Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

(2022) Jephte Y. Akakpo et al.   ARCHIVES OF TOXICOLOGY

Hepatic TGFβr1 deficiency attenuates Lipopolysaccharide/D-Galactosamine induced acute liver failure through inhibiting GSK3β-Nrf2-mediated hepatocyte apoptosis and ferroptosis

(2022) Sha Huang et al.   Cellular and Molecular Gastroenterology and Hepatology

The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice

(2022) Olamide B. Adelusi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men

(2022) S.C. Broome et al.   Redox Biology

Treatment of Drug-Induced Liver Injury

(2022) Rolf Teschke   Biomedicines

MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/Drp1 pathway

(2021) Lei Hou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development

(2021) Anup Ramachandran et al.   ANTIOXIDANTS & REDOX SIGNALING

Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

(2021) Yaqing Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?

(2021) Hartmut Jaeschke et al.   GENE EXPRESSION

The mitochondria-targeting antioxidant MitoQ alleviated Lipopolysaccharide/ D-galactosamine-induced acute liver injury in mice

(2021) Kai Hu et al.   IMMUNOLOGY LETTERS

Vitamin D deficiency exacerbates hepatic oxidative stress and inflammation during acetaminophen-induced acute liver injury in mice

(2021) Ya-Qi Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitochondrial regulation of ferroptosis

(2021) Boyi Gan   JOURNAL OF CELL BIOLOGY

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

(2021) Jose C. Fernandez-Checa et al.   JOURNAL OF HEPATOLOGY

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

(2021) Hartmut Jaeschke et al.   Acta Pharmaceutica Sinica B

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

A mitochondrial journey through acetaminophen hepatotoxicity

(2020) Anup Ramachandran et al.   FOOD AND CHEMICAL TOXICOLOGY

Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization

(2020) Hereward J. Wimborne et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome

(2020) Jing Yang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The development and hepatotoxicity of acetaminophen: reviewing over a century of progress

(2020) Mitchell R. McGill et al.   DRUG METABOLISM REVIEWS

Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction

(2020) K. J. Botting et al.   Science Advances

Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment

(2020) Qian Jiang et al.   Oxidative Medicine and Cellular Longevity

CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy

(2020) Peiwen Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

(2020) Nga T. Nguyen et al.   TOXICOLOGY LETTERS

Emerging and established modes of cell death during acetaminophen-induced liver injury

(2019) Hartmut Jaeschke et al.   ARCHIVES OF TOXICOLOGY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

(2018) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Mitochondria-targeted antioxidants

(2015) Anne O. Oyewole et al.   FASEB JOURNAL

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

(2011) Anup Ramachandran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes

(2010) Hui-Min Yan et al.   TOXICOLOGICAL SCIENCES

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY