Regulation of immune responses by neutrophils

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells

(2013) H. Matsushima et al.   BLOOD

Emergence, origin, and function of neutrophil-dendritic cell hybrids in experimentally induced inflammatory lesions in mice

(2013) S. Geng et al.   BLOOD

Hypoxia-inducible factor 2  regulates key neutrophil functions in humans, mice, and zebrafish

(2013) A. A. R. Thompson et al.   BLOOD

Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo

(2013) B. G. Yipp et al.   BLOOD

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staphylococcus aureus Degrades Neutrophil Extracellular Traps to Promote Immune Cell Death

(2013) V. Thammavongsa et al.   SCIENCE

Neutrophils in innate and adaptive immunity

(2013) Sébastien Jaillon et al.   Seminars in Immunopathology

Getting Leukocytes to the Site of Inflammation

(2013) W. A. Muller   VETERINARY PATHOLOGY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Reactive Oxygen Species and Antioxidants in Pulmonary Hypertension

(2012) Chi-Ming Wong et al.   ANTIOXIDANTS & REDOX SIGNALING

VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

(2012) G. Christoffersson et al.   BLOOD

Ly6G ligation blocks recruitment of neutrophils via a  2-integrin-dependent mechanism

(2012) J.-X. Wang et al.   BLOOD

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice

(2012) Yvonne Döring et al.   CIRCULATION RESEARCH

Multiple Roles for Neutrophils in Atherosclerosis

(2012) Oliver Soehnlein   CIRCULATION RESEARCH

Intravital 2-photon imaging of leukocyte trafficking in beating heart

(2012) Wenjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-Specific Neutrophil Recruitment into the Lung, Liver, and Kidney

(2012) Jan Rossaint et al.   Journal of Innate Immunity

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil rolling at high shear: Flattening, catch bond behavior, tethers and slings

(2012) Prithu Sundd et al.   MOLECULAR IMMUNOLOGY

The molecular basis of leukocyte recruitment and its deficiencies

(2012) Sarah Schmidt et al.   MOLECULAR IMMUNOLOGY

‘Slings’ enable neutrophil rolling at high shear

(2012) Prithu Sundd et al.   NATURE

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

(2012) Jing Wang et al.   NATURE IMMUNOLOGY

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

(2012) Mehmet A Eskan et al.   NATURE IMMUNOLOGY

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus

(2012) Sapna Devi et al.   NATURE MEDICINE

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Increased Intratumoral Neutrophil in Colorectal Carcinomas Correlates Closely with Malignant Phenotype and Predicts Patients' Adverse Prognosis

(2012) Hui-Lan Rao et al.   PLoS One

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity

(2012) M. Beyrau et al.   Open Biology

Genetic Defects in Severe Congenital Neutropenia: Emerging Insights into Life and Death of Human Neutrophil Granulocytes

(2011) Christoph Klein   Annual Review of Immunology

Deuterium and neutrophil kinetics

(2011) K. W. Li et al.   BLOOD

Doubts concerning the recently reported human neutrophil lifespan of 5.4 days

(2011) P. S. Tofts et al.   BLOOD

Neutrophil survival and c-kit+-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution

(2011) M.-H. Kim et al.   BLOOD

Reconstruction of integrin activation

(2011) F. Ye et al.   BLOOD

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

(2011) A. D. Gregory et al.   CANCER RESEARCH

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Failure to detect production of IL-10 by activated human neutrophils

(2011) Martin S Davey et al.   NATURE IMMUNOLOGY

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

(2011) Tibor Kempf et al.   NATURE MEDICINE

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Neutrophils and Intravascular Immunity in the Liver during Infection and Sterile Inflammation

(2011) Braedon McDonald et al.   TOXICOLOGIC PATHOLOGY

Neutrophils in tuberculosis: friend or foe?

(2011) David M. Lowe et al.   TRENDS IN IMMUNOLOGY

Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE−/− Mice

(2010) Pierre Rotzius et al.   AMERICAN JOURNAL OF PATHOLOGY

High Neutrophil Numbers in Human Carotid Atherosclerotic Plaques Are Associated With Characteristics of Rupture-Prone Lesions

(2010) Mihaela G. Ionita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophils in a mouse model of autoantibody-mediated arthritis: Critical producers of Fc receptor γ, the receptor for C5a, and lymphocyte function−associated antigen 1

(2010) Paul A. Monach et al.   ARTHRITIS AND RHEUMATISM

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

CCR7 is involved in the migration of neutrophils to lymph nodes

(2010) C. Beauvillain et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC)  2 and PI3K  pathways

(2010) H. Mueller et al.   BLOOD

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

(2010) Richard C. Chou et al.   IMMUNITY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival

(2010) Véronique Witko-Sarsat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection

(2010) Yi-Wei Li et al.   JOURNAL OF HEPATOLOGY

Regulation of leukocyte recruitment by the long pentraxin PTX3

(2010) Livija Deban et al.   NATURE IMMUNOLOGY

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

(2010) D. Kreisel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

(2010) R. J. Snelgrove et al.   SCIENCE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

(2009) M. J. Christopher et al.   BLOOD

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

β2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice

(2009) Aksam Merched et al.   CARDIOVASCULAR RESEARCH

Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma

(2009) Hanne Krogh Jensen et al.   JOURNAL OF CLINICAL ONCOLOGY

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

NETs: a new strategy for using old weapons

(2009) Venizelos Papayannopoulos et al.   TRENDS IN IMMUNOLOGY

Preventing Heart Disease in the 21st Century

(2008) Henry C. McGill et al.   CIRCULATION

Trans-cellular migration: cell–cell contacts get intimate

(2008) Christopher V Carman et al.   CURRENT OPINION IN CELL BIOLOGY

Matrix Metalloproteinase-9/Gelatinase B is a Putative Therapeutic Target of Chronic Obstructive Pulmonary Disease and Multiple Sclerosis

(2008) Q.-X. Sang et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Targeting neutrophil elastase in cystic fibrosis

(2008) Emer Kelly et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Neutrophil apoptosis and the resolution of infection

(2008) Adam D. Kennedy et al.   IMMUNOLOGIC RESEARCH

Human neutrophil elastase: Mediator and therapeutic target in atherosclerosis

(2008) P HENRIKSEN et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

(2008) Braedon McDonald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis

(2008) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis

(2008) Renate Kain et al.   NATURE MEDICINE

Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment

(2008) E. Y. Choi et al.   SCIENCE

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

(2007) Alma Zernecke et al.   CIRCULATION RESEARCH