Unfolded protein response IRE1 / XBP1 signaling is required for healthy mammalian brain aging
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Title
Unfolded protein response
IRE1
/
XBP1
signaling is required for healthy mammalian brain aging
Authors
Keywords
-
Journal
EMBO JOURNAL
Volume -, Issue -, Pages -
Publisher
EMBO
Online
2022-10-31
DOI
10.15252/embj.2022111952
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Note: Only part of the references are listed.- Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice
- (2022) Jennifer M. Hafycz et al. AGING CELL
- Adapting the proteostasis capacity to sustain brain healthspan
- (2021) Claudio Hetz CELL
- Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease
- (2021) Mauricio M. Oliveira et al. Science Signaling
- Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease
- (2021) Liang He et al. Translational Psychiatry
- Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans
- (2020) Ashley E. Frakes et al. SCIENCE
- UPRER promotes lipophagy independent of chaperones to extend life span
- (2020) Joseph R. Daniele et al. Science Advances
- Mechanisms, regulation and functions of the unfolded protein response
- (2020) Claudio Hetz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks
- (2020) Corinne Abbadie et al. TRENDS IN BIOCHEMICAL SCIENCES
- Small molecule cognitive enhancer reverses age-related memory decline in mice
- (2020) Karen Krukowski et al. eLife
- Reaction to Endoplasmic Reticulum Stress via ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging
- (2019) Tino Prell et al. Frontiers in Aging Neuroscience
- XBP-1 Remodels Lipid Metabolism to Extend Longevity
- (2019) Soudabeh Imanikia et al. Cell Reports
- Loss of XBP1 Leads to Early-Onset Retinal Neurodegeneration in a Mouse Model of Type I Diabetes
- (2019) Todd McLaughlin et al. Journal of Clinical Medicine
- Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults
- (2019) Corey R. Hart et al. Aging-US
- Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis
- (2019) Latika Matai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER
- (2019) Robert Thomas Schinzel et al. CELL
- The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway
- (2018) Daniel Hughes et al. FEBS Journal
- Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
- (2018) Darren J. Baker et al. JOURNAL OF CLINICAL INVESTIGATION
- ER Proteostasis Control of Neuronal Physiology and Synaptic Function
- (2018) Gabriela Martínez et al. TRENDS IN NEUROSCIENCES
- Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
- (2018) Claudio Soto et al. NATURE NEUROSCIENCE
- Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
- (2018) Danilo B. Medinas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The PRIDE database and related tools and resources in 2019: improving support for quantification data
- (2018) Yasset Perez-Riverol et al. NUCLEIC ACIDS RESEARCH
- STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
- (2018) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma
- (2017) Atsushi Saito et al. JOURNAL OF NEUROCHEMISTRY
- Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties
- (2017) Vijendra Sharma et al. JOURNAL OF NEUROSCIENCE
- ER stress and the unfolded protein response in neurodegeneration
- (2017) Claudio Hetz et al. Nature Reviews Neurology
- The unfolded protein response: mechanisms and therapy of neurodegeneration
- (2016) Heather L. Smith et al. BRAIN
- Aging and the UPR(ER)
- (2016) Rebecca C. Taylor BRAIN RESEARCH
- Specialization of biosynthetic membrane trafficking for neuronal form and function
- (2016) Cyril Hanus et al. CURRENT OPINION IN NEUROBIOLOGY
- Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
- (2016) Maxim V. Kuleshov et al. NUCLEIC ACIDS RESEARCH
- Emerging Roles for the Unfolded Protein Response in the Developing Nervous System
- (2016) Juliette D. Godin et al. TRENDS IN NEUROSCIENCES
- Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction
- (2016) Nuno Miguel Luis et al. Cell Reports
- Regulation of Memory Formation by the Transcription Factor XBP1
- (2016) Gabriela Martínez et al. Cell Reports
- WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning
- (2016) George L. Sutphin et al. PLoS Computational Biology
- Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
- (2016) Lars Plate et al. eLife
- S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction
- (2015) L. Yang et al. SCIENCE
- PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress
- (2015) Lifen Wang et al. PLoS Genetics
- Activation of the unfolded protein response in aged human lenses
- (2015) HE-ZHEN TANG et al. Molecular Medicine Reports
- Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1
- (2014) Lisa M. Ryno et al. ACS Chemical Biology
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Proteostasis and the Aging Proteome in Health and Disease
- (2014) R. I. Morimoto et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
- (2014) P. Valdes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Getting RIDD of RNA: IRE1 in cell fate regulation
- (2014) M. Maurel et al. TRENDS IN BIOCHEMICAL SCIENCES
- XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
- (2013) Rebecca C. Taylor et al. CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
- (2013) Mychael V. Lourenco et al. Cell Metabolism
- Polymorphism −116C/G of Human X-box-Binding Protein 1 Promoter is Associated with Risk of Alzheimer's Disease
- (2013) Sheng-Yuan Liu et al. CNS Neuroscience & Therapeutics
- Cleaning up the masses: Exclusion lists to reduce contamination with HPLC-MS/MS
- (2013) Kelly Hodge et al. Journal of Proteomics
- Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
- (2013) Tao Ma et al. NATURE NEUROSCIENCE
- Object recognition test in mice
- (2013) Marianne Leger et al. Nature Protocols
- Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis
- (2013) Marishka K. Brown et al. NEUROBIOLOGY OF AGING
- Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory
- (2013) Mimi A. Trinh et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Fold change and p-value cutoffs significantly alter microarray interpretations
- (2012) Mark R Dalman et al. BMC BIOINFORMATICS
- IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
- (2012) Kyu Yeon Hur et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The ageing cortical synapse: hallmarks and implications for cognitive decline
- (2012) John H. Morrison et al. NATURE REVIEWS NEUROSCIENCE
- Dendritic spine changes associated with normal aging
- (2012) D.L. Dickstein et al. NEUROSCIENCE
- Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
- (2012) A. O. Ardiles et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endoplasmic reticulum stress in wake-active neurons progresses with aging
- (2011) Nirinjini Naidoo et al. AGING CELL
- The ER stress factor XBP1s prevents amyloid-β neurotoxicity
- (2011) Sergio Casas-Tinto et al. HUMAN MOLECULAR GENETICS
- Spatio-temporal transcriptome of the human brain
- (2011) Hyo Jung Kang et al. NATURE
- Dual and opposing roles of the unfolded protein response regulated by IRE1 and XBP1 in proinsulin processing and insulin secretion
- (2011) A.-H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
- (2010) S. Henis-Korenblit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
- (2009) Florence Debacq-Chainiaux et al. Nature Protocols
- Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
- (2009) A. Ben-Zvi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1
- (2008) Akiko Hayashi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling
- (2008) N. Naidoo et al. JOURNAL OF NEUROSCIENCE
- Gene expression changes in the course of normal brain aging are sexually dimorphic
- (2008) N. C. Berchtold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection of bursts in neuronal spike trains by the mean inter-spike interval method
- (2008) Lin Chen et al. Progress in Natural Science-Materials International
- Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
- (2008) A.-H. Lee et al. SCIENCE
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