Molecular pathways of mitochondrial outer membrane protein degradation

Mitochondrial AAA‐ATPase Msp1 detects mislocalized tail‐anchored proteins through a dual‐recognition mechanism

(2019) Lanlan Li et al.   EMBO REPORTS

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

Mechanisms and functions of ribosome-associated protein quality control

(2019) Claudio A. P. Joazeiro   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

(2019) Ian Cooney et al.   SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Beyond ER: Regulating TOM-Complex-Mediated Import by Ubx2

(2019) Mohamed A. Eldeeb et al.   TRENDS IN CELL BIOLOGY

Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins

(2019) Verena Dederer et al.   eLife

Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER

(2019) Shunsuke Matsumoto et al.   MOLECULAR CELL

Protein Quality Control of the Endoplasmic Reticulum and Ubiquitin–Proteasome-Triggered Degradation of Aberrant Proteins: Yeast Pioneers the Path

(2018) Nicole Berner et al.   Annual Review of Biochemistry

A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy

(2018) Juliette Piard et al.   BRAIN

Mechanistic insights into ER-associated protein degradation

(2018) Xudong Wu et al.   CURRENT OPINION IN CELL BIOLOGY

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest

(2018) Lindsey A Allan et al.   EMBO JOURNAL

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL

(2018) Yanfang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

Vms1p is a release factor for the ribosome-associated quality control complex

(2018) Olga Zurita Rendón et al.   Nature Communications

Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1

(2018) Kazushige Kuroha et al.   MOLECULAR CELL

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes

(2018) Rati Verma et al.   NATURE

Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45

(2017) Xi Wu et al.   JOURNAL OF CELL BIOLOGY

Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics

(2017) Edward Cherok et al.   MOLECULAR BIOLOGY OF THE CELL

Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria

(2017) Janos Steffen et al.   MOLECULAR BIOLOGY OF THE CELL

Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria

(2017) Jason R. Nielson et al.   MOLECULAR CELL

Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins

(2017) Matthew L. Wohlever et al.   MOLECULAR CELL

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system

(2017) Piotr Bragoszewski et al.   Open Biology

The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane

(2017) Nicholas R Weir et al.   eLife

Doa1 targets ubiquitinated substrates for mitochondria-associated degradation

(2016) Xi Wu et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein

(2016) Shan Xu et al.   MOLECULAR BIOLOGY OF THE CELL

The Emerging Network of Mitochondria-Organelle Contacts

(2016) Andrew Murley et al.   MOLECULAR CELL

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation

(2016) Bianca Hartmann et al.   eLife

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

(2015) J.-R. Liang et al.   EMBO REPORTS

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

Retro-translocation of mitochondrial intermembrane space proteins

(2015) Piotr Bragoszewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel mutation in VCP causes Charcot–Marie–Tooth Type 2 disease

(2014) Michael A. Gonzalez et al.   BRAIN

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins

(2014) Y.-C. Chen et al.   EMBO JOURNAL

A novel import route for an N-anchor mitochondrial outer membrane protein aided by the TIM23 complex

(2014) J. Song et al.   EMBO REPORTS

The presequence pathway is involved in protein sorting to the mitochondrial outer membrane

(2014) L.-S. Wenz et al.   EMBO REPORTS

Dynamic survey of mitochondria by ubiquitin

(2014) M. Escobar-Henriques et al.   EMBO REPORTS

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

(2014) V. Okreglak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling

(2014) C. C. Williams et al.   SCIENCE

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase

(2013) Min Fu et al.   MOLECULAR BIOLOGY OF THE CELL

Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

(2013) Fernando Bartolome et al.   NEURON

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

(2013) Nam Chul Kim et al.   NEURON

Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1

(2012) Eric B. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Saccharomyces cerevisiaePorin Pore Forms Complexes with Mitochondrial Outer Membrane Proteins Om14p and Om45p

(2012) Susann Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Characteristics of the turnover of uncoupling protein 3 by the ubiquitin proteasome system in isolated mitochondria

(2011) Shona A. Mookerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial AAA proteases — Towards a molecular understanding of membrane-bound proteolytic machines

(2011) Florian Gerdes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

(2011) Mariusz Karbowski et al.   CURRENT OPINION IN CELL BIOLOGY

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quality Control of Mitochondrial Proteostasis

(2011) M. J. Baker et al.   Cold Spring Harbor Perspectives in Biology

IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation

(2010) Giovanni Benard et al.   EMBO JOURNAL

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Degradation of an intramitochondrial protein by the cytosolic proteasome

(2010) V. Azzu et al.   JOURNAL OF CELL SCIENCE

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

(2010) Shan Xu et al.   MOLECULAR BIOLOGY OF THE CELL

A Stress-Responsive System for Mitochondrial Protein Degradation

(2010) Jin-Mi Heo et al.   MOLECULAR CELL

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid turnover of mitochondrial uncoupling protein 3

(2009) Vian Azzu et al.   BIOCHEMICAL JOURNAL

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Biogenesis of mitochondrial outer membrane proteins

(2008) Dirk M. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL