A Helicase Unwinds Hexanucleotide Repeat RNA G-Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation

SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase

(2020) Julie Martone et al.   EMBO REPORTS

E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands

(2020) Tapas Paul et al.   NUCLEIC ACIDS RESEARCH

Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension

(2020) Hui-Ting Lee et al.   BIOCHEMISTRY

Timeless couples G‐quadruplex detection with processing by DDX 11 helicase during DNA replication

(2020) Leticia K Lerner et al.   EMBO JOURNAL

G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA

(2020) Eric A J Simko et al.   NUCLEIC ACIDS RESEARCH

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

(2019) Sefan Asamitsu et al.   MOLECULES

Repeat-Associated Non-ATG Translation: Molecular Mechanisms and Contribution to Neurological Disease

(2019) Lien Nguyen et al.   Annual Review of Neuroscience

RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36

(2019) Ramreddy Tippana et al.   Nature Communications

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

(2019) Lindsey D. Goodman et al.   Acta Neuropathologica Communications

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats

(2019) Shizuka B. Yamada et al.   NATURE NEUROSCIENCE

DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

(2019) Markus Sauer et al.   Nature Communications

Catalytic Activities of Multimeric G-Quadruplex DNAzymes

(2019) Raphael I. Adeoye et al.   Catalysts

The role of RNA G‐quadruplexes in human diseases and therapeutic strategies

(2019) Prakash Kharel et al.   Wiley Interdisciplinary Reviews-RNA

HIV-1 Nucleocapsid Protein Unfolds Stable RNA G-Quadruplexes in the Viral Genome and Is Inhibited by G-Quadruplex Ligands

(2019) Elena Butovskaya et al.   ACS Infectious Diseases

CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation

(2019) Weiwei Cheng et al.   NEURON

Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome

(2018) Norifumi Shioda et al.   NATURE MEDICINE

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

(2018) Emanuela Ruggiero et al.   NUCLEIC ACIDS RESEARCH

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

(2018) Weiwei Cheng et al.   Nature Communications

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36

(2018) Michael C. Chen et al.   NATURE

RNAi-mediated knockdown of the Rhau helicase preferentially depletes proteins with a Guanine-quadruplex motif in the 5'-UTR of their mRNA

(2018) Karen Vester et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A C9orf72–CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress

(2018) Yang Liu et al.   GENES & DEVELOPMENT

Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions

(2017) Adam Ciesiolka et al.   Frontiers in Cellular Neuroscience

ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells

(2017) Marta M. Fay et al.   Cell Reports

Unraveling the Role of RNA Mediated Toxicity of C9orf72 Repeats in C9-FTD/ALS

(2017) Vijay Kumar et al.   Frontiers in Neuroscience

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches

(2016) David W. Dodd et al.   BIOCHEMISTRY

There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS

(2016) Aaron D. Gitler et al.   BRAIN RESEARCH

The multiple functions of RNA helicases as drivers and regulators of gene expression

(2016) Cyril F. Bourgeois et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA G-quadruplexes: emerging mechanisms in disease

(2016) Anne Cammas et al.   NUCLEIC ACIDS RESEARCH

Insight into G-quadruplex-hemin DNAzyme/RNAzyme: adjacent adenine as the intramolecular species for remarkable enhancement of enzymatic activity

(2016) Wang Li et al.   NUCLEIC ACIDS RESEARCH

Single-molecule imaging reveals a common mechanism shared by G-quadruplex–resolving helicases

(2016) Ramreddy Tippana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria

(2016) J. U. Guo et al.   SCIENCE

RNA G-quadruplex formation in defined sequence in living cells detected by bimolecular fluorescence complementation

(2016) Hong-he Liu et al.   Chemical Science

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

(2016) Erin G Conlon et al.   eLife

Metal Cations in G-Quadruplex Folding and Stability

(2016) Debmalya Bhattacharyya et al.   Frontiers in Chemistry

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

Characterization of DNA G-quadruplex species forming from C9ORF72 G4C2-expanded repeats associated with amyotrophic lateral sclerosis and frontotemporal lobar degeneration

(2015) Primož Šket et al.   NEUROBIOLOGY OF AGING

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex

(2015) Brahim Heddi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

(2014) Zhaoming Su et al.   NEURON

The Disease-associated r(GGGGCC)nRepeat from theC9orf72Gene Forms Tract Length-dependent Uni- and Multimolecular RNA G-quadruplex Structures

(2013) Kaalak Reddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Stability of RNA quadruplex in open reading frame determines proteolysis of human estrogen receptor α

(2013) Tamaki Endoh et al.   NUCLEIC ACIDS RESEARCH

DNA G-quadruplex formation in response to remote downstream transcription activity: long-range sensing and signal transducing in DNA double helix

(2013) C. Zhang et al.   NUCLEIC ACIDS RESEARCH

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

(2013) T. Zu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

(2013) C. Lagier-Tourenne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis of the frontotemporal lobar degeneration–amyotrophic lateral sclerosis spectrum

(2012) Tim van Langenhove et al.   ANNALS OF MEDICINE

The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

(2012) E. P. Booy et al.   NUCLEIC ACIDS RESEARCH

C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

(2012) Pietro Fratta et al.   Scientific Reports

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Repeat expansion disease: progress and puzzles in disease pathogenesis

(2010) Albert R. La Spada et al.   NATURE REVIEWS GENETICS

RNA mediated neurodegeneration in repeat expansion disorders

(2009) Peter K Todd et al.   ANNALS OF NEUROLOGY

Recruitment of the RNA Helicase RHAU to Stress Granules via a Unique RNA-binding Domain

(2008) Kateřina Chalupníková et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS