The central role of tau in Alzheimer’s disease: From neurofibrillary tangle maturation to the induction of cell death

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic C. elegans

(2022) Caitlin S. Latimer et al.   Disease Models & Mechanisms

Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels

(2022) Malin Wennström et al.   Acta Neuropathologica Communications

Alzheimer disease neuropathology in a patient previously treated with aducanumab

(2022) Edward D. Plowey et al.   ACTA NEUROPATHOLOGICA

Antemortem plasma phosphorylated tau (181) predicts Alzheimer’s disease neuropathology and regional tau at autopsy

(2022) Madeline S. Morrison et al.   BRAIN

Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation

(2022) Seong Su Kang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regional Aβ-tau interactions promote onset and acceleration of Alzheimer’s disease tau spreading

(2022) Wha Jin Lee et al.   NEURON

Importance of the locus coeruleus-norepinephrine system in sleep-wake regulation: Implications for aging and Alzheimer's disease

(2022) Maxime Van Egroo et al.   SLEEP MEDICINE REVIEWS

Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease

(2022) Yue Dong et al.   Journal of Neuroinflammation

Association of Cognition and Dementia With Neuropathologic Changes of Alzheimer Disease and Other Conditions in the Oldest-Old

(2022) Thomas J. Montine et al.   NEUROLOGY

Alzheimer's disease failed clinical trials

(2022) Shreya Asher et al.   LIFE SCIENCES

Divergent magnetic resonance imaging atrophy patterns in Alzheimer's disease and primary age-related tauopathy

(2022) Miguel Quintas-Neves et al.   NEUROBIOLOGY OF AGING

LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease

(2022) Marta J. Koper et al.   Acta Neuropathologica Communications

Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation

(2021) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

Interplay between tau and α‐synuclein LLPS

(2021) Anna Siegert et al.   PROTEIN SCIENCE

TDP-43 interacts with pathological τ protein in Alzheimer’s disease

(2021) Sandra O. Tomé et al.   ACTA NEUROPATHOLOGICA

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research

(2021) Christina M. Moloney et al.   Alzheimers & Dementia

Co-pathologies in Alzheimer’s disease: just multiple pathologies or partners in crime?

(2021) Sandra O Tomé et al.   BRAIN

Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study

(2021) Elisabeth H Thijssen et al.   LANCET NEUROLOGY

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

(2021) Yuxing Xia et al.   Molecular Neurodegeneration

Can we learn lessons from the FDA’s approval of aducanumab?

(2021) Kathy Y. Liu et al.   Nature Reviews Neurology

Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets

(2021) Vincent Breton-Provencher et al.   Frontiers in Neural Circuits

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study

(2021) Megan A. Iida et al.   Acta Neuropathologica Communications

Genome-wide association study and functional validation implicates JADE1 in tauopathy

(2021) Kurt Farrell et al.   ACTA NEUROPATHOLOGICA

Cryo-EM structures of τ filaments from human brain

(2021) Michel Goedert   Essays in Biochemistry

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

(2021) Giovanni B. Frisoni et al.   NATURE REVIEWS NEUROSCIENCE

Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia

(2020) Shorena Janelidze et al.   NATURE MEDICINE

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

(2020) Na Zhao et al.   Science Translational Medicine

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

(2020) Thomas K Karikari et al.   LANCET NEUROLOGY

Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes

(2020) Adam S. Fleisher et al.   JAMA Neurology

Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes

(2020) Sandra O. Tomé et al.   Acta Neuropathologica Communications

Plasma p-tau181 accurately predicts Alzheimer’s disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline

(2020) Juan Lantero Rodriguez et al.   ACTA NEUROPATHOLOGICA

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), ADNC Pathology, and Cognitive Decline in Aging

(2020) Alifiya Kapasi et al.   NEUROLOGY

Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer’s disease pathology: a clinicopathological study

(2020) Michael J. Pontecorvo et al.   EJNMMI Research

α-Synuclein modulates tau spreading in mouse brains

(2020) Fares Bassil et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Necrosome‐positive granulovacuolar degeneration is associated with TDP‐43 pathological lesions in the hippocampus of ALS/FTLD cases

(2020) E. Van Schoor et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Plasma Phospho‐Tau Identifies Alzheimer's Co‐Pathology in Patients with Lewy Body Disease

(2020) Sara Hall et al.   MOVEMENT DISORDERS

Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

(2019) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Clinical diagnoses among individuals with primary age-related tauopathy versus Alzheimer’s neuropathology

(2019) Merilee Teylan et al.   LABORATORY INVESTIGATION

Tau interacts with the C-terminal region of α-synuclein, promoting formation of toxic aggregates with distinct molecular conformations

(2019) Anvesh K. R. Dasari et al.   BIOCHEMISTRY

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

α-synuclein in the pathophysiology of Alzheimer’s disease

(2019) Daniel Twohig et al.   Molecular Neurodegeneration

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

(2019) Caitlin S. Latimer et al.   Acta Neuropathologica Communications

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

(2019) Vera I. Wiersma et al.   ACTA NEUROPATHOLOGICA

Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein

(2019) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

(2019) Dietmar Rudolf Thal et al.   Acta Neuropathologica Communications

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

(2019) Marta J. Koper et al.   ACTA NEUROPATHOLOGICA

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

(2019) Grant T. Corbett et al.   ACTA NEUROPATHOLOGICA

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

(2018) Sarah K. Kaufman et al.   ACTA NEUROPATHOLOGICA

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease

(2018) Min Shi et al.   Alzheimers & Dementia

Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn

(2018) Chuanzhou Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau

(2018) Karishma Bhasne et al.   JOURNAL OF MOLECULAR BIOLOGY

Estimation of amyloid distribution by [18F]flutemetamol PET predicts the neuropathological phase of amyloid β-protein deposition

(2018) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Altered CSF Orexin and α-Synuclein Levels in Dementia Patients

(2018) Malin Wennström et al.   JOURNAL OF ALZHEIMERS DISEASE

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

(2018) Renaud La Joie et al.   Alzheimers & Dementia

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β Induced Synaptic Dysfunction and Loss

(2018) Santiago V. Salazar et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of serine 305 in tau inhibits aggregation

(2018) Kevin H. Strang et al.   NEUROSCIENCE LETTERS

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

(2018) Sílvia Porta et al.   Nature Communications

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

(2018) Daniel Twohig et al.   Acta Neuropathologica Communications

Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies

(2017) Jianlan Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study

(2017) Keith A Josephs et al.   LANCET NEUROLOGY

Phosphoregulation of Tau modulates inhibition of kinesin-1 motility

(2017) Jamie L. Stern et al.   MOLECULAR BIOLOGY OF THE CELL

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Necroptosis activation in Alzheimer's disease

(2017) Antonella Caccamo et al.   NATURE NEUROSCIENCE

TDP-43 expression influences amyloidβ plaque deposition and tau aggregation

(2017) Stephani A. Davis et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity

(2016) Sathish Kumar et al.   ACTA NEUROPATHOLOGICA

Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology

(2016) Christoph Köhler   ACTA NEUROPATHOLOGICA

Regional profiles of the candidate tau PET ligand18F-AV-1451 recapitulate key features of Braak histopathological stages

(2016) Adam J. Schwarz et al.   BRAIN

TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing

(2016) Kirsty E. McAleese et al.   BRAIN PATHOLOGY

APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice

(2016) Meng Zhou et al.   Current Alzheimer Research

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly

(2016) Takayuki Oikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Protein aggregation in Alzheimer’s disease: Aβ and τ and their potential roles in the pathogenesis of AD

(2015) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

(2015) Michiyo Iba et al.   ACTA NEUROPATHOLOGICA

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

(2015) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

(2015) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology

(2015) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

TDP-43 is intercellularly transmitted across axon terminals

(2015) Marisa S. Feiler et al.   JOURNAL OF CELL BIOLOGY

The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase

(2015) Agnese De Mario et al.   Frontiers in Cellular Neuroscience

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

(2015) Sara Calafate et al.   Cell Reports

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Transport and diffusion of Tau protein in neurons

(2014) Tim Scholz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis

(2014) Christoph Köhler et al.   NEUROBIOLOGY OF DISEASE

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

(2014) Magdalena Gąssowska et al.   PLoS One

Alzheimer’s Amyloid-β Oligomers Rescue Cellular Prion Protein Induced Tau Reduction via the Fyn Pathway

(2013) Rong-Jie Chen et al.   ACS Chemical Neuroscience

Cerebral amyloid PET imaging in Alzheimer’s disease

(2013) Clifford R. Jack et al.   ACTA NEUROPATHOLOGICA

Changes in tau phosphorylation in hibernating rodents

(2013) Gonzalo León-Espinosa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress response

(2011) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson’s disease

(2011) Thomas Haggerty et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Tangle evolution linked to differential 3- and 4-repeat tau isoform deposition: a double immunofluorolabeling study using two monoclonal antibodies

(2011) Toshiki Uchihara et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

Correlations between cortical and subcortical tau pathology

(2011) J. Attems et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer’s disease

(2010) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles

(2010) K. E. Funk et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transactive Response DNA-Binding Protein 43 Burden in Familial Alzheimer Disease and Down Syndrome

(2009) Carol F. Lippa et al.   ARCHIVES OF NEUROLOGY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration

(2009) Ai Kadokura et al.   NEUROSCIENCE LETTERS

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

(2008) Brit Mollenhauer et al.   EXPERIMENTAL NEUROLOGY