Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation

Acute immunomodulatory effects of binge alcohol ingestion

(2015) Majid Afshar et al.   ALCOHOL

Purification and Analysis of the Interactions of Caspase-1 and ASC for Assembly of the Inflammasome

(2015) Kannan Badri Narayanan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

CB1-receptor knockout neonatal mice are protected against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation

(2015) Nagaraja N. Nagre et al.   JOURNAL OF NEUROCHEMISTRY

Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB

(2015) Silvia Alfonso-Loeches et al.   NEUROCHEMICAL RESEARCH

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells

(2015) Xiaolan Wang et al.   TOXICOLOGY

Absorption and Peak Blood Alcohol Concentration After Drinking Beer, Wine, or Spirits

(2014) Mack C. Mitchell et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1

(2014) Peter A. Keyel   CYTOKINE

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

GABAA Receptors Containing ρ1 Subunits Contribute to In Vivo Effects of Ethanol in Mice

(2014) Yuri A. Blednov et al.   PLoS One

Alcoholism: A systemic proinflammatory condition

(2014) Emilio González-Reimers   WORLD JOURNAL OF GASTROENTEROLOGY

Dephosphorylation of GluN2B C-terminal tyrosine residues does not contribute to acute ethanol inhibition of recombinant NMDA receptors

(2013) Benjamin A. Hughes et al.   ALCOHOL

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The Size of the Unbranched Aliphatic Chain Determines the Immunomodulatory Potency of Short and Long Chainn-Alkanols

(2013) Damien Carignan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection

(2013) M. T. R. Gomes et al.   JOURNAL OF IMMUNOLOGY

Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations

(2013) Caroline D. Rae et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

The Effect of Alcohols on Red Blood Cell Mechanical Properties and Membrane Fluidity Depends on Their Molecular Size

(2013) Melda Sonmez et al.   PLoS One

Ethanol Inhibits Activation of NLRP3 and AIM2 Inflammasomes in Human Macrophages–A Novel Anti-Inflammatory Action of Alcohol

(2013) Katariina Nurmi et al.   PLoS One

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

Targeting interleukin-1β in CAPS (cryopyrin-associated periodic) syndromes

(2012) Isabelle Koné-Paut et al.   AUTOIMMUNITY REVIEWS

Tyrosine phosphatase inhibition induces an ASC-dependent pyroptosis

(2012) Mohammed G. Ghonime et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The CARD plays a critical role in ASC foci formation and inflammasome signalling

(2012) Martina Proell et al.   BIOCHEMICAL JOURNAL

Ethanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcγR-mediated phagocytosis

(2012) John Karavitis et al.   CELLULAR IMMUNOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion

(2012) Pei-Chun Liao et al.   INFLAMMATION RESEARCH

Tumor necrosis factor-α and interleukin-1β expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7

(2012) J.S. Kim et al.   Molecular Oral Microbiology

Investigation of the Role of TNF-α Converting Enzyme (TACE) in the Inhibition of Cell Surface and Soluble TNF-α Production by Acute Ethanol Exposure

(2012) Kristine von Maltzan et al.   PLoS One

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

(2011) K. Niemi et al.   JOURNAL OF IMMUNOLOGY

Uncoupling Protein 2 Negatively Regulates Mitochondrial Reactive Oxygen Species Generation and Induces Phosphatase-Mediated Anti-Inflammatory Response in Experimental Visceral Leishmaniasis

(2011) W. Basu Ball et al.   JOURNAL OF IMMUNOLOGY

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

Functional Adaptation of the N-Methyl-D-aspartate Receptor to Inhibition by Ethanol Is Modulated by Striatal-Enriched Protein Tyrosine Phosphatase and p38 Mitogen-Activated Protein Kinase

(2011) P. H. Wu et al.   MOLECULAR PHARMACOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Effects of Straight Chain Alcohols on Specific Isoforms of Adenylyl Cyclase

(2010) Mohammad Hasanuzzaman et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Anti-Inflammatory Effects of the Neurotransmitter Agonist Honokiol in a Mouse Model of Allergic Asthma

(2010) M. E. Munroe et al.   JOURNAL OF IMMUNOLOGY

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Inhibitory role for GABA in autoimmune inflammation

(2010) R. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH Oxidase NOX2 Mediates Rapid Cellular Oxidation following ATP Stimulation of Endotoxin-Primed Macrophages

(2009) S. F. Moore et al.   JOURNAL OF IMMUNOLOGY

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE