SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways

ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma

(2019) Zhenyu Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Expression patterns and the prognostic value of the SMYD family members in human breast carcinoma using integrative bioinformatics analysis

(2019) Jianping Song et al.   Oncology Letters

Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends

(2019) Edoardo Fabini et al.   Future Medicinal Chemistry

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3

(2019) Chuhui Huang et al.   ACS Medicinal Chemistry Letters

STAT3-induced SMYD3 transcription enhances chronic lymphocytic leukemia cell growth in vitro and in vivo

(2019) Fujia Lin et al.   INFLAMMATION RESEARCH

A Novel lncRNA IHS Promotes Tumor Proliferation and Metastasis in HCC by Regulating the ERK- and AKT/GSK-3β-Signaling Pathways

(2019) Zheng Chen et al.   Molecular Therapy-Nucleic Acids

Overexpression of the SMYD3 Promotes Proliferation, Migration, and Invasion of Pancreatic Cancer

(2019) Cheng-lin Zhu et al.   DIGESTIVE DISEASES AND SCIENCES

SMYD3 promotes implant metastasis of ovarian cancer via H3K4 trimethylation of integrin promoters

(2019) Tianjiao Lyu et al.   INTERNATIONAL JOURNAL OF CANCER

Lysine Methylation Regulators Moonlighting outside the Epigenome

(2019) Evan M. Cornett et al.   MOLECULAR CELL

The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network

(2019) Roberta Codato et al.   Scientific Reports

SMYD3 controls a Wnt-responsive epigenetic switch for ASCL2 activation and cancer stem cell maintenance

(2018) Tao Wang et al.   CANCER LETTERS

SMYD3 promoter hypomethylation is associated with the risk of colorectal cancer

(2018) Bin Li et al.   Future Oncology

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation

(2018) Michael J. Thomenius et al.   PLoS One

Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection

(2018) Hung-An Ting et al.   Mucosal Immunology

SMYD3 promotes the epithelial–mesenchymal transition in breast cancer

(2018) Claudio Fenizia et al.   NUCLEIC ACIDS RESEARCH

Smyd3-associated regulatory pathways in cancer

(2017) Antonis Giakountis et al.   SEMINARS IN CANCER BIOLOGY

MiR-346 suppresses cell proliferation through SMYD3 dependent approach in hepatocellular carcinoma

(2017) Weiyou Zhu et al.   Oncotarget

Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization

(2017) Yuichiro Yoshioka et al.   Cancer Medicine

Network analyses elucidate the role of SMYD3 in esophageal squamous cell carcinoma

(2017) Xinning Liu et al.   FEBS Open Bio

The long noncoding RNA SPRIGHTLY acts as an intranuclear organizing hub for pre-mRNA molecules

(2017) Bongyong Lee et al.   Science Advances

ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells

(2017) Lei Wang et al.   Journal of Gastric Cancer

Smyd3 open & closed lock mechanism for substrate recruitment: The hinge motion of C-terminal domain inferred from μ-second molecular dynamics simulations

(2016) Balasubramanian Chandramouli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development

(2016) Michalis E. Sarris et al.   CANCER CELL

SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation

(2016) C.-H. Tsai et al.   CANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Therapeutical potential of deregulated lysine methyltransferase SMYD3 as a safe target for novel anticancer agents

(2016) Gurukumari Rajajeyabalachandran et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

SMYD3 stimulates EZR and LOXL2 transcription to enhance proliferation, migration, and invasion in esophageal squamous cell carcinoma

(2016) Ying Zhu et al.   HUMAN PATHOLOGY

Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase

(2016) Weiqi Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Dynamics of Lysine Methyltransferase Smyd2. Insights into the Different Substrate Crevice Characteristics of Smyd2 and Smyd3

(2016) Balasubramanian Chandramouli et al.   Journal of Chemical Information and Modeling

Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets

(2016) Glenn S. Van Aller et al.   STRUCTURE

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

(2016) Yuichiro Yoshioka et al.   Oncotarget

RIZ1: a potential tumor suppressor in glioma

(2015) Chenran Zhang et al.   BMC CANCER

Histone methyltransferase SMYD3 regulates the expression of transcriptional factors during bovine oocyte maturation and early embryonic development

(2015) Haidong Bai et al.   CYTOTECHNOLOGY

A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth

(2015) Alessia Peserico et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection

(2015) D E de Almeida Nagata et al.   Mucosal Immunology

Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells

(2015) Jin-Man Kim et al.   NUCLEIC ACIDS RESEARCH

SET and MYND domain-containing protein 3 is overexpressed in human glioma and contributes to tumorigenicity

(2015) BIN DAI et al.   ONCOLOGY REPORTS

Overexpression of SMYD3 and matrix metalloproteinase-9 are associated with poor prognosis of patients with gastric cancer

(2015) Yong Liu et al.   TUMOR BIOLOGY

Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor

(2015) Lorna H. Mitchell et al.   ACS Medicinal Chemistry Letters

SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3

(2015) Filipa Quintela Vieira et al.   Oncotarget

C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis

(2015) Mark A. Brown et al.   Oncotarget

Genetic alterations of histone lysine methyltransferases and their significance in breast cancer

(2015) Lanxin Liu et al.   Oncotarget

SMYD Proteins: Key Regulators in Skeletal and Cardiac Muscle Development and Function

(2014) Shao Jun Du et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

(2014) Pawel K. Mazur et al.   NATURE

Effect of the downregulation of SMYD3 expression by RNAi on RIZ1 expression and proliferation of esophageal squamous cell carcinoma

(2014) SHANG-WEN DONG et al.   ONCOLOGY REPORTS

Interplay between the Cancer Genome and Epigenome

(2013) Hui Shen et al.   CELL

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

(2013) V. Proserpio et al.   GENES & DEVELOPMENT

SMYD3 as an Oncogenic Driver in Prostate Cancer by Stimulation of Androgen Receptor Transcription

(2013) Cheng Liu et al.   JNCI-Journal of the National Cancer Institute

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

(2012) Glenn S. Van Aller et al.   Epigenetics

Epigenetic regulation of miR-124 by Hepatitis C Virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3

(2012) Bing Zeng et al.   FEBS LETTERS

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

Intronic RNAs mediate EZH2 regulation of epigenetic targets

(2012) Sònia Guil et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Knockdown of SMYD3 by RNA interference inhibits cervical carcinoma cell growth and invasion in vitro

(2011) Shu-zhen Wang et al.   BMB Reports

SMYD3 Promotes Cancer Invasion by Epigenetic Upregulation of the Metalloproteinase MMP-9

(2011) A. M. Cock-Rada et al.   CANCER RESEARCH

The Histone Modifications GoverningTFF1Transcription Mediated by Estrogen Receptor

(2011) Yanyan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding

(2011) Shutong Xu et al.   NUCLEIC ACIDS RESEARCH

Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3

(2011) Kenneth W. Foreman et al.   PLoS One

Smyd3 Is Required for the Development of Cardiac and Skeletal Muscle in Zebrafish

(2011) Tomoaki Fujii et al.   PLoS One

The Language of Histone Crosstalk

(2010) Jung-Shin Lee et al.   CELL

Structural Insights into the Autoinhibition and Posttranslational Activation of Histone Methyltransferase SmyD3

(2010) Nualpun Sirinupong et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of SMYD3 over-expression on cell cycle acceleration and cell proliferation in MDA-MB-231 human breast cancer cells

(2010) Tian-nian Ren et al.   MEDICAL ONCOLOGY

Knockdown of SMYD3 by RNA interference down-regulates c-Met expression and inhibits cells migration and invasion induced by HGF

(2009) Jia-Ning Zou et al.   CANCER LETTERS

Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway

(2009) Liang Peng et al.   CARCINOGENESIS

Requirement of Histone Methyltransferase SMYD3 for Estrogen Receptor-mediated Transcription

(2009) Hyunjung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking

(2008) Haijian Wang et al.   CANCER SCIENCE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

The emerging field of dynamic lysine methylation of non-histone proteins

(2008) Jing Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT