Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway

MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway

(2021) Shuhua Zhao et al.   Cell Death & Disease

Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway

(2021) Zhijing Ni et al.   Reproductive Biology and Endocrinology

Colorectal cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Underlying mechanisms of apoptosis in HepG2 cells induced by polyphyllin I through Fas death and mitochondrial pathways

(2020) Yawen Zeng et al.   TOXICOLOGY MECHANISMS AND METHODS

Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review

(2020) J. Arredondo et al.   Techniques in Coloproctology

Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway

(2020) Jianwen Long et al.   Biomed Research International

Detection of Total Reactive Oxygen Species in Adherent Cells by 2',7'-Dichlorodihydrofluorescein Diacetate Staining

(2020) Hyeoncheol Kim et al.   Jove-Journal of Visualized Experiments

The Landmark Series: Chemotherapy for Non-Metastatic Colon Cancer

(2020) Salvador Alonso et al.   ANNALS OF SURGICAL ONCOLOGY

PI3K/ Akt/ mTOR pathway as a therapeutic target for colorectal cancer: A review of preclinical and clinical evidence

(2019) Arunaksharan Narayanankutty   CURRENT DRUG TARGETS

Paris Polyphylla Inhibits Colorectal Cancer Cells via Inducing Autophagy and Enhancing the Efficacy of Chemotherapeutic Drug Doxorubicin

(2019) Liang-Tzung Lin et al.   MOLECULES

Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells

(2019) Junlin He et al.   BIOMEDICINE & PHARMACOTHERAPY

Polyphyllin I induces apoptosis and autophagy via modulating JNK and mTOR pathways in human acute myeloid leukemia cells

(2019) Ye Tian et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Adjuvant chemotherapy in resected colon cancer: When, how and how long?

(2019) Alain J. Gelibter et al.   SURGICAL ONCOLOGY-OXFORD

Polyphyllin I induces cell cycle arrest in prostate cancer cells via the upregulation of IL6 and P21 expression

(2019) Denglu Zhang et al.   MEDICINE

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

(2019) Dejiang Pang et al.   Oxidative Medicine and Cellular Longevity

Anti-cancer effects of Polyphyllin I: An update in 5 years

(2019) Ye Tian et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Polyphyllin I Induces Cell Cycle Arrest and Cell Apoptosis in Human Retinoblastoma Y-79 Cells through Targeting p53

(2018) Xue Zhu et al.   Anti-Cancer Agents in Medicinal Chemistry

NCCN Guidelines Insights: Colon Cancer, Version 2.2018

(2018) Al B. Benson et al.   Journal of the National Comprehensive Cancer Network

Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells

(2017) Kwang-Youn Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anticancer effect of Polyphyllin Ι in colorectal cancer cells through ROS-dependent autophagy and G2/M arrest mechanisms

(2017) Si Yu et al.   NATURAL PRODUCT RESEARCH

Autophagy protects against PI3K/Akt/mTOR-mediated apoptosis of spinal cord neurons after mechanical injury

(2017) ZhenYu Wang et al.   NEUROSCIENCE LETTERS

4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells

(2017) Peng Duan et al.   TOXICOLOGY LETTERS

Autophagic cell death induced by reactive oxygen species is involved in hyperthermic sensitization to ionizing radiation in human hepatocellular carcinoma cells

(2017) Guang-Jin Yuan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy activated by the c-Jun N-terminal kinase-mediated pathway protects human prostate cancer PC3 cells from celecoxib-induced apoptosis

(2017) Xin Zhu et al.   Experimental and Therapeutic Medicine

Mecambridine induces potent cytotoxic effects, autophagic cell death and modulation of the mTOR/PI3K/Akt signaling pathway in HSC‑3 oral squamous cell carcinoma cells

(2017) Na Lin et al.   Oncology Letters

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

(2017) Chunguang Yang et al.   Drug Design Development and Therapy

Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels

(2017) Guo-Bing Li et al.   Oncotarget

Tumor grade related expression of neuroglobin is negatively regulated by PPARγ and confers antioxidant activity in glioma progression

(2017) Jing Hu et al.   Redox Biology

Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells

(2016) Lili Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Polyphyllin I induces cell cycle arrest and apoptosis in human myeloma cells via modulatingβ-catenin signaling pathway

(2016) Yun Liang et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells

(2016) Chunhui Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells

(2016) Guowen Ren et al.   PHYTOMEDICINE

Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo

(2016) Jui-Chieh Chen et al.   Oncotarget

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

(2016) Chao Zhang et al.   PLoS One

NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7

(2015) Suhrid Banskota et al.   Molecular Cancer

Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells

(2015) Ya-Min Shi et al.   PHYTOMEDICINE

Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

(2014) P Makhov et al.   BRITISH JOURNAL OF CANCER

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

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(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting autophagic pathways for cancer drug discovery

(2012) Bo Liu et al.   Chinese Journal of Cancer

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

(2011) C. T. Shearn et al.   MOLECULAR PHARMACOLOGY

Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft

(2010) M. Kong et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

Colon cancer

(2010) Roberto Labianca et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Antifungal Saponins fromParis polyphyllaSmith

(2008) Dawei Deng et al.   PLANTA MEDICA