P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals

The role of STIM and ORAI proteins in phagocytic immune cells

(2016) Nicolas Demaurex et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

(2016) K. Martinod et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Gout

(2016) Nicola Dalbeth et al.   LANCET

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Pharmacology and structure of P2Y receptors

(2016) Ivar von Kügelgen et al.   NEUROPHARMACOLOGY

2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2015) Tuhina Neogi et al.   ANNALS OF THE RHEUMATIC DISEASES

Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells

(2015) Elizandra Braganhol et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

(2015) Jyaysi Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways

(2015) KAZUNARI IBUSUKI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Store-operated calcium signaling in neutrophils

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At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

(2015) Peter C. Grayson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Global epidemiology of gout: prevalence, incidence and risk factors

(2015) Chang-Fu Kuo et al.   Nature Reviews Rheumatology

ATP release through pannexon channels

(2015) Gerhard Dahl   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Study for Updated Gout Classification Criteria: Identification of Features to Classify Gout

(2015) William J. Taylor et al.   ARTHRITIS CARE & RESEARCH

The Gouty Tophus: a Review

(2015) Ashika Chhana et al.   Current Rheumatology Reports

fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils

(2015) María A. Hidalgo et al.   Journal of Immunology Research

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

(2014) Jon Hazeldine et al.   AGING CELL

Regulation of immune responses by neutrophils

(2014) Jing Wang et al.   Annals of the New York Academy of Sciences

Imaging modalities for the classification of gout: systematic literature review and meta-analysis

(2014) Alexis Ogdie et al.   ANNALS OF THE RHEUMATIC DISEASES

STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense

(2014) H. Zhang et al.   BLOOD

A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide

(2014) Karin Önnheim et al.   EXPERIMENTAL CELL RESEARCH

STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia

(2014) Marlen Michaelis et al.   GLIA

Inhibition of UDP/P2Y6purinergic signaling prevents phagocytosis of viable neurons by activated microgliain vitroandin vivo

(2014) Jonas J. Neher et al.   GLIA

NET formation induced by Pseudomonas aeruginosa cystic fibrosis isolates measured as release of myeloperoxidase–DNA and neutrophil elastase–DNA complexes

(2014) Dae-goon Yoo et al.   IMMUNOLOGY LETTERS

P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells

(2014) H. Campwala et al.   JOURNAL OF CELL SCIENCE

Intestinal Inflammation Increases the Expression of the P2Y6 Receptor on Epithelial Cells and the Release of CXC Chemokine Ligand 8 by UDP

(2014) D. M. Grbic et al.   JOURNAL OF IMMUNOLOGY

Release of Cystic Fibrosis Airway Inflammatory Markers from Pseudomonas aeruginosa-Stimulated Human Neutrophils Involves NADPH Oxidase-Dependent Extracellular DNA Trap Formation

(2014) D.-g. Yoo et al.   JOURNAL OF IMMUNOLOGY

Extracellular UDP and P2Y6Function as a Danger Signal To Protect Mice from Vesicular Stomatitis Virus Infection through an Increase in IFN-β Production

(2014) Ruimei Li et al.   JOURNAL OF IMMUNOLOGY

Purine receptor P2Y6 mediates cellular response to ^|^gamma;-ray-induced DNA damage

(2014) Shunta Ide et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice

(2014) Katharina Martina Janice Syhr et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Efficient Neutrophil Extracellular Trap Induction Requires Mobilization of Both Intracellular and Extracellular Calcium Pools and Is Modulated by Cyclosporine A

(2014) Anurag Kumar Gupta et al.   PLoS One

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

The Role of Nucleotides and Purinergic Signaling in Apoptotic Cell Clearance – Implications for Chronic Inflammatory Diseases

(2014) Jin Chen et al.   Frontiers in Immunology

The Neutrophil in Chronic Obstructive Pulmonary Disease. Too Little, Too Late or Too Much, Too Soon?

(2013) Kim Hoenderdos et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Staphylococcus aureus Leukotoxin ED Targets the Chemokine Receptors CXCR1 and CXCR2 to Kill Leukocytes and Promote Infection

(2013) Tamara Reyes-Robles et al.   Cell Host & Microbe

Aggrecanases in the human synovial fluid at different stages of osteoarthritis

(2013) Enshui Zhang et al.   CLINICAL RHEUMATOLOGY

Neutrophil Elastase-Mediated Lung Disease

(2013) Robert A. Sandhaus et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Quantitative evaluation of CXCL8 and its receptors (CXCR1 and CXCR2) gene expression in Iranian patients with multiple sclerosis

(2013) Shohreh Almasi et al.   IMMUNOLOGICAL INVESTIGATIONS

Pseudogout-Associated Inflammatory Calcium Pyrophosphate Dihydrate Microcrystals Induce Formation of Neutrophil Extracellular Traps

(2013) L. Pang et al.   JOURNAL OF IMMUNOLOGY

Optimization of N-Benzoylindazole Derivatives as Inhibitors of Human Neutrophil Elastase

(2013) Letizia Crocetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lack of specificity shown by P2Y6 receptor antibodies

(2013) Weiqun Yu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyocyanin-Enhanced Neutrophil Extracellular Trap Formation Requires the NADPH Oxidase

(2013) Balázs Rada et al.   PLoS One

The P2Y6 Receptor Mediates Clostridium difficile Toxin-Induced CXCL8/IL-8 Production and Intestinal Epithelial Barrier Dysfunction

(2013) Ashleigh Hansen et al.   PLoS One

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

(2013) Fenila Jacob et al.   Purinergic Signalling

Neutrophils, IL-1β, and gout: is there a link?

(2013) Ioannis Mitroulis et al.   Seminars in Immunopathology

How to regulate neutrophils in gout

(2013) Alexander So   ARTHRITIS RESEARCH & THERAPY

UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety

(2012) Tamar Ginsburg-Shmuel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

CCR5 is a receptor for Staphylococcus aureus leukotoxin ED

(2012) Francis Alonzo III et al.   NATURE

Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition

(2012) Ravi S. Keshari et al.   PLoS One

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells

(2012) Christine Schorn et al.   Frontiers in Immunology

Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest

(2012) Neha Dixit et al.   Frontiers in Immunology

P2Y6 Receptor Contributes to Neutrophil Recruitment to Inflamed Intestinal Mucosa by Increasing Cxc Chemokine Ligand 8 Expression in an AP-1-dependent Manner in Epithelial Cells

(2011) Djordje M. Grbic et al.   INFLAMMATORY BOWEL DISEASES

P2Y6 Receptor Signaling Pathway Mediates Inflammatory Responses Induced by Monosodium Urate Crystals

(2011) H. Uratsuji et al.   JOURNAL OF IMMUNOLOGY

P2Y6 Agonist Uridine 5'-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/Macrophages Recruitment

(2011) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum

(2011) Maria Grazia Zizzo et al.   Purinergic Signalling

Gout. Epidemiology of gout

(2011) Edward Roddy et al.   ARTHRITIS RESEARCH & THERAPY

Store-Operated Calcium Channels: New Perspectives on Mechanism and Function

(2011) R. S. Lewis   Cold Spring Harbor Perspectives in Biology

Coronary Infarction and Gout.

(2010) ERIK ASK-UPMARK et al.   ACTA MEDICA SCANDINAVICA

Evaluation of the effect of α-defensin human neutrophil peptides on neutrophil apoptosis

(2010) Nagaoka   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Gout—bad for the heart as well as the joint

(2010) Alexander So   Nature Reviews Rheumatology

Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

(2010) Y. Chen et al.   Science Signaling

Mechanisms of inflammation in gout

(2010) Nathalie Busso et al.   ARTHRITIS RESEARCH & THERAPY

Purinergic Control of Neutrophil Activation

(2010) F. Grassi   Journal of Molecular Cell Biology

A magic bullet for gout?

(2009) A. So et al.   ANNALS OF THE RHEUMATIC DISEASES

Crystal-induced neutrophil activation

(2009) Oana Popa-Nita et al.   IMMUNOLOGY AND CELL BIOLOGY

P2Y6 receptor and immunoinflammation

(2009) Gui-Dong Liu et al.   Neuroscience Bulletin

Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists

(2008) Hyojin Ko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Developments in the scientific and clinical understanding of gout

(2008) Alexander So   ARTHRITIS RESEARCH & THERAPY

A modified Delphi exercise to determine the extent of consensus with OMERACT outcome domains for studies of acute and chronic gout

(2007) W J Taylor et al.   ANNALS OF THE RHEUMATIC DISEASES