Polygenic Scores in Psychiatry: On the Road From Discovery to Implementation

A tool for translating polygenic scores onto the absolute scale using summary statistics

(2022) Oliver Pain et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A roadmap to increase diversity in genomic studies

(2022) Segun Fatumo et al.   NATURE MEDICINE

Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study

(2022) Victoria Rodriguez et al.   PSYCHOLOGICAL MEDICINE

Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia

(2022) Antonio F. Pardiñas et al.   JAMA Psychiatry

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

(2022) Vassily Trubetskoy et al.   NATURE

Improving polygenic prediction in ancestrally diverse populations

(2022) Yunfeng Ruan et al.   NATURE GENETICS

Transferability of genetic risk scores in African populations

(2022) Abram B. Kamiza et al.   NATURE MEDICINE

Copy Number Variant Risk Scores Associated With Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort

(2022) Aaron Alexander-Bloch et al.   JAMA Psychiatry

Personalised Risk Prediction in Hereditary Breast and Ovarian Cancer: A Protocol for a Multi-Centre Randomised Controlled Trial

(2022) Stephanie Archer et al.   Cancers

Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses

(2021) Luanluan Sun et al.   PLOS MEDICINE

Risk of Early-Onset Depression Associated With Polygenic Liability, Parental Psychiatric History, and Socioeconomic Status

(2021) Esben Agerbo et al.   JAMA Psychiatry

Establishing a clinical service to prevent psychosis: What, how and when? Systematic review

(2021) Gonzalo Salazar de Pablo et al.   Translational Psychiatry

Genetic Testing in Neurodevelopmental Disorders

(2021) Juliann M. Savatt et al.   Frontiers in Pediatrics

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

(2021) Guiyan Ni et al.   BIOLOGICAL PSYCHIATRY

Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

(2021) Chiara Fabbri et al.   MOLECULAR PSYCHIATRY

Evaluation of polygenic prediction methodology within a reference-standardized framework

(2021) Oliver Pain et al.   PLoS Genetics

Family Genetic Risk Scores and the Genetic Architecture of Major Affective and Psychotic Disorders in a Swedish National Sample

(2021) Kenneth S. Kendler et al.   JAMA Psychiatry

Prognostic value of polygenic risk scores for adults with psychosis

(2021) Isotta Landi et al.   NATURE MEDICINE

Discovery and implications of polygenicity of common diseases

(2021) Peter M. Visscher et al.   SCIENCE

Improved genetic prediction of complex traits from individual-level data or summary statistics

(2021) Qianqian Zhang et al.   Nature Communications

Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I)

(2021) Jennifer Brooks et al.   Journal of Personalized Medicine

The Australian Genetics of Depression Study: New Risk Loci and Dissecting Heterogeneity Between Subtypes

(2021) Brittany L. Mitchell et al.   BIOLOGICAL PSYCHIATRY

Association Between Genetic Risk for Psychiatric Disorders and the Probability of Living in Urban Settings

(2021) Jessye M. Maxwell et al.   JAMA Psychiatry

Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness

(2021) Jurjen J. Luykx et al.   BIOLOGICAL PSYCHIATRY

Predictive Accuracy of a Polygenic Risk Score–Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease

(2020) Joshua Elliott et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion

(2020) Isabelle Cleynen et al.   MOLECULAR PSYCHIATRY

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

(2020) Jonathan R. I. Coleman et al.   MOLECULAR PSYCHIATRY

Polygenic risk scores: from research tools to clinical instruments

(2020) Cathryn M. Lewis et al.   Genome Medicine

Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals

(2020) Wonuola A. Akingbuwa et al.   JAMA Psychiatry

Polygenic Risk and Progression to Bipolar or Psychotic Disorders Among Individuals Diagnosed With Unipolar Depression in Early Life

(2020) Katherine L. Musliner et al.   AMERICAN JOURNAL OF PSYCHIATRY

Depression with atypical neurovegetative symptoms shares genetic predisposition with immuno-metabolic traits and alcohol consumption

(2020) Isabella Badini et al.   PSYCHOLOGICAL MEDICINE

Could Polygenic Risk Scores Be Useful in Psychiatry?

(2020) Graham K. Murray et al.   JAMA Psychiatry

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

(2019) Andrew Lee et al.   GENETICS IN MEDICINE

Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population

(2019) Katherine L. Musliner et al.   JAMA Psychiatry

Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda

(2019) Anne Stevenson et al.   BMJ Open

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

PRSice-2: Polygenic Risk Score software for biobank-scale data

(2019) Shing Wan Choi et al.   GigaScience

Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications

(2019) Rashelle J. Musci et al.   Current Psychiatry Reports

Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk

(2019) Diana O. Perkins et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations

(2019) Roseann E. Peterson et al.   CELL

Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry

(2019) Tim B. Bigdeli et al.   MOLECULAR PSYCHIATRY

Improved polygenic prediction by Bayesian multiple regression on summary statistics

(2019) Luke R. Lloyd-Jones et al.   Nature Communications

Schizophrenia polygenic risk score and 20-year course of illness in psychotic disorders

(2019) Katherine G. Jonas et al.   Translational Psychiatry

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia

(2018) Sarah E. Bergen et al.   AMERICAN JOURNAL OF PSYCHIATRY

Prospects for using risk scores in polygenic medicine

(2017) Cathryn M. Lewis et al.   Genome Medicine

Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations

(2017) Yuri Milaneschi et al.   JAMA Psychiatry

Meta-analysis of the heritability of human traits based on fifty years of twin studies

(2015) Tinca J C Polderman et al.   NATURE GENETICS

Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia

(2015) Esben Agerbo et al.   JAMA Psychiatry

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Power and Predictive Accuracy of Polygenic Risk Scores

(2013) Frank Dudbridge   PLoS Genetics

Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses

(2011) P M Visscher et al.   MOLECULAR PSYCHIATRY

Penetrance for copy number variants associated with schizophrenia

(2010) E. Vassos et al.   HUMAN MOLECULAR GENETICS

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Familial risks of psychotic disorders and schizophrenia among siblings based on hospitalizations in Sweden

(2009) Xinjun Li et al.   PSYCHIATRY RESEARCH

Psychiatric family history and schizophrenia risk in Denmark: which mental disorders are relevant?

(2009) P. B. Mortensen et al.   PSYCHOLOGICAL MEDICINE

Gene-Environment Interactions in Schizophrenia: Review of Epidemiological Findings and Future Directions

(2008) J. van Os et al.   SCHIZOPHRENIA BULLETIN