ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential

(2022) Jianwei Qu et al.   Journal of Hematology & Oncology

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

(2021) Paz Nombela et al.   Molecular Cancer

The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance

(2021) Qing Lan et al.   CANCER RESEARCH

Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

(2021) Liyun Luo et al.   Nature Communications

N6-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression

(2021) Pengxiang Chen et al.   ONCOGENE

ALKBH5 Facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to Generate an Immunosuppressive Tumor Microenvironment

(2021) Feng Dong et al.   CANCER RESEARCH

N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability

(2020) Zhiyuan Zhu et al.   GENE

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

(2020) Chao Shen et al.   Cell Stem Cell

RNA m 6 A methylation regulates sorafenib resistance in liver cancer through FOXO 3‐mediated autophagy

(2020) Ziyou Lin et al.   EMBO JOURNAL

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

(2020) Xingya Guo et al.   Molecular Cancer

N6-methyladenosine regulates glycolysis of cancer cells through PDK4

(2020) Zihan Li et al.   Nature Communications

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

(2020) Na Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways

(2020) Jiadong Liu et al.   Cell Reports

ALKBH5 inhibited cell proliferation and sensitized bladder cancer cells to cisplatin by m6A-CK2α mediated glycolysis

(2020) Hao Yu et al.   Molecular Therapy-Nucleic Acids

N6-methyladenosine RNA modification in cancer therapeutic resistance: Current status and perspectives

(2020) Zhijie Xu et al.   BIOCHEMICAL PHARMACOLOGY

The Critical Role of RNA m6A Methylation in Cancer

(2019) Qing Lan et al.   CANCER RESEARCH

N6-methylation of adenosine (m6A) of FZD10 mRNA contributes to PARP inhibitor resistance

(2019) Takeshi Fukumoto et al.   CANCER RESEARCH

ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2

(2019) Hongtao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Resistance mechanisms to anti-HER2 therapies in HER2-positive breast cancer: Current knowledge, new research directions and therapeutic perspectives

(2019) Claudio Vernieri et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heterogeneity of breast cancer: The importance of interaction between different tumor cell populations

(2019) Indrė Januškevičienė et al.   LIFE SCIENCES

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

(2018) Pierre-Benoit Ancey et al.   FEBS Journal

A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors

(2018) Fei Yan et al.   CELL RESEARCH

HER2-positive breast cancer

(2017) Sibylle Loibl et al.   LANCET

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

(2017) Chong Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells

(2016) Chuanzhao Zhang et al.   Oncotarget

In SilicoModeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy

(2015) Rama K. Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells

(2015) Hui Lyu et al.   Oncotarget

Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

(2014) Pablo Garrido et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Glucose transporters in cancer metabolism

(2012) Kehinde Adekola et al.   CURRENT OPINION IN ONCOLOGY

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells

(2012) Kakajan Komurov et al.   Molecular Systems Biology

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

Heterotrimerization of the Growth Factor Receptors erbB2, erbB3, and Insulin-like Growth Factor-I Receptor in Breast Cancer Cells Resistant to Herceptin

(2010) X. Huang et al.   CANCER RESEARCH