Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target

Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

(2010) Maxwell D. Cummings et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Creation and characterization of a cell-death reporter cell line for hepatitis C virus infection

(2010) Zhilei Chen et al.   ANTIVIRAL RESEARCH

Genome packaging in viruses

(2010) Siyang Sun et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system

(2010) Christopher T Jones et al.   NATURE BIOTECHNOLOGY

Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism

(2010) M. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures

(2010) A. Ploss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle

(2010) Karuppiah Chockalingam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathway of ATP utilization and duplex rRNA unwinding by the DEAD-box helicase, DbpA

(2010) A. Henn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

(2009) T.-I Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior

(2009) Ravi Rajagopalan et al.   BIOCHEMISTRY

Mechanistic Basis of 5′-3′ Translocation in SF1B Helicases

(2009) Kayarat Saikrishnan et al.   CELL

Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C

(2009) Craig A Belon et al.   Future Virology

The NS4A Protein of Hepatitis C Virus Promotes RNA-Coupled ATP Hydrolysis by the NS3 Helicase

(2009) R. K. F. Beran et al.   JOURNAL OF VIROLOGY

Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase

(2009) Qixin Wang et al.   NUCLEIC ACIDS RESEARCH

A chimeric mechanism for polyvalenttrans-phosphorylation of PKA by PDK1

(2009) Robert A. Romano et al.   PROTEIN SCIENCE

Translocation and Unwinding Mechanisms of RNA and DNA Helicases

(2008) Anna Marie Pyle   Annual Review of Biophysics

Monitoring helicase activity with molecular beacons

(2008) Craig A. Belon et al.   BIOTECHNIQUES

DNA binding to RecD: role of the 1B domain in SF1B helicase activity

(2008) Kayarat Saikrishnan et al.   EMBO JOURNAL

The emerging field of HCV drug resistance

(2008) Gennadiy Koev et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hepatitis C Virus NS3 Helicase Forms Oligomeric Structures That Exhibit Optimal DNA Unwinding Activityin Vitro

(2008) Bartek Sikora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NS3 Helicase from the Hepatitis C Virus Can Function as a Monomer or Oligomer Depending on Enzyme and Substrate Concentrations

(2008) Thomas A. Jennings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase

(2008) Rudolf K. F. Beran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase

(2008) Victor Serebrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

(2008) Michael D. Altman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

Non-hexameric DNA helicases and translocases: mechanisms and regulation

(2008) Timothy M. Lohman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors

(2008) Madhavi NL Nalam et al.   Current Opinion in HIV and AIDS

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

(2008) Nicole Appel et al.   PLoS Pathogens

Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

(2008) Timothy L. Tellinghuisen et al.   PLoS Pathogens

Single Strand Binding Proteins Increase the Processivity of DNA Unwinding by the Hepatitis C Virus Helicase

(2007) Vaishnavi Rajagopal et al.   JOURNAL OF MOLECULAR BIOLOGY