Article
Plant Sciences
Rentsen Badamjav, Lu Zhang, Dolgor Sonom, Yun-Hao Wu, Jun-Ping Kou, Bo-Yang Yu, Fang Li
Summary: Thalictrum minus L., a traditional Mongolian folk medicinal plant, demonstrates effectiveness in attenuating particulate matter-induced acute lung injury by modulating inflammatory cytokines and oxidative damage signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Xinlei Zhu, Chen Chen, Bo Zhang, Yihui Ge, Weidong Wang, Jing Cai, Haidong Kan
Summary: By conducting a longitudinal study among 40 healthy adults in Shanghai, China, this research found robust associations of salivary inflammatory markers (e.g., CRP, TNF-alpha) and urinary oxidative stress markers (e.g., 8-iso-PGF(2 alpha)) with short-term PM2.5 exposure. The study identified sub-daily (6-12 hours) and daily (similar to 24 hours) periods as sensitive time windows to detect the responses of salivary and urinary biomarkers, respectively.
Article
Engineering, Environmental
Ziyin Tang, Jeremy A. Sarnat, Rodney J. Weber, Armistead G. Russell, Xiaoyue Zhang, Zhenjiang Li, Tianwei Yu, Dean P. Jones, Donghai Liang
Summary: The study found that particulate oxidative potential may be a key parameter for particulate matter toxicity. By examining the biological changes and underlying molecular mechanisms associated with particulate oxidative potential, the study identified leukotriene metabolism and galactose metabolism in plasma, and vitamin E metabolism and leukotriene metabolism in saliva as top pathways associated with FPMOP. The study also observed different patterns of perturbed pathways for water-soluble and -insoluble FPMOP, and identified five metabolites directly associated with FPMOP. These findings suggest that FPMOP may be a more sensitive and health-relevant measure for understanding the causes related to PM2.5 exposures.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Rongrong Xu, Zhigang Li, Xiaojing Zhu, Chen Guo, Qiaoqiao Su, Jianhao Peng, Zhanshan Wang, Yan Qian, Xiaoqian Li, Qiujin Xu, Yongjie Wei
Summary: This study aimed to investigate the effects of PM2.5 and ozone on lung function, inflammation, and oxidative stress in healthy young adults. The findings indicated that short-term exposure to PM2.5 may decrease lung function and induce inflammation and oxidative stress in healthy adults, but no significant association was found between ozone exposure and these health indicators.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Amanda Garcia, Eduarda Santa-Helena, Anna De Falco, Joaquim de Paula Ribeiro, Adriana Gioda, Carolina Rosa Gioda
Summary: This review examined the toxic effects of PM2.5 particles on human health from 2016 to 2021, finding an increased risk of cardiovascular and respiratory diseases, as well as a correlation with higher morbidity and mortality rates. The study also assessed the interaction between PM2.5 and COVID-19/Sars-CoV-2.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Plant Sciences
Kai Zhao, Xuetong Li, Jingru Yang, Zebin Huang, Chunlian Li, Huarong Huang, Kun Zhang, Dongli Li, Lanyue Zhang, Xi Zheng
Summary: This study investigated the protective effects of Amomum Roxb. essential oils (AEOs) against acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice. The findings revealed that AEOs ameliorated inflammation and oxidative stress through the TLR4/Myd88/NF-Kappa B pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bowen Yin, Jingyi Ren, Qiqi Cui, Xuanyi Liu, Ziyi Wang, Huanting Pei, Jinshi Zuo, Yadong Zhang, Rui Wen, Xiaoya Sun, Weican Zhang, Yuxia Ma
Summary: ASX preconditioning can alleviate lung injury after PM2.5 exposure by inhibiting ferroptosis and apoptosis.
Article
Environmental Sciences
Jie Song, Zhen An, Jingfang Zhu, Juan Li, Rongrong Qu, Ge Tian, Gui Wang, Yange Zhang, Huijun Li, Jing Jiang, Hui Wu, Yinbiao Wang, Weidong Wu
Summary: This longitudinal study conducted in Xinxiang, China, with 61 healthy young volunteers, investigated the acute subclinical cardiovascular effects of PM2.5 and its constituents. The findings revealed that short-term exposure to PM2.5 induced oxidative stress, systemic inflammation, autonomic alterations, and fibrinolysis in healthy young subjects. Nickel content was positively associated with oxidative stress, while other metal components were negatively associated with oxidative stress and heart rate. Additionally, subjects with sufficient GST were more susceptible to autonomic alterations induced by PM2.5.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agriculture, Dairy & Animal Science
Zilin Zhou, Dan Shen, Kai Wang, Junze Liu, Mingyang Li, Tin-Tin Win-Shwe, Kentaro Nagaoka, Chunmei Li
Summary: Fine particulate matter (PM2.5) released during the livestock industry endangers the respiratory health of animals. This study investigated the role of the pulmonary microbiota in the pathogenesis of PM2.5-induced lung inflammation. The results showed that the pulmonary microbiota can affect PM2.5-induced lung inflammation in broilers.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Engineering, Environmental
Caixia Guo, Songqing Lv, Yufan Liu, Yanbo Li
Summary: Epidemiological evidence shows a positive correlation between atmospheric particulate matter (PM2.5) exposure and respiratory diseases, with biomarkers potentially helping to understand the biological mechanisms underlying adverse health outcomes of PM2.5. Inconsistent findings across studies may stem from differences in airborne PM2.5 samples, exposure modes, and methodological issues, warranting further research to identify novel biomarkers and elucidate the causal relationship between PM2.5 pollution and deleterious lung outcomes.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Environmental Sciences
Chiara Macchi, Cesare R. Sirtori, Alberto Corsini, Pier Mannuccio Mannucci, Massimiliano Ruscica
Summary: According to the WHO, the entire global population is exposed to air pollution levels higher than recommended for health preservation. Air pollution, a complex mixture of particles and gases, poses a major global threat to public health. Particulate matter PM2.5 has been identified as a causal factor for cardiovascular diseases such as hypertension, coronary artery disease, stroke, heart failure, arrhythmias, and cardiovascular mortality. This review explores the proatherogenic effects of PM2.5, including endothelial dysfunction, chronic inflammation, reactive oxygen species, mitochondrial dysfunction, and arterial plaque instability.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Immunology
Li Liu, Qiangqiang Shi, Kankai Wang, Yao Qian, Liqin Zhou, Saverio Bellusci, Chengshui Chen, Nian Dong
Summary: FGF10 protects against PM-induced lung injury by activating the PI3K/Akt/Nrf2 pathway, thereby alleviating oxidative damage and pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Kook Lee, Hyo Dam Kim, Suk Hee Lee, Jin Hyup Lee
Summary: This study investigates the protective ability of curcumin against PM-induced pulmonary inflammation. Experimental evidence shows that oxidative stress-mediated inflammation in macrophages is the main pathological outcome of PM exposure. Curcumin alleviates alveolar damage, reduces immune cell infiltration, and suppresses proinflammatory cytokine production in both lung tissue and BALF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu-Chen Jiang, Xin Han, Jia-Yi Dou, Ming-Hui Yuan, Mei-Jie Zhou, Zhen-Yu Cui, Li-Hua Lian, Ji-Xing Nan, Xian Zhang, Yan-Ling Wu
Summary: Siberian onions (SOs) are delicious wild vegetables with unique taste and medicinal properties. This study reveals that SOs can alleviate hepatic fibrogenesis, apoptosis, and inflammation in liver dysfunction by inhibiting the STAT3 signaling pathway.
Article
Environmental Sciences
Peiyu Zhu, Wenfen Zhang, Feifei Feng, Luwei Qin, Wangquan Ji, Dong Li, Ruonan Liang, Yu Zhang, Yuexia Wang, Mengyuan Li, Weidong Wu, Yuefei Jin, Guangcai Duan
Summary: The loss of angiotensin-converting enzyme (ACE)2 exacerbates PM2.5-induced acute lung injury in mice, leading to increased pathology and activation of inflammatory signaling.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Liying Song, Kun Pan, Xihao Du, Shuo Jiang, Xuejiao Zeng, Jia Zhang, Lei Lei, Mengdi Zhang, Yuwen Zhang, Dongxia Fan, Zhixiu Liu, Ji Zhou, Jinzhuo Zhao
Summary: The experiment demonstrated that exposure to PM2.5 can lead to changes in neurobehavior and brain structure in mice, affecting learning and memory abilities; a decrease in albumin and SOD in serum may be related to neural damage; exposure to PM2.5 may activate the PI3K/AKT/FoxO1 pathway, resulting in brain injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Environmental
Xihao Du, Qingli Zhang, Yixuan Jiang, Huichu Li, Xinlei Zhu, Yang Zhang, Cong Liu, Yue Niu, John Ji, Chao Jiang, Jing Cai, Renjie Chen, Haidong Kan
Summary: The study conducted a randomized, crossover trial among healthy young students in Shanghai, China to investigate the biological mechanism of adverse health outcomes related to traffic-related air pollution (TRAP). The multi-omics analysis showed that exposure to TRAP is associated with changes in genome-wide transcription, protein, and metabolite profiles, affecting pathways such as inflammation, oxidative stress, and hormone signaling. The study demonstrated novel pathways activated in response to TRAP exposure, providing evidence of global molecular changes at the multi-omics level.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Cuiping Wang, Jingyu Lin, Yue Niu, Weidong Wang, Jianfen Wen, Lili Lv, Cong Liu, Xihao Du, Qingli Zhang, Bo Chen, Jing Cai, Zhuohui Zhao, Donghai Liang, John S. Ji, Honglei Chen, Renjie Chen, Haidong Kan
Summary: The study revealed that acute ozone exposure can lead to an imbalance in the autonomic nervous system (ANS) and an increase in the secretion of neuroendocrine stress hormones, potentially resulting in adverse cardiometabolic effects.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Xihao Du, Yue Niu, Cuiping Wang, Weidong Wang, Cong Liu, Xia Meng, Chen Chu, Renjie Chen, Haidong Kan
Summary: This study used RNA sequencing technology to explore the impact of acute ozone exposure on the circulating transcriptome. The results showed significant changes in 1899 genes, involving various biological processes and pathways, providing new insights into the systemic health effects of ozone.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Engineering, Environmental
Yue Niu, Huichu Li, Weidong Wang, Cuiping Wang, Cong Liu, Xihao Du, Qingli Zhang, Jingguang Li, Su Shi, Xia Meng, Renjie Chen, Haidong Kan
Summary: This study conducted a proteomic analysis to investigate the impact of ozone exposure on healthy young adults. The results showed that ozone exposure could increase blood coagulation factors and platelet activation, while decreasing some proteins. In addition, ozone exposure was found to be associated with lipid metabolism and immune response.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Endocrinology & Metabolism
Jia-Ran Lin, Zi-Ting Wang, Jiao-Jiao Sun, Ying-Ying Yang, Xue-Xin Li, Xin-Ru Wang, Yue Shi, Yuan-Yuan Zhu, Rui-Ting Wang, Mi-Na Wang, Fei-Yu Xie, Peng Wei, Ze-Huan Liao
Summary: This article summarizes the importance of diabetic kidney disease (DKD) and highlights the role of gut microbiota in the onset and progression of DKD. The authors point out that metabolites of gut microbiota play a key role in microbial-host crosstalk and discuss strategies to remodel gut microbiota as a potential therapeutic target for DKD.
WORLD JOURNAL OF DIABETES
(2022)
Article
Engineering, Environmental
Qingli Zhang, Xihao Du, Huichu Li, Yixuan Jiang, Xinlei Zhu, Yang Zhang, Yue Niu, Cong Liu, John Ji, Steven N. Chillrud, Jing Cai, Renjie Chen, Haidong Kan
Summary: This study systematically investigated the cardiovascular effects of traffic-related air pollution (TRAP). The results showed that exposure to TRAP led to elevated blood pressure, decreased heart rate variability, and molecular alterations associated with systemic inflammation, oxidative stress, endothelial dysfunction, coagulation, and lipid metabolism. The findings provide important mechanistic insights into the cardiovascular effects of TRAP and have implications for TRAP control.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Xihao Du, Qingli Zhang, Yixuan Jiang, Xinlei Zhu, Yang Zhang, Cong Liu, Yue Niu, Jing Cai, Renjie Chen, Haidong Kan
Summary: This study characterized the genome-wide changes of exosomal miRNA associated with TRAP exposure for the first time, providing useful molecular profiling and novel associations for understanding the adverse effects of TRAP.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Jiajia Zhang, Yingying Yang, Zahraa S. Al-Ahmady, Wenchong Du, Jinjin Duan, Zehuan Liao, Qinghua Sun, Zhiyun Wei, Jing Hua
Summary: This study aimed to investigate the effects of maternal exposure to PM2.5 on offspring cognitive function and the underlying mechanisms. The results showed that high levels of PM2.5 exposure during pregnancy were associated with reduced spatial memory in offspring mice and decreased cerebellar microglia, leading to inflammatory damage and oxidative stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Yingying Yang, Tingting Yang, Ji Zhou, Zhijuan Cao, Zehuan Liao, Yan Zhao, Xiujuan Su, Jia He, Jing Hua
Summary: Exposure to ambient fine particulate matter (PM2.5) during pregnancy could lead to adverse birth outcomes, including neurobehavioral development defects. This study investigates the effects and underlying epigenetic mechanisms of maternal concentrated ambient PM2.5 exposure in male mice offspring with spatial memory defects. Results show that prenatal exposure to PM2.5 induces long-lasting spatial memory defects in male mice offspring, potentially mediated by an inflammatory reaction regulated by DNA methylation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Xihao Du, Yixuan Jiang, Huichu Li, Qingli Zhang, Xinlei Zhu, Lu Zhou, Weidong Wang, Yang Zhang, Cong Liu, Yue Niu, Chen Chu, Jing Cai, Renjie Chen, Haidong Kan
Summary: This study explored the association between traffic-related air pollution (TRAP) exposure and genome-wide DNA methylation. The results showed that TRAP exposure led to significant changes in methylation levels of dozens of genes related to cardiometabolic health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Xihao Du, Yixuan Jiang, Qingli Zhang, Xinlei Zhu, Yang Zhang, Cong Liu, Yue Niu, Jing Cai, Haidong Kan, Renjie Chen
Summary: This study aimed to investigate the effects of air pollution on human exosomal long noncoding RNA (lncRNA). A randomized trial was conducted among 35 healthy adults, revealing changes in lncRNA associated with air pollution exposure. These changes were found to be involved in various biological processes, such as cardiovascular signaling, epithelial cell proliferation, inflammation, and transforming growth factor.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Oncology
Wei Li, Yingying Yang, Menghang Yang, Nan Song, Ziwei Wan, Qing Lu, Jingyun Shi
Summary: This study analyzed the clinicopathologic, radiologic, and prognostic characteristics of primary lung mucinous adenocarcinomas (LMAs) based on radiologic classification. Patients with pure-solid and part-solid types had good prognoses, while those with pneumonic type had poor prognoses.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Yingying Yang, Zhen Li, Keyi Si, Qingqiang Dai, Yingying Qiao, Dazhuang Li, Li Zhang, Fan Wu, Jia He, Guizhu Wu
Summary: This study aimed to evaluate the clinical benefits of laparoscopic pectopexy versus laparoscopic sacrocolpopexy in women with pelvic organ prolapse (POP). The results showed similar anatomic success, shorter operation time, and better improvement in quality of life scores for pectopexy compared to sacrocolpopexy. However, pectopexy had a higher risk of urinary symptoms recurrence.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Yu-ting Shen, Ying-ying Yang, Ping-gui Zhang, La-man He, Rong-hua Che, Zhen Li, Wen Lu
Summary: This study investigates the association between different treatments for tubal ectopic pregnancy and subsequent reproductive outcomes. The recommended surgery group had worse outcomes, and the disease status of EP may play a significant role in this association.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
