Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

(2021) Yansen Xiao et al.   CANCER CELL

Dicer‐independent snRNA/snoRNA‐derived nuclear RNA 3 regulates tumor‐associated macrophage function by epigenetically repressing inducible nitric oxide synthase transcription

(2021) Yang Shi et al.   Cancer Communications

Epigenetic Remodeling in Innate Immunity and Inflammation

(2021) Qian Zhang et al.   Annual Review of Immunology

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

(2021) Gabriel K. Griffin et al.   NATURE

A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism

(2021) Pratik Shriwas et al.   Cancer & Metabolism

Krebs Cycle Reborn in Macrophage Immunometabolism

(2020) Dylan G. Ryan et al.   Annual Review of Immunology

Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

(2020) Elie Dheilly et al.   CANCER CELL

Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG

(2019) Yan Gu et al.   NATURE MEDICINE

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis

(2019) Juan Liu et al.   IMMUNITY

Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses

(2019) Fanghui Zhang et al.   IMMUNITY

Dual blockade of CXCL12-CXCR4 and PD-1–PD-L1 pathways prolongs survival of ovarian tumor–bearing mice by prevention of immunosuppression in the tumor microenvironment

(2019) Yang Zeng et al.   FASEB JOURNAL

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

(2019) Xinghui Li et al.   IMMUNITY

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

(2019) Chang Liu et al.   IMMUNITY

MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses

(2019) Nan Song et al.   Cell Reports

Aerobic glycolysis is a metabolic requirement to maintain the M2-like polarization of tumor-associated macrophages

(2019) Natália M. de-Brito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

(2018) Tina Cascone et al.   Cell Metabolism

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

(2018) Wei Li et al.   Cell Metabolism

Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

(2018) Qicong Shen et al.   NATURE

Bias, robustness and scalability in single-cell differential expression analysis

(2018) Charlotte Soneson et al.   NATURE METHODS

Enhanced Transdermal Drug Delivery by Transfersome-Embedded Oligopeptide Hydrogel for Topical Chemotherapy of Melanoma

(2018) Tianyue Jiang et al.   ACS Nano

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

(2018) Feilong Wang et al.   Cell Metabolism

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

(2018) Tianliang Li et al.   Cell Host & Microbe

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation

(2017) Xinghui Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment

(2016) Di Liu et al.   JOURNAL OF PROTEOME RESEARCH

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

The nutrient sensor OGT in PVN neurons regulates feeding

(2016) O. Lagerlof et al.   SCIENCE

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages

(2016) Rob J. W. Arts et al.   OncoImmunology

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

(2016) Hweixian Leong Penny et al.   OncoImmunology

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

The Roles of Lysosomes in Inflammation and Autoimmune Diseases

(2014) Wei Ge et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsins Limit Macrophage Necroptosis through Cleavage of Rip1 Kinase

(2014) S. McComb et al.   JOURNAL OF IMMUNOLOGY

Cathepsin B: Multiple roles in cancer

(2014) Neha Aggarwal et al.   Proteomics Clinical Applications

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

Alternative activation of tumor-associated macrophages by IL-4

(2011) Hao-Wei Wang et al.   CELL CYCLE

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

Impaired turnover of autophagolysosomes in cathepsin L deficiency

(2010) Julia Dennemärker et al.   BIOLOGICAL CHEMISTRY

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Late Endosome/Lysosome-Localized Rab7b Suppresses TLR9-Initiated Proinflammatory Cytokine and Type I IFN Production in Macrophages

(2009) M. Yao et al.   JOURNAL OF IMMUNOLOGY

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130

(2008) Y. Tanaka et al.   MOLECULAR AND CELLULAR BIOLOGY