Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis

Mesenchymal stromal cells plus basiliximab, calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter, randomized, phase 3, open-label trial

(2022) Ke Zhao et al.   Journal of Hematology & Oncology

Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition

(2021) Yan Zhang et al.   Stem Cell Research & Therapy

Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

(2020) Meadhbh Á. Brennan et al.   ADVANCED FUNCTIONAL MATERIALS

The Fibroblast-Like Synoviocyte Derived Exosomal Long Non-coding RNA H19 Alleviates Osteoarthritis Progression Through the miR-106b-5p/TIMP2 Axis

(2020) Fengjin Tan et al.   INFLAMMATION

Exosomes derived from miRNA-210 overexpressing bone marrow mesenchymal stem cells protect lipopolysaccharide induced chondrocytes injury via the NF-κB pathway

(2020) Lei He et al.   GENE

Exosomes derived from miR-155-5p–overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes

(2020) Zhirong Wang et al.   CELL BIOLOGY AND TOXICOLOGY

Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration

(2020) Xiao Xu et al.   BIOMATERIALS

Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes

(2019) Enrico Ragni et al.   Stem Cell Research & Therapy

Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial

(2019) Julien Freitag et al.   Regenerative Medicine

Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways

(2019) Hui Qi et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Osteoarthritis

(2019) David J Hunter et al.   LANCET

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

Long-term Evaluation of Allogeneic Bone Marrow-derived Mesenchymal Stromal Cell Therapy for Crohn’s Disease Perianal Fistulas

(2019) Marieke C Barnhoorn et al.   Journal of Crohns & Colitis

Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate‐induced animal model of osteoarthritis

(2019) Manuela Zavatti et al.   BIOFACTORS

Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity

(2019) Litao Yan et al.   CELL BIOLOGY AND TOXICOLOGY

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study

(2018) D. Kuah et al.   Journal of Translational Medicine

Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

(2018) Yang Song et al.   Regenerative Medicine

Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells

(2018) Hao Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

(2018) Guping Mao et al.   Stem Cell Research & Therapy

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

(2018) Yubao Liu et al.   BIOCHEMICAL JOURNAL

MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis

(2018) Yubao Liu et al.   CELL CYCLE

TGF-β1 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b

(2018) Rui Wang et al.   CELL CYCLE

Safety and efficacy of allogenic placental mesenchymal stem cells for treating knee osteoarthritis: a pilot study

(2018) SHAYESTEH KHALIFEH SOLTANI et al.   CYTOTHERAPY

In-vitro chondrogenic potential of synovial stem cells and chondrocytes allocated for autologous chondrocyte implantation — a comparison

(2017) Eva Johanna Kubosch et al.   INTERNATIONAL ORTHOPAEDICS

Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production

(2017) J. Michael Sorrell et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts

(2017) Miguel Tofiño-Vian et al.   Oxidative Medicine and Cellular Longevity

Allogeneic MSCs and Recycled Autologous Chondrons Mixed in a One-Stage Cartilage Cell Transplantion: A First-in-Man Trial in 35 Patients

(2017) Tommy S. de Windt et al.   STEM CELLS

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

(2017) Yu Zhu et al.   Stem Cell Research & Therapy

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

(2017) Yafei Wang et al.   Stem Cell Research & Therapy

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study

(2017) Mahasen Al-Najar et al.   Journal of Orthopaedic Surgery and Research

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

Adipose-Derived Mesenchymal Stem Cells With Microfracture Versus Microfracture Alone: 2-Year Follow-up of a Prospective Randomized Trial

(2016) Yong-Gon Koh et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Injection of Mesenchymal Stem Cells as a Supplementary Strategy of Marrow Stimulation Improves Cartilage Regeneration After Lateral Sliding Calcaneal Osteotomy for Varus Ankle Osteoarthritis: Clinical and Second-Look Arthroscopic Results

(2016) Yong Sang Kim et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)

(2016) José M. Lamo-Espinosa et al.   Journal of Translational Medicine

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

(2016) S. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Adipose-derived mesenchymal stem cells and platelet-rich plasma synergistically ameliorate the surgical-induced osteoarthritis in Beagle dogs

(2016) Sungho Yun et al.   Journal of Orthopaedic Surgery and Research

Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up

(2016) Yong-Beom Park et al.   Stem Cells Translational Medicine

Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial

(2016) Yves-Marie Pers et al.   Stem Cells Translational Medicine

The Prevalence of Symptomatic Knee Osteoarthritis in China: Results From the China Health and Retirement Longitudinal Study

(2016) Xu Tang et al.   Arthritis & Rheumatology

Allogeneic Mesenchymal Stem Cells in Combination with Hyaluronic Acid for the Treatment of Osteoarthritis in Rabbits

(2016) En-Rung Chiang et al.   PLoS One

Mesenchymal stem cell therapy for knee osteoarthritis: 5 years follow-up of three patients

(2015) Fereydoun Davatchi et al.   International Journal of Rheumatic Diseases

Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells

(2015) Aurelio Vega et al.   TRANSPLANTATION

Second-Look Arthroscopic Evaluation of Cartilage Lesions After Mesenchymal Stem Cell Implantation in Osteoarthritic Knees

(2014) Yong Gon Koh et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Matrix-induced autologous mesenchymal stem cell implantation versus matrix-induced autologous chondrocyte implantation in the treatment of chondral defects of the knee: a 2-year randomized study

(2014) Isık Akgun et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

Effect of self-assembled peptide–mesenchymal stem cell complex on the progression of osteoarthritis in a rat model

(2014) Sang Jun Kim et al.   International Journal of Nanomedicine

Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy

(2014) C Thomas Vangsness et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial

(2014) Chris Hyunchul Jo et al.   STEM CELLS

Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility

(2014) Tokiko Nagamura-Inoue   World Journal of Stem Cells

Clinical Outcomes of Mesenchymal Stem Cell Injection With Arthroscopic Treatment in Older Patients With Osteochondral Lesions of the Talus

(2013) Yong Sang Kim et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Adipose-Derived Mesenchymal Stem Cells Exert Antiinflammatory Effects on Chondrocytes and Synoviocytes From Osteoarthritis Patients Through Prostaglandin E2

(2013) Cristina Manferdini et al.   ARTHRITIS AND RHEUMATISM

Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis

(2013) Yong-Gon Koh et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months

(2010) Shigeyuki Wakitani et al.   Journal of Tissue Engineering and Regenerative Medicine

The Clinical Use of Human Culture–Expanded Autologous Bone Marrow Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects

(2010) Amgad M. Haleem et al.   Cartilage

Collagen scaffolds for tissue engineering

(2007) Julie Glowacki et al.   BIOPOLYMERS