CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours

Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

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Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation

(2021) Enrique J. Arenas et al.   Nature Communications

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

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Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction

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KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

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Tuning the Antigen Density Requirement for CAR T-cell Activity

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Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR

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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus

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Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

(2020) Keith A. Lawson et al.   NATURE

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

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Low-dose IFN-γ induces tumor cell stemness in the tumor microenvironment of non-small cell lung cancer

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B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

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Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity

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Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma

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CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges

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Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

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A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

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EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma

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Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial

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Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

(2018) Kendall R. Sanson et al.   Nature Communications

Making CAR T Cells a Solid Option for Solid Tumors

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Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase

(2017) Alec J. Walker et al.   MOLECULAR THERAPY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Identification of essential genes for cancer immunotherapy

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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

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Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

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Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

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Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

(2016) Christine E. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

(2016) Anne-Elisabeth Petit et al.   Nature Communications

Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

(2015) X. Liu et al.   CANCER RESEARCH

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

(2015) Laura A. Johnson et al.   Science Translational Medicine

Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells

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B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma

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Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

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