SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation

Succinylation Links Metabolism to Protein Functions

(2019) Yun Yang et al.   NEUROCHEMICAL RESEARCH

Control of antiviral innate immune response by protein geranylgeranylation

(2019) Shigao Yang et al.   Science Advances

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

(2019) Xiang He et al.   EMBO JOURNAL

The dawn of succinylation: a posttranslational modification

(2018) Matthew Alleyn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

(2018) Luca Peruzzotti-Jametti et al.   Cell Stem Cell

Regulation of MAVS activation through post-translational modifications

(2018) Bingyu Liu et al.   CURRENT OPINION IN IMMUNOLOGY

Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis

(2018) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

(2018) Junjie Zhang et al.   Cell Host & Microbe

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection

(2018) Tong Dai et al.   Cell Host & Microbe

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

(2018) Tianliang Li et al.   Cell Host & Microbe

Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections

(2018) Tytti Heinonen et al.   Frontiers in Immunology

Demethylase Kdm6a epigenetically promotes IL-6 and IFN-β production in macrophages

(2017) Xia Li et al.   JOURNAL OF AUTOIMMUNITY

NAD + dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65

(2017) Kewei Qin et al.   JOURNAL OF AUTOIMMUNITY

Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain

(2017) Yuxun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

(2017) Fang Wang et al.   Cell Reports

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner

(2017) Run Fang et al.   PLoS Pathogens

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I

(2016) S. J. Choi et al.   EMBO JOURNAL

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Zebrafishfoxo3bNegatively Regulates Antiviral Response through Suppressing the Transactivity ofirf3andirf7

(2016) Xing Liu et al.   JOURNAL OF IMMUNOLOGY

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

(2016) Bingyu Liu et al.   NATURE IMMUNOLOGY

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production

(2015) Shanping He et al.   MOLECULAR CELL

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Response of host inflammasomes to viral infection

(2015) I-Yin Chen et al.   TRENDS IN MICROBIOLOGY

The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling

(2015) Young-Suk Yoo et al.   Nature Communications

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

SnapShot: Mammalian Sirtuins

(2014) Kristin A. Anderson et al.   CELL

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

(2014) Gregory R. Wagner et al.   MOLECULAR CELL

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

(2014) Hui Xu et al.   eLife

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

(2009) Fuping You et al.   NATURE IMMUNOLOGY

Regulation of Mitochondrial Antiviral Signaling Pathways

(2008) Chris B. Moore et al.   IMMUNITY

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY