Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing

Bilayered extracellular matrix derived scaffolds with anisotropic pore architecture guide tissue organization during osteochondral defect repair

(2022) David C. Browe et al.   Acta Biomaterialia

3D bioassembly of cell-instructive chondrogenic and osteogenic hydrogel microspheres containing allogeneic stem cells for hybrid biofabrication of osteochondral constructs

(2022) Xiaolin Cui et al.   Biofabrication

Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions in Mild to Moderate Osteoarthritic Knees: Results of a 2-Year Multicenter Prospective Study

(2021) Elizaveta Kon et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues

(2021) Ross Burdis et al.   Acta Biomaterialia

Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo

(2021) Gabriella Nilsson Hall et al.   BIOMATERIALS

Biological resurfacing in a canine model of hip osteoarthritis

(2021) Bradley T. Estes et al.   Science Advances

Biofabrication of Prevascularised Hypertrophic Cartilage Microtissues for Bone Tissue Engineering

(2021) Jessica Nulty et al.   Frontiers in Bioengineering and Biotechnology

Bioprinting of biomimetic self-organised cartilage with a supporting joint fixation device

(2021) Ross Burdis et al.   Biofabrication

Probing Multicellular Tissue Fusion of Cocultured Spheroids—A 3D‐Bioassembly Model

(2021) Gabriella C. J. Lindberg et al.   Advanced Science

Aspiration-assisted bioprinting for precise positioning of biologics

(2020) Bugra Ayan et al.   Science Advances

Cell spheroid fusion: beyond liquid drops model

(2020) Nastasia V. Kosheleva et al.   Scientific Reports

Aspiration-assisted bioprinting of the osteochondral interface

(2020) Bugra Ayan et al.   Scientific Reports

Innovative Tissue‐Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges

(2020) Liangbin Zhou et al.   Advanced Healthcare Materials

A Scaffold-Free Allogeneic Construct From Adipose-Derived Stem Cells Regenerates an Osteochondral Defect in a Rabbit Model

(2019) Takeshi Oshima et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Cell number in mesenchymal stem cell aggregates dictates cell stiffness and chondrogenesis

(2019) Melika Sarem et al.   Stem Cell Research & Therapy

Enhancing Biocompatibility without Compromising Material Properties: An Optimised NaOH Treatment for Electrospun Polycaprolactone Fibres

(2019) Lucy A. Bosworth et al.   Journal of Nanomaterials

Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers

(2019) Andrew C. Daly et al.   BIOMATERIALS

Fibronectin Functionalized Electrospun Fibers by Using Benign Solvents: Best Way to Achieve Effective Functionalization

(2019) Liliana Liverani et al.   Frontiers in Bioengineering and Biotechnology

Characterization of extracellular matrix modified poly(ε-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration

(2019) Julia Fernández-Pérez et al.   Materials Science & Engineering C-Materials for Biological Applications

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

(2019) Gabriella Nilsson Hall et al.   Advanced Science

Biomaterials for articular cartilage tissue engineering: Learning from biology

(2018) A.R. Armiento et al.   Acta Biomaterialia

Osteochondral regeneration using constructs of mesenchymal stem cells made by bio three-dimensional printing in mini-pigs

(2018) Atsushi Yamasaki et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Recapitulation of physiological spatiotemporal signals promotes in vitro formation of phenotypically stable human articular cartilage

(2017) Johnathan J. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Articular cartilage repair: Current needs, methods and research directions

(2017) Diego Correa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Osteochondral Regeneration with a Scaffold-Free Three-Dimensional Construct of Adipose Tissue-Derived Mesenchymal Stromal Cells in Pigs

(2017) Daiki Murata et al.   Tissue Engineering and Regenerative Medicine

Osteochondral Regeneration with a Scaffold-Free Three-Dimensional Construct of Adipose Tissue-Derived Mesenchymal Stromal Cells in Pigs

(2017) Daiki Murata et al.   Tissue Engineering and Regenerative Medicine

Modular Tissue Assembly Strategies for Biofabrication of Engineered Cartilage

(2016) B. S. Schon et al.   ANNALS OF BIOMEDICAL ENGINEERING

Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints

(2016) Tanya J. Levingstone et al.   BIOMATERIALS

Cell-based tissue engineering strategies used in the clinical repair of articular cartilage

(2016) Brian J. Huang et al.   BIOMATERIALS

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering

(2016) Andrew C. Daly et al.   Advanced Healthcare Materials

Tissue engineering strategies to study cartilage development, degeneration and regeneration

(2015) Maumita Bhattacharjee et al.   ADVANCED DRUG DELIVERY REVIEWS

High-throughput bone and cartilage micropellet manufacture, followed by assembly of micropellets into biphasic osteochondral tissue

(2015) Betul Kul Babur et al.   CELL AND TISSUE RESEARCH

Cell-based articular cartilage repair: the link between development and regeneration

(2015) K.L. Caldwell et al.   OSTEOARTHRITIS AND CARTILAGE

An educational review of cartilage repair: precepts & practice – myths & misconceptions – progress & prospects

(2015) E.B. Hunziker et al.   OSTEOARTHRITIS AND CARTILAGE

A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells

(2015) Daiki Murata et al.   Journal of Orthopaedic Surgery and Research

Emergence of Scaffold-Free Approaches for Tissue Engineering Musculoskeletal Cartilages

(2014) Grayson D. DuRaine et al.   ANNALS OF BIOMEDICAL ENGINEERING

Combined use of chondroitinase-ABC, TGF-β1, and collagen crosslinking agent lysyl oxidase to engineer functional neotissues for fibrocartilage repair

(2014) Eleftherios A. Makris et al.   BIOMATERIALS

Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation

(2014) S. Bhumiratana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repairing the Osteochondral Defect in Goat with the Tissue-Engineered Osteochondral Graft Preconstructed in a Double-Chamber Stirring Bioreactor

(2014) Yang Pei et al.   Biomed Research International

Treatment of Knee Osteochondritis Dissecans With a Cell-Free Biomimetic Osteochondral Scaffold

(2013) Giuseppe Filardo et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Self-Organization and the Self-Assembling Process in Tissue Engineering

(2013) Kyriacos A. Athanasiou et al.   Annual Review of Biomedical Engineering

Preparation of an osteochondral composite with mesenchymal stem cells as the single-cell source in a double-chamber bioreactor

(2013) Xing-guo Liu et al.   BIOTECHNOLOGY LETTERS

Three-dimensional scaffold-free fusion culture: the way to enhance chondrogenesis of in vitro propagated human articular chondrocytes

(2013) M. Lehmann et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Engineering of a functional bone organ through endochondral ossification

(2013) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Priming 3D Cultures of Human Mesenchymal Stromal Cells Toward Cartilage Formation Via Developmental Pathways

(2013) Matteo Centola et al.   STEM CELLS AND DEVELOPMENT

Mechanisms underlying the synergistic enhancement of self-assembled neocartilage treated with chondroitinase-ABC and TGF-β1

(2012) Donald J. Responte et al.   BIOMATERIALS

Osteogenic differentiation and osteochondral tissue engineering using human adipose-derived stem cells

(2012) Nastaran Mahmoudifar et al.   BIOTECHNOLOGY PROGRESS

Unlike Bone, Cartilage Regeneration Remains Elusive

(2012) D. J. Huey et al.   SCIENCE

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

(2011) R. Rezakhaniha et al.   Biomechanics and Modeling in Mechanobiology

Evaluation of early-stage osteochondral defect repair using a biphasic scaffold based on a collagen–glycosaminoglycan biopolymer in a caprine model

(2011) Alan M.J. Getgood et al.   KNEE

Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy

(2011) M.E. Cooke et al.   OSTEOARTHRITIS AND CARTILAGE

Membrane Culture of Bone Marrow Stromal Cells Yields Better Tissue Than Pellet Culture for Engineering Cartilage-Bone Substitute Biphasic Constructs in a Two-Step Process

(2011) Whitaik David Lee et al.   TISSUE ENGINEERING PART C-METHODS

A New Histology Scoring System for the Assessment of the Quality of Human Cartilage Repair: ICRS II

(2010) Pierre Mainil-Varlet et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs

(2010) Frank G. Lyons et al.   BIOMATERIALS

Chondrogenic differentiation of human mesenchymal stem cells: a comparison between micromass and pellet culture systems

(2010) Liangming Zhang et al.   BIOTECHNOLOGY LETTERS

The subchondral bone in articular cartilage repair: current problems in the surgical management

(2010) Andreas H. Gomoll et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering

(2010) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coculture of Human Mesenchymal Stem Cells and Articular Chondrocytes Reduces Hypertrophy and Enhances Functional Properties of Engineered Cartilage

(2010) Liming Bian et al.   TISSUE ENGINEERING PART A

Fixation of Tissue-Engineered Human Neocartilage Constructs with Human Fibrin in a Caprine Model

(2010) Paul Lewis et al.   Journal of Knee Surgery

Organ printing: Tissue spheroids as building blocks

(2009) Vladimir Mironov et al.   BIOMATERIALS

Functional properties of cartilaginous tissues engineered from infrapatellar fat pad-derived mesenchymal stem cells

(2009) Conor Timothy Buckley et al.   JOURNAL OF BIOMECHANICS

Effects of multiple chondroitinase ABC applications on tissue engineered articular cartilage

(2009) Roman M. Natoli et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Developmental Engineering: A New Paradigm for the Design and Manufacturing of Cell-Based Products. Part II. From Genes to Networks: Tissue Engineering from the Viewpoint of Systems Biology and Network Science

(2009) Petros Lenas et al.   TISSUE ENGINEERING PART B-REVIEWS

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Bilayered chitosan-based scaffolds for osteochondral tissue engineering: Influence of hydroxyapatite on in vitro cytotoxicity and dynamic bioactivity studies in a specific double-chamber bioreactor

(2008) Patrícia B. Malafaya et al.   Acta Biomaterialia

Systematic assessment of growth factor treatment on biochemical and biomechanical properties of engineered articular cartilage constructs

(2008) B.D. Elder et al.   OSTEOARTHRITIS AND CARTILAGE

Matrix Development in Self-Assembly of Articular Cartilage

(2008) Gidon Ofek et al.   PLoS One

Effects of Temporal Hydrostatic Pressure on Tissue-Engineered Bovine Articular Cartilage Constructs

(2008) Benjamin D. Elder et al.   TISSUE ENGINEERING PART A

Effects of confinement on the mechanical properties of self-assembled articular cartilage constructs in the direction orthogonal to the confinement surface

(2007) Benjamin D. Elder et al.   JOURNAL OF ORTHOPAEDIC RESEARCH