Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

(2022) J. Joseph Melenhorst et al.   NATURE

Enhanced Chimeric Antigen Receptor T Cell Therapy through Co-Application of Synergistic Combination Partners

(2022) Sophia Stock et al.   Biomedicines

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours

(2022) Rebecca C. Larson et al.   NATURE

A modular and controllable T cell therapy platform for acute myeloid leukemia

(2021) Mohamed-Reda Benmebarek et al.   LEUKEMIA

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

(2021) Lauren Giuffrida et al.   Nature Communications

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

(2021) Bruno L. Cadilha et al.   Science Advances

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

(2021) Stefanie Lesch et al.   Nature Biomedical Engineering

ARC-4 study: Efficacy and safety of AB928 plus carboplatin, pemetrexed and a PD-1 antibody in participants with metastatic non-small cell lung cancer (mNSCLC).

(2020) Alexander I. Spira et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

(2020) Elham Masoumi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Expression of Adenosine A2B Receptor on Antigen-Presenting Cells Suppresses CD8+ T-cell Responses and Promotes Tumor Growth

(2020) Siqi Chen et al.   Cancer Immunology Research

Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

(2020) David Y. Oh et al.   CELL

Pharmacological targeting of immune checkpoint A2aR improves function of anti-CD19 CAR T cells in vitro

(2020) Keyvan Fallah-Mehrjardi et al.   IMMUNOLOGY LETTERS

The adenosine pathway in immuno-oncology

(2020) Bertrand Allard et al.   Nature Reviews Clinical Oncology

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

(2019) Mohamed-Reda Benmebarek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhancing tumor T cell infiltration to enable cancer immunotherapy

(2019) Jin Zhang et al.   Immunotherapy

Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy

(2019) Stefan Stoiber et al.   Cells

Bispecific antibodies enable synthetic agonistic receptor-transduced T cells for tumor immunotherapy

(2019) Clara Helke Karches et al.   CLINICAL CANCER RESEARCH

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

(2019) Selena Vigano et al.   Frontiers in Immunology

1206PPhase I evaluation of AB928, a novel dual adenosine receptor antagonist, combined with chemotherapy or AB122 (anti-PD-1) in patients (pts) with advanced malignancies

(2019) J Powderly et al.   ANNALS OF ONCOLOGY

Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors

(2019) Rachel Grosser et al.   CANCER CELL

Determinants of response and resistance to CAR T cell therapy

(2019) Stefanie Lesch et al.   SEMINARS IN CANCER BIOLOGY

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

Small Molecules Drive Big Improvements in Immuno-Oncology Therapies

(2018) Bayard R. Huck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

(2018) Robert D. Leone et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A2AAdenosine Receptor Gene Deletion or Synthetic A2AAntagonist Liberate Tumor-Reactive CD8+T Cells from Tumor-Induced Immunosuppression

(2018) Jorgen Kjaergaard et al.   JOURNAL OF IMMUNOLOGY

Impact of target interactions on small-molecule drug disposition: an overlooked area

(2018) Robert A. B. van Waterschoot et al.   NATURE REVIEWS DRUG DISCOVERY

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors

(2018) Sonja Hinz et al.   Oncotarget

Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers

(2018) Lisa Seitz et al.   INVESTIGATIONAL NEW DRUGS

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

(2017) Paul A. Beavis et al.   JOURNAL OF CLINICAL INVESTIGATION

Durable Molecular Remissions in Chronic Lymphocytic Leukemia Treated With CD19-Specific Chimeric Antigen Receptor–Modified T Cells After Failure of Ibrutinib

(2017) Cameron J. Turtle et al.   JOURNAL OF CLINICAL ONCOLOGY

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer cells induce interleukin-22 production from memory CD4+T cells via interleukin-1 to promote tumor growth

(2017) Cornelia Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity

(2016) Caroline Baer et al.   NATURE CELL BIOLOGY

Chimeric antigen receptor T-cell therapy for solid tumors

(2016) Kheng Newick et al.   Molecular Therapy-Oncolytics

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

Impact of a New Fusion Receptor on PD-1–Mediated Immunosuppression in Adoptive T Cell Therapy

(2015) Sebastian Kobold et al.   JNCI-Journal of the National Cancer Institute

Impact of a New Fusion Receptor on PD-1–Mediated Immunosuppression in Adoptive T Cell Therapy

(2015) Sebastian Kobold et al.   JNCI-Journal of the National Cancer Institute

C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer

(2015) Moritz Rapp et al.   OncoImmunology

Host A2B Adenosine Receptors Promote Carcinoma Growth

(2015) Sergey Ryzhov et al.   NEOPLASIA

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma

(2015) Raffaella Iannone et al.   NEOPLASIA

Adenosine Receptors: Expression, Function and Regulation

(2014) Sandeep Sheth et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of TGF-β Signaling in Generation of CD39+CD73+Myeloid Cells in Tumors

(2014) Sergey V. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

Selective Bispecific T Cell Recruiting Antibody and Antitumor Activity of Adoptive T Cell Transfer

(2014) Sebastian Kobold et al.   JNCI-Journal of the National Cancer Institute

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

Adenosine A2B receptor antagonist suppresses differentiation to regulatory T cells without suppressing activation of T cells

(2011) Hiroko Nakatsukasa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vivo Inhibition of Human CD19-Targeted Effector T Cells by Natural T Regulatory Cells in a Xenotransplant Murine Model of B Cell Malignancy

(2011) J. C. Lee et al.   CANCER RESEARCH

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

Recent developments in adenosine receptor ligands and their potential as novel drugs

(2010) Christa E. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes

(2010) R. Bos et al.   CANCER RESEARCH

Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis

(2010) Dana Briesemeister et al.   INTERNATIONAL JOURNAL OF CANCER

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

(2009) William D. Hastings et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Efficient Human Hematopoietic Cell Transduction Using RD114- and GALV-Pseudotyped Retroviral Vectors Produced in Suspension and Serum-Free Media

(2009) Karim Ghani et al.   HUMAN GENE THERAPY

Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling

(2009) Carsten Linnemann et al.   IMMUNOLOGY

IFN-γ– and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers

(2008) Bin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

(2008) Patrizia Pellegatti et al.   PLoS One