Pro-Oncogenic c-Met/EGFR, Biomarker Signatures of the Tumor Microenvironment are Clinical and Therapy Response Prognosticators in Colorectal Cancer, and Therapeutic Targets of 3-Phenyl-2H-benzo[e][1,3]-Oxazine-2,4(3H)-Dione Derivatives

Updated Insights on EGFR Signaling Pathways in Glioma

(2021) Alexandru Oprita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines

(2021) Bashir Lawal et al.   Biomedicines

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

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(2021) Georgina E. Wood et al.   ONCOGENE

Multi-Omics Data Analysis of Gene Expressions and Alterations, Cancer-Associated Fibroblast and Immune Infiltrations, Reveals the Onco-Immune Prognostic Relevance of STAT3/CDK2/4/6 in Human Malignancies

(2021) Bashir Lawal et al.   Cancers

mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 Are Druggable Candidates for N-(2,4-Difluorophenyl)-2′,4′-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), With Consequent Anticancer Implications

(2021) Bashir Lawal et al.   Frontiers in Oncology

Colorectal cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Computer-aided prediction of biological activity spectra for organic compounds: the possibilities and limitations

(2020) V. V. Poroikov et al.   RUSSIAN CHEMICAL BULLETIN

Global Burden of 5 Major Types Of Gastrointestinal Cancer

(2020) Melina Arnold et al.   GASTROENTEROLOGY

Genetic alterations in epidermal growth factor receptor‑tyrosine kinase inhibitor‑na�ve non‑small cell lung carcinoma

(2020) Takumi Yamaura et al.   Oncology Letters

Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer

(2020) Beatrice Gini et al.   Journal of Thoracic Disease

Targeting STAT3 in Cancer Immunotherapy

(2020) Sailan Zou et al.   Molecular Cancer

De Novo T790M Mutation in an L858R Epidermal Growth Factor Receptor Mutant-Associated Lung Adenocarcinoma

(2020) Takumi Fujiwara et al.   Cancers

HNC0014, a Multi-Targeted Small-Molecule, Inhibits Head and Neck Squamous Cell Carcinoma by Suppressing c-Met/STAT3/CD44/PD-L1 Oncoimmune Signature and Eliciting Antitumor Immune Responses

(2020) Jih-Chin Lee et al.   Cancers

Concurrent Genetic Alterations and Other Biomarkers Predict Treatment Efficacy of EGFR-TKIs in EGFR-Mutant Non-Small Cell Lung Cancer: A Review

(2020) Yijia Guo et al.   Frontiers in Oncology

Activation of c-Met in cancer cells mediates growth-promoting signals against oxidative stress through Nrf2-HO-1

(2019) Samik Chakraborty et al.   Oncogenesis

MEXPRESS update 2019

(2019) Alexander Koch et al.   NUCLEIC ACIDS RESEARCH

The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions

(2019) Steven K Clinton et al.   JOURNAL OF NUTRITION

Targeting of the Cancer-Associated Fibroblast—T-Cell Axis in Solid Malignancies

(2019) Tom J. Harryvan et al.   Journal of Clinical Medicine

Molecular docking studies on the interaction of NCI anticancer analogues with human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit

(2019) David Ebuka Arthur et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

Cancer-associated fibroblasts promote epithelial-mesenchymal transition and EGFR-TKI resistance of non-small cell lung cancers via HGF/IGF-1/ANXA2 signaling

(2018) Yanmei Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

(2018) Elham Azizi et al.   CELL

Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities

(2018) Yazhuo Zhang et al.   Molecular Cancer

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies

(2018) Zhenyi An et al.   ONCOGENE

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Coexistent genetic alterations involving ALK, RET, ROS1 or MET in 15 cases of lung adenocarcinoma

(2017) Zhenya Tang et al.   MODERN PATHOLOGY

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR

(2017) T-S Lau et al.   ONCOGENE

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

(2017) Oliver M.T. Pearce et al.   Cancer Discovery

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

A global view on cancer incidence and national levels of the human development index

(2016) Miranda M. Fidler et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

(2016) Eunice Yuen Ting Lau et al.   Cell Reports

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

(2015) Khalid O Alfarouk et al.   Cancer Cell International

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

PLIP: fully automated protein–ligand interaction profiler

(2015) Sebastian Salentin et al.   NUCLEIC ACIDS RESEARCH

Blood-brain barrier dysfunction in disorders of the developing brain

(2015) Raffaella Moretti et al.   Frontiers in Neuroscience

Genetic and Functional Diversity of Propagating Cells in Glioblastoma

(2015) Sara G.M. Piccirillo et al.   Stem Cell Reports

Colorectal cancer

(2015) Ernst J. Kuipers et al.   Nature Reviews Disease Primers

Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date

(2014) Jayson I. L. Bastien et al.   CANCER

AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research

(2014) Haibin Liu et al.   Journal of Chemical Information and Modeling

Modified Salicylanilide and 3-Phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption

(2014) Chun-Liang Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2013) David Gfeller et al.   BIOINFORMATICS

Microenvironment and tumor cell plasticity: An easy way out

(2013) Maria Letizia Taddei et al.   CANCER LETTERS

Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery

(2013) Michael P. Lisanti et al.   CELL CYCLE

Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention

(2013) Dora Colussi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

Hydrogen Bonding Penalty upon Ligand Binding

(2011) Hongtao Zhao et al.   PLoS One

The role of the c-Met pathway in lung cancer and the potential for targeted therapy

(2011) Martin Sattler et al.   Therapeutic Advances in Medical Oncology

An overview of the c-MET signaling pathway

(2011) Shawna Leslie Organ et al.   Therapeutic Advances in Medical Oncology

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

Multiple Drug Resistance Mechanisms in Cancer

(2010) Bruce C. Baguley   MOLECULAR BIOTECHNOLOGY

Analysis of Food and Drug Administration-Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines

(2010) S. L. Holbeck et al.   MOLECULAR CANCER THERAPEUTICS

PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

(2010) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

Optimized Hydrophobic Interactions and Hydrogen Bonding at the Target-Ligand Interface Leads the Pathways of Drug-Designing

(2010) Rohan Patil et al.   PLoS One

Linking somatic genetic alterations in cancer to therapeutics

(2009) Darrin Stuart et al.   CURRENT OPINION IN CELL BIOLOGY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

DNA fingerprinting of the NCI-60 cell line panel

(2009) P. L. Lorenzi et al.   MOLECULAR CANCER THERAPEUTICS

Topological Polar Surface Area: A Useful Descriptor in 2D-QSAR

(2008) S. Prasanna et al.   CURRENT MEDICINAL CHEMISTRY

Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis

(2008) William M. Grady et al.   GASTROENTEROLOGY