The role of PP2A /NLRP3 signaling pathway in ambient particulate matter 2.5 induced lung injury

Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury

(2022) Zihe Zhai et al.   Bioactive Materials

Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling

(2021) Steven P. Cass et al.   Frontiers in Immunology

Potential molecular mechanism of cardiac hypertrophy in mice induced by exposure to ambient PM2.5

(2021) Qingping Liu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The mitochondria-targeted antioxidant MitoQ attenuated PM2.5-induced vascular fibrosis via regulating mitophagy

(2021) Ruihong Ning et al.   Redox Biology

Mechanisms of ultrafine particle-induced respiratory health effects

(2020) George D. Leikauf et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A review of atmospheric benzene homologues in China: Characterization, health risk assessment, source identification and countermeasures

(2020) Yuanyuan Ji et al.   Journal of Environmental Sciences-China

The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation

(2020) Yang Zhou et al.   Cells

Concentrations and mortality due to short- and long-term exposure to PM2.5 in a megacity of Iran (2014–2019)

(2020) Yaghoub Hajizadeh et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis

(2020) Franco Conforti et al.   Cell Death Discovery

Air pollution characteristics and human health risks in key cities of northwest China

(2020) Haiping Luo et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Protein Phosphatase 2A Reduces Cigarette Smoke-Induced Cathepsin S and Loss of Lung Function

(2019) Declan F Doherty et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

(2019) Aaron Talty et al.   Cell Death & Disease

Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence

(2019) Karan Sachdeva et al.   Frontiers in Immunology

Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice

(2018) Cynthia Lebeaupin et al.   HEPATOLOGY

PM2.5 induces autophagy-mediated cell death via NOS2 signaling in human bronchial epithelium cells

(2018) Xiao-Ming Zhu et al.   International Journal of Biological Sciences

Protein corona of airborne nanoscale PM2.5 induces aberrant proliferation of human lung fibroblasts based on a 3D organotypic culture

(2018) Yan Li et al.   Scientific Reports

The airway inflammation induced by nasal inoculation of PM2.5 and the treatment of bacterial lysates in rats

(2018) Yang Shen et al.   Scientific Reports

NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter

(2018) Runxiao Zheng et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

TMT-Based Quantitative Proteomics Analysis Reveals Airborne PM2.5-Induced Pulmonary Fibrosis

(2018) Shan Liu et al.   International Journal of Environmental Research and Public Health

Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

(2017) Daniela Schwotzer et al.   Particle and Fibre Toxicology

The health effects of ambient PM2.5 and potential mechanisms

(2016) Shaolong Feng et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Investigation of selenium pretreatment in the attenuation of lung injury in rats induced by fine particulate matters

(2016) Jie Liu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung

(2016) Ismini Lasithiotaki et al.   EUROPEAN RESPIRATORY JOURNAL

EP4 Receptor–Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice

(2016) Sei Higuchi et al.   JOURNAL OF IMMUNOLOGY

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

(2016) L. A. Borthwick   Seminars in Immunopathology

Aeroparticles, Composition, and Lung Diseases

(2016) Carlos I. Falcon-Rodriguez et al.   Frontiers in Immunology

Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo

(2015) Zhiqin Shi et al.   JOURNAL OF HAZARDOUS MATERIALS

Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine Production

(2015) Sena Kim et al.   JOURNAL OF IMMUNOLOGY

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area

(2015) Errol M. Thomson et al.   Particle and Fibre Toxicology

The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles

(2015) Virginie Rabolli et al.   Particle and Fibre Toxicology

α1-Antitrypsin Activates Protein Phosphatase 2A to Counter Lung Inflammatory Responses

(2014) Patrick Geraghty et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Glutathione Peroxidase 1–Protein Tyrosine Phosphatase 1B–Protein Phosphatase 2A Axis. A Key Determinant of Airway Inflammation and Alveolar Destruction

(2013) Patrick Geraghty et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

(2013) Quan Qiu et al.   EMBO JOURNAL

The health significance of gas- and particle-phase terpene oxidation products: A review

(2013) Annette C. Rohr   ENVIRONMENT INTERNATIONAL

Chemical constituents of fine particulate air pollution and pulmonary function in healthy adults: The Healthy Volunteer Natural Relocation study

(2013) Shaowei Wu et al.   JOURNAL OF HAZARDOUS MATERIALS

Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo

(2013) Qi Cao et al.   KIDNEY INTERNATIONAL

Low α2β1 Integrin Function Enhances the Proliferation of Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis by Activation of the β-Catenin Pathway

(2012) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution

(2012) Eric S White et al.   JOURNAL OF PATHOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Protein Phosphatase 2A Regulates Innate Immune and Proteolytic Responses to Cigarette Smoke Exposure in the Lung

(2012) Alison M. Wallace et al.   TOXICOLOGICAL SCIENCES

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice

(2011) D.R. Riva et al.   INHALATION TOXICOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

(2011) Anke Di et al.   NATURE IMMUNOLOGY

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

IL-1: Discoveries, controversies and future directions

(2010) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-10/TGF- -Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis

(2010) Q. Cao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1  Activation in Pancreatic   Cells

(2010) Y. Qiu et al.   Science Signaling

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Moderate Increases in Ambient PM2.5 and Ozone Are Associated With Lung Function Decreases in Beach Lifeguards

(2009) Ephraim I. Thaller et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

The association between fine particulate air pollution and hospital emergency room visits for cardiovascular diseases in Beijing, China

(2009) Yuming Guo et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Dust content of lungs and its relationships to pathology, radiology and occupational exposure in Ontario hardrock miners

(2008) Dave K. Verma et al.   AMERICAN JOURNAL OF INDUSTRIAL MEDICINE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Cationic Amino Acid Transporter-2 Regulates Immunity by Modulating Arginase Activity

(2008) Robert W. Thompson et al.   PLoS Pathogens

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY