Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinolone

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

(2022) Raquel Viana et al.   NATURE

Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies

(2022) Sascha Berlansky et al.   Cells

Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition

(2022) Vanna Sanna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quantum Mechanics/Molecular Mechanics Studies on the Catalytic Mechanism of a Novel Esterase (FmtA) of Staphylococcus aureus

(2022) Vikram Dalal et al.   Journal of Chemical Information and Modeling

Leveraging Bulk and Single-Cell RNA Sequencing Data of NSCLC Tumor Microenvironment and Therapeutic Potential of NLOC-15A, A Novel Multi-Target Small Molecule

(2022) Bashir Lawal et al.   Frontiers in Immunology

Preclinical anti-inflammatory and antioxidant effects of Azanza garckeana in STZ-induced glycemic-impaired rats, and pharmacoinformatics of it major phytoconstituents

(2022) Bashir Lawal et al.   BIOMEDICINE & PHARMACOTHERAPY

COVID-19 vaccines: where we stand and challenges ahead

(2021) Guido Forni et al.   CELL DEATH AND DIFFERENTIATION

Synthetic and Medicinal Perspective of Quinolines as Antiviral Agents

(2021) Ramandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines

(2021) Bashir Lawal et al.   Biomedicines

Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments

(2021) Sareh Pandamooz et al.   Annual Review of Pharmacology and Toxicology

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

(2021) Wendy P. Painter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study

(2021) Cristina Menni et al.   LANCET INFECTIOUS DISEASES

SARS-CoV-2 Infection after Vaccination in Health Care Workers in California

(2021) Jocelyn Keehner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Incident SARS-CoV-2 Infection among mRNA-Vaccinated and Unvaccinated Nursing Home Residents

(2021) Elizabeth M. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19

(2021) Jerald Sadoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Rise and Fall of Chloroquine/Hydroxychloroquine as Compassionate Therapy of COVID-19

(2021) Elangovan Manivannan et al.   Frontiers in Pharmacology

mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2′,4′-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implications

(2021) Bashir Lawal et al.   Frontiers in Oncology

Decoding molnupiravir-induced mutagenesis in SARS-CoV-2

(2021) Luis Menéndez-Arias   JOURNAL OF BIOLOGICAL CHEMISTRY

In the face of the future, what do we learn from COVID-19?

(2021) Amr Ahmed EL-Arabey et al.   Human Vaccines & Immunotherapeutics

Are the new SARS-CoV-2 variants resistant against the vaccine?

(2021) Mohnad Abdalla et al.   Human Vaccines & Immunotherapeutics

Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives

(2021) Bashir Lawal et al.   Frontiers in Pharmacology

Identification of Cancer Hub Gene Signatures Associated with Immune-Suppressive Tumor Microenvironment and Ovatodiolide as a Potential Cancer Immunotherapeutic Agent

(2021) Jia-Hong Chen et al.   Cancers

In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer

(2021) Bashir Lawal et al.   Journal of Inflammation Research

Elucidating causes of COVID-19 infection and related deaths after vaccination

(2021) Vijay Kumar Jain et al.   Diabetes & Metabolic Syndrome-Clinical Research & Reviews

What are the challenges faced by COVID-19 vaccines?

(2021) Mohnad Abdalla et al.   Expert Review of Vaccines

Structure of dye-decolorizing peroxidase from Bacillus subtilis in complex with veratryl alcohol

(2021) Poonam Dhankhar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Characterization of the novel SARS‐CoV‐2 Omicron (B.1.1.529) variant of concern and its global perspective

(2021) Shailendra K. Saxena et al.   JOURNAL OF MEDICAL VIROLOGY

Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic

(2021) Salim S Abdool Karim et al.   LANCET

Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19

(2021) Mohd. Imran et al.   MOLECULES

Severity of Illness in Persons Infected With the SARS-CoV-2 Delta Variant vs Beta Variant in Qatar

(2021) Adeel A. Butt et al.   JAMA Internal Medicine

Transcriptomic-Based Identification of the Immuno-Oncogenic Signature of Cholangiocarcinoma for HLC-018 Multi-Target Therapy Exploration

(2021) Bashir Lawal et al.   Cells

Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates

(2021) Yuan-Chieh Yeh et al.   Biomedicines

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

(2020) Janet Olayemi Olugbodi et al.   MOLECULES

Rethinking the role of hydroxychloroquine in the treatment of COVID‐19

(2020) Eric A. Meyerowitz et al.   FASEB JOURNAL

Hydroxychloroquine and Azithromycin to Treat Patients With COVID‐19: Both Friends and Foes?

(2020) Bruno Mégarbane et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology

(2020) Jose de Leon et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Hydroxychloroquine in the Treatment of COVID-19: A Multicenter Randomized Controlled Study

(2020) Sherief Abd-Elsalam et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Characterization of dye-decolorizing peroxidase from Bacillus subtilis

(2020) Poonam Dhankhar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19

(2020) Zi-Ning Lei et al.   PHARMACOLOGY & THERAPEUTICS

COVID-19 mortality risk for older men and women

(2020) N. David Yanez et al.   BMC PUBLIC HEALTH

Frontrunners in the race to develop a SARS-CoV-2 vaccine

(2020) Raquel Russell et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Reinfection with SARS-CoV-2: Implications for Vaccines

(2020) Jeffrey I Cohen et al.   CLINICAL INFECTIOUS DISEASES

T Cell Memory: Understanding COVID-19

(2020) Nicholas N. Jarjour et al.   IMMUNITY

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

DFT and molecular docking study of chloroquine derivatives as antiviral to coronavirus COVID-19

(2020) Olfa Noureddine et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Anti-inflammatory activity of chloroquine and amodiaquine through p21-mediated suppression of T cell proliferation and Th1 cell differentiation

(2016) Sera Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assessing the Growth of Bioactive Compounds and Scaffolds over Time: Implications for Lead Discovery and Scaffold Hopping

(2016) Swarit Jasial et al.   Journal of Chemical Information and Modeling

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Comprehensive review on current developments of quinoline-based anticancer agents

(2016) Shweta Jain et al.   Arabian Journal of Chemistry

Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy

(2016) Vita Golubovskaya et al.   Cancers

Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents

(2015) Tsung-Chih Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research

(2014) Haibin Liu et al.   Journal of Chemical Information and Modeling

Chloroquine inhibits MGC803 gastric cancer cell migration via the Toll-like receptor 9/nuclear factor kappa B signaling pathway

(2014) YANLI ZHANG et al.   Molecular Medicine Reports

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Medicinal Chemistry of Quinolines As Emerging Anti-inflammatory Agents: An Overview

(2013) S. Mukherjee et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis, characterization, antimicrobial, anticancer, and antituberculosis activity of some new pyrazole, isoxazole, pyrimidine and benzodiazepine derivatives containing thiochromeno and benzothiepino moieties

(2013) Pandaram Palanisamy et al.   RSC Advances

Molecular Docking: A Powerful Approach for Structure-Based Drug Discovery

(2012) Xuan-Yu Meng et al.   Current Computer-Aided Drug Design

Synthesis and antitumor activities of a new series of 4,5-dihydro-1H-thiochromeno[4,3-d]pyrimidine derivatives

(2012) DeXiang Guo et al.   Science China-Chemistry

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

Pharmacokinetics of Venlafaxine Extended Release 75 mg and Desvenlafaxine 50 mg in Healthy CYP2D6 Extensive and Poor Metabolizers

(2011) Alice I. Nichols et al.   CLINICAL DRUG INVESTIGATION

Th17 cells and regulatory T cells in elite control over HIV and SIV

(2011) Dennis J Hartigan-OʼConnor et al.   Current Opinion in HIV and AIDS

Quinolines and structurally related heterocycles as antimalarials

(2010) Kirandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological Activities of Quinoline Derivatives

(2010) Suresh Kumar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Design, Synthesis and Development of Novel Camptothecin Drugs

(2008) Siong Liew et al.   CURRENT PHARMACEUTICAL DESIGN

GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function

(2008) Sara Mostafavi et al.   GENOME BIOLOGY