Calycosin modulates NLRP3 and TXNIP-mediated pyroptotic signaling and attenuates diabetic nephropathy progression in diabetic rats; An insight

Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis

(2022) Di Huang et al.   PHARMACEUTICAL BIOLOGY

The Leukotriene Receptor Antagonist Montelukast as a Potential COVID-19 Therapeutic

(2021) Ludwig Aigner et al.   Frontiers in Molecular Biosciences

The protective effects of calycosin against diabetic nephropathy through Sirt3/SOD2/caspase-3 signaling pathway: In vitro

(2021) Ruifeng Jiang et al.   Arabian Journal of Chemistry

Calycosin Influences the Metabolism of Five Probe Drugs in Rats

(2020) Mei-ling Wu et al.   Drug Design Development and Therapy

Inflammatory Targets in Diabetic Nephropathy

(2020) Javier Donate-Correa et al.   Journal of Clinical Medicine

Positive interaction of mangiferin with selected oral hypoglycemic drugs: a therapeutic strategy to alleviate diabetic nephropathy in experimental rats

(2020) Vidhushini Sekar et al.   MOLECULAR BIOLOGY REPORTS

The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression

(2020) Yuan Li et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Calycosin Ameliorates Diabetes-Induced Renal Inflammation via the NF-κB Pathway In Vitro and In Vivo

(2019) Ying-ying Zhang et al.   MEDICAL SCIENCE MONITOR

Long noncoding RNA KCNQ1OT1 induces pyroptosis in diabetic corneal endothelial keratopathy.

(2019) Yanyan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression

(2019) Nehal M. Elsherbiny et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

Endogenous non-enzymatic antioxidants in the human body

(2018) Iwona Mirończuk-Chodakowska et al.   Advances in Medical Sciences

Update on Diabetic Nephropathy: Core Curriculum 2018

(2018) Kausik Umanath et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats

(2018) Hadeer O. Abou-Hany et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Diabetic nephropathy: Is there a role for oxidative stress?

(2018) Manpreet K. Sagoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Crosstalk between Nrf2 and Inflammasomes

(2018) Paulina Hennig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome

(2018) Tao Ding et al.   PHYTOMEDICINE

Cellular death, reactive oxygen species (ROS) and diabetic complications

(2018) Caroline Maria Oliveira Volpe et al.   Cell Death & Disease

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

(2018) Yachun Han et al.   Redox Biology

Molecular pathways associated with oxidative stress in diabetes mellitus

(2018) Osasenaga Macdonald Ighodaro   BIOMEDICINE & PHARMACOTHERAPY

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

(2018) Ming Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Predicting Diabetes Mellitus With Machine Learning Techniques

(2018) Quan Zou et al.   Frontiers in Genetics

Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic Nephropathy

(2017) Zhangjian Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tangshen formula attenuates diabetic renal injuries by upregulating autophagy via inhibition of PLZF expression

(2017) Hailing Zhao et al.   PLoS One

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Resveratrol ameliorates diabetic nephropathy in rats through negative regulation of the p38 MAPK/TGF-β1 pathway

(2017) Yuan Qiao et al.   Experimental and Therapeutic Medicine

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

(2017) Manuel Matzinger et al.   BIOTECHNOLOGY ADVANCES

Diabetes and Kidney Disease: Role of Oxidative Stress

(2016) Jay C. Jha et al.   ANTIOXIDANTS & REDOX SIGNALING

Clinical implications of oxidative stress and potential role of natural antioxidants in diabetic vascular complications

(2016) A. Ceriello et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Danggui Buxue Tang Attenuates Tubulointerstitial Fibrosis via Suppressing NLRP3 Inflammasome in a Rat Model of Unilateral Ureteral Obstruction

(2016) Linna Wang et al.   Biomed Research International

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

Calycosin Rebalances Advanced Glycation End Products-Induced Glucose Uptake Dysfunction of Hepatocyte In Vitro

(2015) Youhua Xu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy

(2015) A. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes

(2015) Gina Manda et al.   MEDIATORS OF INFLAMMATION

Calycosin-7-O-β-d-glucoside attenuates ischemia-reperfusion injury in vivo via activation of the PI3K/Akt pathway

(2015) MIN REN et al.   Molecular Medicine Reports

Innate immunity in diabetes and diabetic nephropathy

(2015) Jun Wada et al.   Nature Reviews Nephrology

Inflammatory Cytokines in Diabetic Nephropathy

(2015) Javier Donate-Correa et al.   Journal of Diabetes Research

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modeling type 2 diabetes in rats using high fat diet and streptozotocin

(2014) Søs Skovsø   Journal of Diabetes Investigation

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases

(2014) Eiji Yoshihara et al.   Frontiers in Immunology

Inflammation and the pathogenesis of diabetic nephropathy

(2012) Jun Wada et al.   CLINICAL SCIENCE

Inflammation in Diabetic Nephropathy

(2012) Andy K. H. Lim et al.   MEDIATORS OF INFLAMMATION

Oral Cavity and Systemic Diseases—Diabetes Mellitus

(2011) Assya Krasteva et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin

(2011) Yumi Takiyama et al.   DIABETES

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

(2011) Juan F. Navarro-González et al.   Nature Reviews Nephrology

Montelukast: More than a Cysteinyl Leukotriene Receptor Antagonist?

(2011) Gregory R. Tintinger et al.   TheScientificWorldJOURNAL

Inhibitory Effects of Two Major Isoflavonoids in Radix Astragali on High Glucose-Induced Mesangial Cells Proliferation and AGEs-Induced Endothelial Cells Apoptosis

(2010) Dan Tang et al.   PLANTA MEDICA

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

(2008) Xiaoqing He et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY