Doa1 targets ubiquitinated substrates for mitochondria-associated degradation

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins

(2014) Y.-C. Chen et al.   EMBO JOURNAL

The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

(2014) V. Okreglak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation

(2013) Kunio Nakatsukasa et al.   MOLECULAR BIOLOGY OF THE CELL

Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

(2013) Fernando Bartolome et al.   NEURON

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

(2013) Nam Chul Kim et al.   NEURON

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1

(2012) Eric B. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial redox signalling at a glance

(2012) Yvonne Collins et al.   JOURNAL OF CELL SCIENCE

Cdc48p/p97-mediated regulation of mitochondrial morphology is Vms1p-independent

(2012) Masatoshi Esaki et al.   JOURNAL OF STRUCTURAL BIOLOGY

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology

(2012) Angèle Nalbandian et al.   PLoS One

Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy

(2012) C. Bebeacua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice

(2012) H Z Yin et al.   Cell Death & Disease

Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

(2011) Mariusz Karbowski et al.   CURRENT OPINION IN CELL BIOLOGY

Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion

(2011) F. Anton et al.   JOURNAL OF CELL SCIENCE

Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation

(2011) Xi Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

Cdc48: a power machine in protein degradation

(2011) Alexandra Stolz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model

(2011) Ya-Chu Chang et al.   PLoS Genetics

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone

(2010) Sara K. Custer et al.   HUMAN MOLECULAR GENETICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

(2010) Shan Xu et al.   MOLECULAR BIOLOGY OF THE CELL

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

(2010) Natasha Pashkova et al.   MOLECULAR CELL

A Stress-Responsive System for Mitochondrial Protein Degradation

(2010) Jin-Mi Heo et al.   MOLECULAR CELL

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

Structural Basis for Ubiquitin Recognition by a Novel Domain from Human Phospholipase A2-activating Protein

(2009) Qing-Shan Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Function of the PLAA/Ufd3-p97/Cdc48 Complex

(2009) Liyan Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitylation machinery of the endoplasmic reticulum

(2009) Christian Hirsch et al.   NATURE

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation

(2009) G. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

Ubiquitin–Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion

(2008) Mickael M.J. Cohen et al.   MOLECULAR BIOLOGY OF THE CELL