An integrative view on sex differences in brain tumors

Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy

(2016) Morris Waskar et al.   Aging-US

Novel Therapeutic Targets of Tumor Metabolism

(2015) Rigel J. Kishton et al.   CANCER JOURNAL

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

(2014) Joni Van der Meulen et al.   BLOOD

The Cyclic AMP Pathway Is a Sex-Specific Modifier of Glioma Risk in Type I Neurofibromatosis Patients

(2014) N. M. Warrington et al.   CANCER RESEARCH

The potential role of O-GlcNAc modification in cancer epigenetics

(2014) Ewa Forma et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The H3K27me3 demethylase UTX in normal development and disease

(2014) Joni Van der Meulen et al.   Epigenetics

Conceptual frameworks and mouse models for studying sex differences in physiology and disease: Why compensation changes the game

(2014) Arthur P. Arnold   EXPERIMENTAL NEUROLOGY

X-chromosome inactivation in development and cancer

(2014) Ronan Chaligné et al.   FEBS LETTERS

Human UTY(KDM6C) Is a Male-specificNϵ-Methyl Lysyl Demethylase

(2014) Louise J. Walport et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males

(2014) Tao Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

(2014) Lillian Cruz-Orengo et al.   JOURNAL OF CLINICAL INVESTIGATION

Placental Cytokine Expression Covaries with Maternal Asthma Severity and Fetal Sex

(2014) N. M. Scott et al.   JOURNAL OF IMMUNOLOGY

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

(2014) S. C. Mack et al.   NATURE

C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

(2014) Matthew Parker et al.   NATURE

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

(2014) Pawel Buczkowicz et al.   NATURE GENETICS

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

(2014) Xuelian He et al.   NATURE MEDICINE

X chromosome regulation: diverse patterns in development, tissues and disease

(2014) Xinxian Deng et al.   NATURE REVIEWS GENETICS

AMPK regulates histone H2B O-GlcNAcylation

(2014) Qiuran Xu et al.   NUCLEIC ACIDS RESEARCH

Sex Differences in the Developmental Origins of Cardiovascular Disease

(2014) Suttira Intapad et al.   PHYSIOLOGY

Androgen Deprivation Therapy for Prostate Cancer Is Associated with Cardiovascular Morbidity and Mortality: A Meta-Analysis of Population-Based Observational Studies

(2014) Jinsheng Zhao et al.   PLoS One

Sexual Dimorphism in the Early Embryogenesis in Zebra Finches

(2014) Makhsud Tagirov et al.   PLoS One

Gene Expression Analyses of the Spatio-Temporal Relationships of Human Medulloblastoma Subgroups during Early Human Neurogenesis

(2014) Cornelia M. Hooper et al.   PLoS One

Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation

(2014) Haydn T. Kissick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sexual Conflict, Life Span, and Aging

(2014) M. I. Adler et al.   Cold Spring Harbor Perspectives in Biology

Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease

(2013) Raouf A. Khalil   BIOCHEMICAL PHARMACOLOGY

Chromatin Remodeling Defects in Pediatric and Young Adult Glioblastoma: A Tale of a Variant Histone 3 Tail

(2013) Adam M. Fontebasso et al.   BRAIN PATHOLOGY

Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 inH3F3AK27M Mutant Glioblastomas

(2013) Sriram Venneti et al.   BRAIN PATHOLOGY

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

(2013) Sebastian Bender et al.   CANCER CELL

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

(2013) Eda Yildirim et al.   CELL

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

(2013) K.-M. Chan et al.   GENES & DEVELOPMENT

The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease

(2013) L. K. Case et al.   GENOME RESEARCH

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Microglia Are Essential to Masculinization of Brain and Behavior

(2013) K. M. Lenz et al.   JOURNAL OF NEUROSCIENCE

Microglia: Multiple roles in surveillance, circuit shaping, and response to injury

(2013) E. E. Benarroch   NEUROLOGY

Transitioning from genotypes to epigenotypes: Why the time has come for medulloblastoma epigenomics

(2013) N.V. Batora et al.   NEUROSCIENCE

O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development

(2013) C. L. Howerton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging association between androgen deprivation therapy and male meningioma: significant expression of luteinizing hormone-releasing hormone receptor in male meningioma

(2013) Q Li et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Does the clinical spectrum of incident cardiovascular disease differ between men and women?

(2013) Hanna-Riikka Lehto et al.   European Journal of Preventive Cardiology

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

Mitochondria, maternal inheritance, and asymmetric fitness: Why males die younger

(2012) Jonci N. Wolff et al.   BIOESSAYS

Mutations inLyarandp53are synergistically lethal in female mice

(2012) Guan Wang et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer treatment and survivorship statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

An Animal Model of MYC-Driven Medulloblastoma

(2012) Yanxin Pei et al.   CANCER CELL

Mitochondria, Maternal Inheritance, and Male Aging

(2012) M. Florencia Camus et al.   CURRENT BIOLOGY

Opposite effects of microchimerism on breast and colon cancer

(2012) Mads Kamper-Jørgensen et al.   EUROPEAN JOURNAL OF CANCER

Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes

(2012) J. T. Wolstenholme et al.   GENES BRAIN AND BEHAVIOR

Sex, glia, and development: Interactions in health and disease

(2012) Jaclyn M. Schwarz et al.   HORMONES AND BEHAVIOR

Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia

(2012) Batbayar Khulan et al.   HUMAN MOLECULAR GENETICS

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

Role of the systemic immune system in brain metastasis

(2012) Alastair Hamilton et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Therapeutic Significance of Estrogen Receptor   Agonists in Gliomas

(2012) G. R. Sareddy et al.   MOLECULAR CANCER THERAPEUTICS

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12

(2012) J. C. Amlin-Van Schaick et al.   NEURO-ONCOLOGY

Epidemiology of Meningioma in the United Kingdom

(2012) Lucía Cea-Soriano et al.   NEUROEPIDEMIOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Meningiomas in Pregnancy

(2012) Eriks A. Lusis et al.   NEUROSURGERY

Resource allocation in utero and health in later life

(2012) D.J.P. Barker et al.   PLACENTA

Increased Microglia/Macrophage Gene Expression in a Subset of Adult and Pediatric Astrocytomas

(2012) Jane R. Engler et al.   PLoS One

Maternal Diets Trigger Sex-Specific Divergent Trajectories of Gene Expression and Epigenetic Systems in Mouse Placenta

(2012) Anne Gabory et al.   PLoS One

Why does Jack, and not Jill, break his crown? Sex disparity in brain tumors

(2012) Tao Sun et al.   Biology of Sex Differences

Review: magnetic resonance imaging of male/female differences in human adolescent brain anatomy

(2012) Jay N Giedd et al.   Biology of Sex Differences

Symptomatic meningioma induced by cross-sex hormone treatment in a male-to-female transsexual

(2012) Marina T. Bergoglio et al.   Endocrinologia y Nutricion

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Expression of selected genes escaping from X inactivation in the 41, XXY* mouse model for Klinefelter’s syndrome

(2011) Steffi Werler et al.   ACTA PAEDIATRICA

Sex differences in telomeres and lifespan

(2011) Emma L. B. Barrett et al.   AGING CELL

The Coupling of X-Chromosome Inactivation to Pluripotency

(2011) Jane Lynda Deuve et al.   Annual Review of Cell and Developmental Biology

The increasing incidence and prevalence of female multiple sclerosis—A critical analysis of potential environmental factors

(2011) Johann Sellner et al.   AUTOIMMUNITY REVIEWS

Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

(2011) Hendrik Witt et al.   CANCER CELL

Hormonal therapies and meningioma: Is there a link?

(2011) Lucía Cea-Soriano et al.   Cancer Epidemiology

Sex Disparities in Cancer Mortality and Survival

(2011) M. B. Cook et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Chromosome silencing mechanisms in X-chromosome inactivation: unknown unknowns

(2011) N. Brockdorff   DEVELOPMENT

A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones

(2011) Henk Asscheman et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Mechanistic insights into chromosome-wide silencing in X inactivation

(2011) Susanne Arthold et al.   HUMAN GENETICS

The X chromosome and immune associated genes

(2011) Ilaria Bianchi et al.   JOURNAL OF AUTOIMMUNITY

Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction

(2011) Balázs Börzsönyi et al.   JOURNAL OF PERINATAL MEDICINE

Maternal folate supply and sex influence gene-specific DNA methylation in the fetal gut

(2011) Jill A. McKay et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation

(2011) Tim Kees et al.   NEURO-ONCOLOGY

The end of gonad-centric sex determination in mammals

(2011) Arthur P. Arnold   TRENDS IN GENETICS

Epidemiology of Brain Metastases

(2011) Lakshmi Nayak et al.   Current Oncology Reports

Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide

(2011) María Santos-Galindo et al.   Biology of Sex Differences

Regression of meningiomas after discontinuation of cyproterone acetate in a transsexual patient

(2010) Helene Cebula et al.   ACTA NEUROCHIRURGICA

Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11β-hydroxysteroid dehydrogenase type 2 in a sex-specific manner

(2010) Mariana Baserga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Exogenous sex hormone use and risk of meningioma: a population-based case–control study in Finland

(2010) K. Korhonen et al.   CANCER CAUSES & CONTROL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Cyclic AMP Suppression Is Sufficient to Induce Gliomagenesis in a Mouse Model of Neurofibromatosis-1

(2010) N. M. Warrington et al.   CANCER RESEARCH

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

The Unexplained Female Predominance of Systemic Lupus Erythematosus: Clues from Genetic and Cytokine Studies

(2010) Corinna E. Weckerle et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Protective role of 17β-estradiol on medulloblastoma development in Patched1 heterozygous mice

(2010) Mariateresa Mancuso et al.   INTERNATIONAL JOURNAL OF CANCER

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Meningioma in pregnancy

(2010) S. Patel et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Subtypes of medulloblastoma have distinct developmental origins

(2010) Paul Gibson et al.   NATURE

Cross-species genomics matches driver mutations and cell compartments to model ependymoma

(2010) Robert A. Johnson et al.   NATURE

Fetal microchimerism as an explanation of disease

(2010) Laura Fugazzola et al.   Nature Reviews Endocrinology

Sex determines the expression level of one third of the actively expressed genes in bovine blastocysts

(2010) P. Bermejo-Alvarez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria as regulatory forces in oocytes, preimplantation embryos and stem cells

(2010) Jonathan Van Blerkom   REPRODUCTIVE BIOMEDICINE ONLINE

Fetal Microchimeric Cells Participate in Tumour Angiogenesis in Melanomas Occurring during Pregnancy

(2009) Sau Nguyen Huu et al.   AMERICAN JOURNAL OF PATHOLOGY

Sex differences in rheumatoid arthritis: more than meets the eye...

(2009) Ronald F van Vollenhoven   BMC Medicine

Brain metastases admissions in Sweden between 1987 and 2006

(2009) K E Smedby et al.   BRITISH JOURNAL OF CANCER

Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma

(2009) Tracy-Ann Read et al.   CANCER CELL

TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility

(2009) Thuy N. Do et al.   CANCER GENETICS AND CYTOGENETICS

Association of MDM2 SNP309, Age of Onset, and Gender in Cutaneous Melanoma

(2009) E. F. Firoz et al.   CLINICAL CANCER RESEARCH

SEX DIFFERENCES, SEXUAL SELECTION, AND AGEING: AN EXPERIMENTAL EVOLUTION APPROACH

(2009) Alexei A. Maklakov et al.   EVOLUTION

Blockade of estrogen receptor signaling to improve outlook for medulloblastoma sufferers

(2009) Scott M Belcher   Future Oncology

Angiogenesis and expression of estrogen and progesterone receptors as predictive factors for recurrence of meningioma

(2009) Patricia Guevara et al.   JOURNAL OF NEURO-ONCOLOGY

Chr 19A/J modifies tumor resistance in a sex- and parent-of-origin-specific manner

(2009) Jessica C. Walrath et al.   MAMMALIAN GENOME

Cerebellum development during childhood and adolescence: A longitudinal morphometric MRI study

(2009) Henning Tiemeier et al.   NEUROIMAGE

Neonates Born to Mothers With Preeclampsia Exhibit Sex-Specific Alterations in Microvascular Function

(2009) Michael J Stark et al.   PEDIATRIC RESEARCH

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere dynamics rather than age predict life expectancy in the wild

(2009) P. Bize et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL

Targeted Inhibition of Cyclic AMP Phosphodiesterase-4 Promotes Brain Tumor Regression

(2008) P. Goldhoff et al.   CLINICAL CANCER RESEARCH

Prognostic Significance of Epithelial-Mesenchymal and Mesenchymal-Epithelial Transition Protein Expression in Non-Small Cell Lung Cancer

(2008) A. Soltermann et al.   CLINICAL CANCER RESEARCH

Meningioma

(2008) Christine Marosi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues?

(2008) Arthur P. Arnold et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Increased fetal cell microchimerism in high grade breast carcinomas occurring during pregnancy

(2008) Gil Dubernard et al.   INTERNATIONAL JOURNAL OF CANCER

Is There an Association Between Meningioma and Hormone Replacement Therapy?

(2008) Svetlana Blitshteyn et al.   JOURNAL OF CLINICAL ONCOLOGY

Sex-specific genetic architecture of human disease

(2008) Carole Ober et al.   NATURE REVIEWS GENETICS

Gender affects survival for medulloblastoma only in older children and adults: A study from the surveillance epidemiology and end results registry

(2008) Emily K. Curran et al.   PEDIATRIC BLOOD & CANCER

Estradiol and the Developing Brain

(2008) MARGARET M. McCARTHY   PHYSIOLOGICAL REVIEWS

Sex difference in neural tube defects inp53-null mice is caused by differences in the complement of X not Y genes

(2007) Xuqi Chen et al.   Developmental Neurobiology

GPR30 Contributes to Estrogen-Induced Thymic Atrophy

(2007) Chunhe Wang et al.   MOLECULAR ENDOCRINOLOGY

Epigenetic differences between male and female bovine blastocysts produced in vitro

(2007) P. Bermejo-Álvarez et al.   PHYSIOLOGICAL GENOMICS

The effect of glucosamine concentration on the development and sex ratio of bovine embryos

(2006) Koji Kimura et al.   ANIMAL REPRODUCTION SCIENCE