UBXD8 mediates mitochondria‐associated degradation to restrain apoptosis and mitophagy

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3

(2021) Logan P. Poole et al.   Scientific Reports

Quality control of the mitochondrial proteome

(2020) Jiyao Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress

(2019) Fei-Yun Chen et al.   JOURNAL OF CELL BIOLOGY

Molecular pathways of mitochondrial outer membrane protein degradation

(2019) Jing Zheng et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The NADH Dehydrogenase Nde1 Executes Cell Death after Integrating Signals from Metabolism and Proteostasis on the Mitochondrial Surface

(2019) SreeDivya Saladi et al.   MOLECULAR CELL

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons

(2017) Marthe H. R. Ludtmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics

(2017) Edward Cherok et al.   MOLECULAR BIOLOGY OF THE CELL

Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants

(2017) Ting Zhang et al.   eLife

The coming of age of the mitochondria–ER contact: a matter of thickness

(2016) M Giacomello et al.   CELL DEATH AND DIFFERENTIATION

Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage

(2016) Weihua Zhou et al.   CLINICAL CANCER RESEARCH

Doa1 targets ubiquitinated substrates for mitochondria-associated degradation

(2016) Xi Wu et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein

(2016) Shan Xu et al.   MOLECULAR BIOLOGY OF THE CELL

The Emerging Network of Mitochondria-Organelle Contacts

(2016) Andrew Murley et al.   MOLECULAR CELL

Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains

(2016) Bianca Schrul et al.   NATURE CELL BIOLOGY

Distinct mechanisms controlling rough and smooth endoplasmic reticulum contacts with mitochondria

(2015) P. T. C. Wang et al.   JOURNAL OF CELL SCIENCE

Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells

(2015) K. D. Elgass et al.   JOURNAL OF CELL SCIENCE

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

(2014) Jina Yun et al.   eLife

RNF185 Is a Novel E3 Ligase of Endoplasmic Reticulum-associated Degradation (ERAD) That Targets Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

(2013) Elma El Khouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

(2013) Fernando Bartolome et al.   NEURON

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

(2013) Nam Chul Kim et al.   NEURON

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

(2013) James A. Olzmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets

(2012) Michitaka Suzuki et al.   MOLECULAR BIOLOGY OF THE CELL

Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice

(2012) H Z Yin et al.   Cell Death & Disease

Urban planning of the endoplasmic reticulum (ER): How diverse mechanisms segregate the many functions of the ER

(2011) Emily M. Lynes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

(2011) Mariusz Karbowski et al.   CURRENT OPINION IN CELL BIOLOGY

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

The Tissue-Specific Rep8/UBXD6 Tethers p97 to the Endoplasmic Reticulum Membrane for Degradation of Misfolded Proteins

(2011) Louise Madsen et al.   PLoS One

Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model

(2011) Ya-Chu Chang et al.   PLoS Genetics

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone

(2010) Sara K. Custer et al.   HUMAN MOLECULAR GENETICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

(2010) J. N. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets

(2009) J. K. Zehmer et al.   JOURNAL OF CELL SCIENCE

Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation

(2009) D. Halawani et al.   MOLECULAR AND CELLULAR BIOLOGY

BH3-only proteins and their roles in programmed cell death

(2009) M Giam et al.   ONCOGENE

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unsaturated Fatty Acids Inhibit Proteasomal Degradation of Insig-1 at a Postubiquitination Step

(2008) Joon No Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

(2008) B. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA