces Anti-polyethylene Glycol (PEG) IgM via a T Cell-Dependent Mechanism

(2020) Nehal E. Elsadek et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells

(2019) María Sancho-Albero et al.   JOURNAL OF NANOBIOTECHNOLOGY

Surface Engineering of Extracellular Vesicles through Chemical and Biological Strategies

(2019) Joseph J. Richardson et al.   CHEMISTRY OF MATERIALS

Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review

(2019) Kouichi Shiraishi et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention

(2019) Sixiang Shi et al.   BIOCONJUGATE CHEMISTRY

Generation, purification and engineering of extracellular vesicles and their biomedical applications

(2019) Jin Gao et al.   METHODS

Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues

(2019) Sherif E. Emam et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

T-Regulatory Cells In Tumor Progression And Therapy

(2019) Amit Verma et al.   Cancer Management and Research

A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research

(2018) Sherif E. Emam et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway

(2018) Bin Zhang et al.   CYTOTHERAPY

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

(2018) Golam Kibria et al.   MOLECULAR PHARMACEUTICS

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Pharmacokinetics of Exosomes—An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics

(2017) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

(2016) Thomas J. Povsic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells

(2015) Taro Shimizu et al.   IMMUNOBIOLOGY

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein

(2015) Yu Mima et al.   MOLECULAR PHARMACEUTICS

Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin

(2015) Giuseppe Toffoli et al.   Nanomedicine

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Anti-PEG immunity: emergence, characteristics, and unaddressed questions

(2015) Qi Yang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

New FDA Draft Guidance on Immunogenicity

(2014) Ashwin Parenky et al.   AAPS Journal

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

(2014) Michael S Hershfield et al.   ARTHRITIS RESEARCH & THERAPY

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

Questioning the use of PEGylation for drug delivery

(2013) Johan J. F. Verhoef et al.   Drug Delivery and Translational Research

Exosomes for targeted siRNA delivery across biological barriers

(2012) Samir EL Andaloussi et al.   ADVANCED DRUG DELIVERY REVIEWS

Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response

(2012) Taro Shimizu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Maintenance and break of immune tolerance against human factor VIII in a new transgenic hemophilic mouse model

(2011) P. M. van Helden et al.   BLOOD

307 HIGH PREVALENCE OF PRE-EXISTING ANTIBODIES AGAINST POLYETHYLENE GLYCOL (PEG) IN HEPATITIS C (HCV) PATIENTS WHICH IS NOT ASSOCIATED WITH IMPAIRED RESPONSE TO PEG-INTERFERON

(2010) H. Tillmann et al.   JOURNAL OF HEPATOLOGY