Role of Intestinal Microbes in Chronic Liver Diseases

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

(2022) Martin Guilliams et al.   CELL

Gut microbiota dysbiosis in patients with hepatitis B virus-related cirrhosis

(2022) Wu Shu et al.   Annals of Hepatology

High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome

(2022) Wenshan Zheng et al.   SCIENCE

Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

(2022) Francesco Violi et al.   Nature Reviews Cardiology

High-content imaging of human hepatic spheroids for researching the mechanism of duloxetine-induced hepatotoxicity

(2022) Juan Liu et al.   Cell Death & Disease

Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis

(2022) Virginie Millet et al.   GUT

Diet, microbiota, and the mucus layer: The guardians of our health

(2022) Francesco Suriano et al.   Frontiers in Immunology

Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance

(2021) Lingjian Kong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

(2021) Shireen Mohammad et al.   Frontiers in Immunology

Guild-based analysis for understanding gut microbiome in human health and diseases

(2021) Guojun Wu et al.   Genome Medicine

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Butyrate and the Fine-Tuning of Colonic Homeostasis: Implication for Inflammatory Bowel Diseases

(2021) Naschla Gasaly et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depletion of Gut Microbiota Impairs Gut Barrier Function and Antiviral Immune Defense in the Liver

(2021) Weina Guo et al.   Frontiers in Immunology

The Role of the Microbiome in Liver Cancer

(2021) Mar Moreno-Gonzalez et al.   Cancers

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

(2021) Frank Tacke et al.   Annals of Translational Medicine

Examining the gut-liver axis in liver cancer using organoid models

(2021) Dmitrii Shek et al.   CANCER LETTERS

Hepatocellular Carcinoma Immunotherapy and the Potential Influence of Gut Microbiome

(2021) Sally Temraz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring tissue architecture using spatial transcriptomics

(2021) Anjali Rao et al.   NATURE

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis

(2021) T. Lohoff et al.   NATURE BIOTECHNOLOGY

Mass spectrometry-based metabolomics in microbiome investigations

(2021) Anelize Bauermeister et al.   NATURE REVIEWS MICROBIOLOGY

Gut microbiome-host interactions in driving environmental pollutant trichloroethene-mediated autoimmunity

(2021) Hui Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Probiotics-Based Treatment as an Integral Approach for Alcohol Use Disorder in Alcoholic Liver Disease

(2021) Catalina Fuenzalida et al.   Frontiers in Pharmacology

Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease

(2021) Pooja S. Salvi et al.   Cells

Lactic Acid Bacteria Exert a Hepatoprotective Effect against Ethanol-Induced Liver Injury in HepG2 Cells

(2021) Ji Yeon Lee et al.   Microorganisms

Gut microbiome and metabolic response in non-alcoholic fatty liver disease

(2021) Asmita Madatali Abuwani et al.   CLINICA CHIMICA ACTA

Changes in the gut microbiota after hepatitis C virus eradication

(2021) Takashi Honda et al.   Scientific Reports

Fecal Microbiota Transplantation Controls Progression of Experimental Autoimmune Hepatitis in Mice by Modulating the TFR/TFH Immune Imbalance and Intestinal Microbiota Composition

(2021) Ma Liang et al.   Frontiers in Immunology

Comprehensive analysis of spatial architecture in primary liver cancer

(2021) Rui Wu et al.   Science Advances

The gut microbiota instructs the hepatic endothelial cell transcriptome

(2021) Henning Formes et al.   iScience

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

(2020) Jens Walter et al.   CELL

Causes of mortality in Non-Alcoholic Fatty Liver Disease (NAFLD) and Alcohol related Fatty Liver Disease (AFLD).

(2020) Michael P Johnston et al.   CURRENT PHARMACEUTICAL DESIGN

Synbiotic Alters Fecal Microbiomes, but not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Non-alcoholic Fatty Liver Disease

(2020) Eleonora Scorletti et al.   GASTROENTEROLOGY

Functional circuits and signal processing in the enteric nervous system

(2020) Candice Fung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?

(2020) Fabien Magne et al.   Nutrients

What Is Metagenomics Teaching Us, and What Is Missed?

(2020) Felicia N. New et al.   Annual Review of Microbiology

Microbiomics, metabolomics, predicted metagenomics and hepatic steatosis in a population‐based study of 1355 adults

(2020) Louise JM Alferink et al.   HEPATOLOGY

Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH

(2020) Gianluca Svegliati-Baroni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology

(2020) Antonio Saviano et al.   JOURNAL OF HEPATOLOGY

Role of Microbiota in Pathogenesis and Management of Viral Hepatitis

(2020) Rashi Sehgal et al.   Frontiers in Cellular and Infection Microbiology

Fecal Microbiomes Distinguish Patients With Autoimmune Hepatitis From Healthy Individuals

(2020) Jiamin Lou et al.   Frontiers in Cellular and Infection Microbiology

Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients

(2020) Sonja Lang et al.   Gut Microbes

ALTERATIONS IN GUT MICROBIOME IN CIRRHOSIS AS ASSESSED BY QUANTITATIVE METAGENOMICS. RELATIONSHIP WITH ACUTE-ON-CHRONIC LIVER FAILURE AND PROGNOSIS

(2020) Cristina Solé et al.   GASTROENTEROLOGY

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

(2020) Laura Wrzosek et al.   GUT

Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism

(2020) Jin He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

(2020) Mikhail Nikolaev et al.   NATURE

Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-a-Chip System

(2020) Yaqing Wang et al.   ACS Biomaterials-Science & Engineering

Bifidobacterium animalis ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells

(2020) Hongxia Zhang et al.   Frontiers in Immunology

The gut microbiome-bile acid axis in hepatocarcinogenesis

(2020) Liwei Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Integrated analysis of microbiome and host transcriptome reveals correlations between gut microbiota and clinical outcomes in HBV-related hepatocellular carcinoma

(2020) Hechen Huang et al.   Genome Medicine

Effect of dietary carbohydrate and lipid modification on clinical and anthropometric parameters in nonalcoholic fatty liver disease: a systematic review and meta-analysis

(2020) Lais S Garcêz et al.   NUTRITION REVIEWS

Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature

(2019) Ivana Milosevic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alcohol, liver disease and the gut microbiota

(2019) Jasmohan S. Bajaj   Nature Reviews Gastroenterology & Hepatology

Role of intestinal microbiota and metabolites in inflammatory bowel disease

(2019) Li-Na Dong et al.   CHINESE MEDICAL JOURNAL

The pros, cons, and many unknowns of probiotics

(2019) Jotham Suez et al.   NATURE MEDICINE

Alterations of gut microbiome in autoimmune hepatitis

(2019) Yiran Wei et al.   GUT

Antibiotic pretreatment alleviates liver transplant damage in mice and humans

(2019) Kojiro Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

(2019) Mary Ellen Sanders et al.   Nature Reviews Gastroenterology & Hepatology

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Interplay of Human Gut Microbiome in Health and Wellness

(2019) Nirjara Singhvi et al.   INDIAN JOURNAL OF MICROBIOLOGY

Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity

(2019) Amelia T. Soderholm et al.   IMMUNOLOGY

The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease

(2019) Huikuan Chu et al.   JOURNAL OF HEPATOLOGY

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

Cellular and Molecular Mechanisms of Autoimmune Hepatitis

(2018) G.J. Webb et al.   Annual Review of Pathology-Mechanisms of Disease

Environmental factors, gut microbiota, and colorectal cancer prevention

(2018) Mingyang Song et al.   Clinical Gastroenterology and Hepatology

Gut Dysbiosis Associated With Hepatitis C Virus Infection

(2018) Takako Inoue et al.   CLINICAL INFECTIOUS DISEASES

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

(2018) Phillipp Hartmann et al.   HEPATOLOGY

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Preclinical models of non-alcoholic fatty liver disease

(2018) Prasanna K. Santhekadur et al.   JOURNAL OF HEPATOLOGY

Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury

(2018) Young-Eun Cho et al.   JOURNAL OF HEPATOLOGY

Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice

(2018) Shenhai Gong et al.   JOURNAL OF HEPATOLOGY

Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?

(2018) Chantal Villeneuve et al.   MICROBES AND INFECTION

The active microbial community more accurately reflects the anaerobic digestion process: 16S rRNA (gene) sequencing as a predictive tool

(2018) Jo De Vrieze et al.   Microbiome

Autoimmune hepatitis

(2018) Giorgina Mieli-Vergani et al.   Nature Reviews Disease Primers

Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

(2018) Huikuan Chu et al.   GUT

The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation

(2018) Kaisa Hiippala et al.   Nutrients

Influence of hepatitis C virus eradication with direct-acting antivirals on the gut microbiota in patients with cirrhosis

(2018) Francesca Romana Ponziani et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome

(2018) Alexander C. Ford et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Antimicrobial proteins: intestinal guards to protect against liver disease

(2018) Tim Hendrikx et al.   JOURNAL OF GASTROENTEROLOGY

Intestinal microbiota in patients with chronic hepatitis C with and without cirrhosis compared with healthy controls

(2017) Benjamin Heidrich et al.   LIVER INTERNATIONAL

Effect of Inulin on Proteome Changes Induced by Pathogenic Lipopolysaccharide in Human Colon

(2017) Michele Pier Luca Guarino et al.   PLoS One

Gut microbiota changes and chronic hepatitis C virus infection

(2017) Tomislav Preveden et al.   Expert Review of Gastroenterology & Hepatology

The Protective Role of Type I Interferons in the Gastrointestinal Tract

(2017) Kevin P. Kotredes et al.   Frontiers in Immunology

The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models

(2017) Miho Mizuno et al.   PLoS One

Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

(2017) Noora Ottman et al.   PLoS One

HCV eradication does not impact gut dysbiosis or systemic inflammation in cirrhotic patients

(2016) J. S. Bajaj et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Precision medicine in alcoholic and nonalcoholic fatty liver disease via modulating the gut microbiota

(2016) Sena Bluemel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach

(2016) Federica Del Chierico et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Profile of Gut Microbiota Associated With the Presence of Hepatocellular Cancer in Patients With Liver Cirrhosis

(2016) M. Grąt et al.   TRANSPLANTATION PROCEEDINGS

Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms

(2016) Fengyuan Li et al.   Gastroenterology Research and Practice

Alcoholic Liver Disease: A Mouse Model Reveals Protection by Lactobacillus fermentum

(2016) Rosario Barone et al.   Clinical and Translational Gastroenterology

Non-alcoholic fatty liver and the gut microbiota

(2016) Stavros Bashiardes et al.   Molecular Metabolism

Deep sequencing reveals microbiota dysbiosis of tongue coat in patients with liver carcinoma

(2016) Haifeng Lu et al.   Scientific Reports

Enterogenous bacterial glycolipids are required for the generation of natural killer T cells mediated liver injury

(2016) Yingfeng Wei et al.   Scientific Reports

Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease

(2015) M Llopis et al.   GUT

Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome

(2015) Yinfeng Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plasma metabolomic profiles enhance precision medicine for volunteers of normal health

(2015) Lining Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ethanol disrupts intestinal epithelial tight junction integrity through intracellular calcium-mediated Rho/ROCK activation

(2014) Elhaseen Elamin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

(2014) Sophie Leclercq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota in alcoholic liver disease: Pathogenetic role and therapeutic perspectives

(2014) Giulia Malaguarnera   WORLD JOURNAL OF GASTROENTEROLOGY

Natural killer T cells play a necessary role in modulating of immune-mediated liver injury by gut microbiota

(2014) Jianing Chen et al.   Scientific Reports

The protective effect of VSL#3 on intestinal permeability in a rat model of alcoholic intestinal injury

(2013) Bing Chang et al.   BMC GASTROENTEROLOGY

Abnormal fecal microbiota community and functions in patients with hepatitis B liver cirrhosis as revealed by a metagenomic approach

(2013) Xiao Wei et al.   BMC GASTROENTEROLOGY

Metabolites from intestinal microbes shape Treg

(2013) Markus B Geuking et al.   CELL RESEARCH

Lactobacillus GG-fermented milk prevents DSS-induced colitis and regulates intestinal epithelial homeostasis through activation of epidermal growth factor receptor

(2013) Kazutoyo Yoda et al.   EUROPEAN JOURNAL OF NUTRITION

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis

(2013) Lionel Rigottier-Gois   ISME Journal

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Colonic microbiome is altered in alcoholism

(2012) Ece A. Mutlu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Prevalence and Natural History of Alcoholic Liver Disease

(2012) Jonathan M. Schwartz et al.   Clinics in Liver Disease

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Effect of probiotic fermented milk and chlorophyllin on gene expressions and genotoxicity during AFB1-induced hepatocellular carcinoma

(2011) Manoj Kumar et al.   GENE

Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

(2010) Rachel C Anderson et al.   BMC MICROBIOLOGY

Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents

(2010) Le-Xing Yu et al.   HEPATOLOGY

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice

(2009) Arumugam Velayudham et al.   HEPATOLOGY

Pathogenesis of non-alcoholic fatty liver disease

(2009) J. K. Dowman et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates alcoholic liver disease in ethanol-containing diet-fed C57BL/6N mice

(2008) Shuichi Segawa et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Hepatitis B Virus Infection

(2008) Jules L. Dienstag   NEW ENGLAND JOURNAL OF MEDICINE