Drugging the circadian clock feedback cycle to ameliorate cartilage degeneration

Development and characterization of a humanized mouse model of osteoarthritis

(2022) B. Bodic et al.   OSTEOARTHRITIS AND CARTILAGE

Circadian rhythm as a therapeutic target

(2021) Wei Ruan et al.   NATURE REVIEWS DRUG DISCOVERY

Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

(2021) Tianpeng Zhang et al.   Nature Communications

Restoration of the molecular clock is tumor suppressive in neuroblastoma

(2021) Myrthala Moreno-Smith et al.   Nature Communications

Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis

(2020) Jianxi Zhu et al.   eLife

Targeted inhibition of Rev‐erbα/β limits ferroptosis to ameliorate folic acid‐induced acute kidney injury

(2020) Lianxia Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

MicroRNA‐34a‐5p Promotes Joint Destruction during Osteoarthritis

(2020) Helal Endisha et al.   Arthritis & Rheumatology

A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy

(2020) Francesco Dernie et al.   EXPERIMENTAL GERONTOLOGY

Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB

(2019) G. Yuan et al.   OSTEOARTHRITIS AND CARTILAGE

The orphan nuclear receptor RORα is a potential endogenous protector in renal ischemia/reperfusion injury

(2019) Jieru Cai et al.   FASEB JOURNAL

SR9009 has REV-ERB–independent effects on cell proliferation and metabolism

(2019) Pieterjan Dierickx et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice

(2019) Zeng Lin et al.   Frontiers in Pharmacology

Retinoic Acid Receptor-Related Receptor Alpha Ameliorates Autoimmune Arthritis via Inhibiting of Th17 Cells and Osteoclastogenesis

(2019) Jin-Sil Park et al.   Frontiers in Immunology

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease

(2019) Jiyeon Lee et al.   AGING CELL

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

(2018) Quanbo Ji et al.   ANNALS OF THE RHEUMATIC DISEASES

Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain

(2018) Vaskar Das et al.   GENE

Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology

(2018) Masashi Watanave et al.   NEUROBIOLOGY OF DISEASE

Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy

(2017) Yichao Zhao et al.   JOURNAL OF PINEAL RESEARCH

Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides

(2017) Jared L. Zitnay et al.   Nature Communications

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

A validated ultra-performance liquid chromatography-tandem mass spectrometry method to identify the pharmacokinetics of SR8278 in normal and streptozotocin-induced diabetic rats

(2016) Dong Dong et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond

(2016) Francis Berenbaum et al.   Nature Reviews Rheumatology

In vitro models for the study of osteoarthritis

(2016) Craig I. Johnson et al.   VETERINARY JOURNAL

Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism

(2015) Yongjun Wang et al.   ACS Chemical Neuroscience

Integration of the nuclear receptor REV-ERBα linked with circadian oscillators in the expressions ofAlas1, Ppargc1a, andIl6genes in rat granulosa cells

(2015) Huatao Chen et al.   CHRONOBIOLOGY INTERNATIONAL

Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells

(2015) Jun-Kyu Byun et al.   HEPATOLOGY

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase

(2015) Shiva Shajari et al.   JOURNAL OF PINEAL RESEARCH

The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

(2013) Nicole Gossan et al.   ARTHRITIS AND RHEUMATISM

Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ

(2010) Yongjun Wang et al.   ACS Chemical Biology

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE