Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury

Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options

(2022) Xiaopeng Cai et al.   Journal of Zhejiang University-SCIENCE B

Helper T Cell (CD4+) Targeted Tacrolimus Delivery Mediates Precise Suppression of Allogeneic Humoral Immunity

(2022) Jia Shen et al.   Research

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

(2021) Jiucui Li et al.   Journal of Translational Medicine

Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury

(2021) Baolin Niu et al.   CELL BIOLOGY AND TOXICOLOGY

Dual stimuli-responsive fungicide carrier based on hollow mesoporous silica/hydroxypropyl cellulose hybrid nanoparticles

(2021) Yunhao Gao et al.   JOURNAL OF HAZARDOUS MATERIALS

Astaxanthin: A super antioxidant from microalgae and its therapeutic potential

(2021) Satish Kumar et al.   JOURNAL OF BASIC MICROBIOLOGY

Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway

(2020) Gengyuan Cui et al.   Oxidative Medicine and Cellular Longevity

Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure

(2020) Hartmut Jaeschke et al.   TOXICOLOGICAL SCIENCES

Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

(2020) Ranjith Kumar Kankala et al.   ADVANCED MATERIALS

Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

(2020) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Hollow Mesoporous Silica Nanoparticles with Extra-Large Mesopores for Enhanced Cancer Vaccine

(2020) Jun Yup Lee et al.   ACS Applied Materials & Interfaces

Ischemic postconditioning attenuates acute kidney injury following intestinal ischemia‐reperfusion through Nrf2‐regulated autophagy, anti‐oxidation, and anti‐inflammation in mice

(2020) Rong Chen et al.   FASEB JOURNAL

Ferroptosis in Liver Diseases: An Overview

(2020) Martina Maria Capelletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence

(2020) Ramesh Kumar Saini et al.   PHARMACOLOGICAL RESEARCH

Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice

(2020) Lu Yuan et al.   FOOD AND CHEMICAL TOXICOLOGY

(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis

(2020) Min Wang et al.   Cell Death & Disease

Research mechanisms of and pharmaceutical treatments for ferroptosis in liver diseases

(2020) Jun Yu et al.   BIOCHIMIE

Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions

(2020) Ming Xian Chang et al.   MOLECULES

Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities

(2019) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Radiopharmaceuticals and Fluorescein Sodium Mediated Triple‐Modality Molecular Imaging Allows Precise Image‐Guided Tumor Surgery

(2019) Sheng Zheng et al.   Advanced Science

Acute liver failure

(2019) R Todd Stravitz et al.   LANCET

Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway

(2019) Weixiang Xu et al.   Toxins

Role and mechanisms of autophagy in acetaminophen-induced liver injury

(2018) Xiaojuan Chao et al.   LIVER INTERNATIONAL

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

(2018) Anna Moles et al.   Frontiers in Pharmacology

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

(2018) Mingzhu Yan et al.   Redox Biology

Mesoporous silica nanoparticles for drug and gene delivery

(2018) Yixian Zhou et al.   Acta Pharmaceutica Sinica B

Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity

(2018) Ji Hye Han et al.   Scientific Reports

Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma

(2017) Huiying Xue et al.   International Journal of Nanomedicine

Quantitative and correlative biodistribution analysis of 89Zr-labeled mesoporous silica nanoparticles intravenously injected into tumor-bearing mice

(2017) Larissa Kramer et al.   Nanoscale

The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy

(2017) Dongwei Xu et al.   Cell Death & Disease

Outcomes in Adults With Acute Liver Failure Between 1998 and 2013

(2016) Adrian Reuben et al.   ANNALS OF INTERNAL MEDICINE

Hollow mesoporous silica nanoparticles facilitated drug delivery via cascade pH stimuli in tumor microenvironment for tumor therapy

(2016) Junjie Liu et al.   BIOMATERIALS

Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system

(2016) Chun Pang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

(2016) Bharat Bhushan et al.   TOXICOLOGICAL SCIENCES

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis

(2015) Jingjing Li et al.   PLoS One

Hollow-Structured Mesoporous Materials: Chemical Synthesis, Functionalization and Applications

(2014) Yongsheng Li et al.   ADVANCED MATERIALS

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Astaxanthin lowers plasma TAG concentrations and increases hepatic antioxidant gene expression in diet-induced obesity mice

(2014) Yue Yang et al.   BRITISH JOURNAL OF NUTRITION

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

(2014) Ranga Ambati et al.   Marine Drugs

Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy

(2014) Miao Shen et al.   MEDIATORS OF INFLAMMATION

Synthesis of mesoporous silica nanoparticles

(2013) Si-Han Wu et al.   CHEMICAL SOCIETY REVIEWS

Influence of Geometry, Porosity, and Surface Characteristics of Silica Nanoparticles on Acute Toxicity: Their Vasculature Effect and Tolerance Threshold

(2012) Tian Yu et al.   ACS Nano

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Mesoporous Silica Nanoparticles for Increasing the Oral Bioavailability and Permeation of Poorly Water Soluble Drugs

(2012) Yanzhuo Zhang et al.   MOLECULAR PHARMACEUTICS

Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles

(2011) Yu Gao et al.   ACS Nano

Under the ROS: Thiol network is the principal suspect for autophagy commitment

(2010) Giuseppe Filomeni et al.   Autophagy

Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals

(2010) Jie Lu et al.   Small

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose

(2009) Nasrin Pakravan et al.   CLINICAL TOXICOLOGY

Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug-Resistant Cancer Cells

(2009) Alex M. Chen et al.   Small

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS