Article
Chemistry, Multidisciplinary
Zhengze Lu, Yang Long, Jiaxin Li, Kebai Ren, Wei Zhao, Xuhui Wang, Chunyu Xia, Yashi Wang, Man Li, Zhirong Zhang, Qin He
Summary: The developed LA/DOX NP can inhibit inflammatory cell recruitment in the liver and lungs through multiple mechanisms, block NF-kappa B and STAT3 signaling pathways, thereby shutting down inflammatory feed-forward loops, providing a new therapeutic strategy for breast cancer and its metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Medicine, Research & Experimental
Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian
Summary: This study summarizes the anti-inflammatory efficacy of astaxanthin in various chronic and acute disorders, as well as the pathways through which it mediates its effects. Further experimental and clinical studies are needed to confirm the anti-inflammatory and protective effects of astaxanthin in humans. The review suggests that astaxanthin, with its demonstrated anti-inflammatory properties, may be a suitable candidate for drug design with novel technology.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Xiaowen Bi, Baolin Jiang, Jinyi Zhou, Xirui Fan, Xintong Yan, Juanjuan Liang, Lan Luo, Zhimin Yin
Summary: Inhibition of CBP bromodomain effectively blocks HMGB1-mediated inflammatory responses and reduces its pro-inflammatory activity. SGC-CBP30 down-regulates the activation of relevant signaling pathways to decrease the inflammatory effects of HMGB1.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wan Li, Zhengnan Cai, Florian Schindler, Sheyda Bahiraii, Martin Brenner, Elke H. Heiss, Wolfram Weckwerth
Summary: This study aimed to investigate the preventive effects of norbergenin on LPS-induced proinflammatory signaling in macrophages and elucidate the underlying mechanisms. It was found that norbergenin alleviated LPS-induced production of inflammatory factors in macrophages by suppressing the activation of TLR2 mediated signaling pathways. Furthermore, norbergenin regulated metabolic reprogramming in LPS-stimulated macrophages, promoting OXPHOS and restoring aberrant metabolites within the TCA cycle.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jaeeun Lee, Min-Hyun Kim, Hyeyoung Kim
Summary: A moderate amount of ROS plays an important role in cell signaling and immune response, while excessive production can lead to inflammation and pathological conditions. The gastrointestinal mucosa is continuously exposed to ROS, increasing the risk of GI disorders. AST, a compound with antioxidant and anti-inflammatory properties, has shown protective effects against GI diseases through various mechanisms, including ROS neutralization, enhancement of antioxidant enzyme activity, and suppression of inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zhouke Tan, Qianqian Liu, Hongjun Chen, Ziyang Zhang, Qin Wang, Yingsong Mu, Yiman Li, TingTing Hu, Yibin Yang, Xiaoyong Yan
Summary: Sepsis-associated acute kidney injury (AKI) is a common and deadly disease without effective therapy. In this study, pectolinarigenin showed significant improvement in septic AKI by reducing inflammation and restoring mitochondrial function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Green & Sustainable Science & Technology
Kai Wang, Chundong Yang, Xin Xu, Chenhuan Lai, Daihui Zhang, Qiang Yong
Summary: In this study, ethanol organosolv lignins were used as representatives of surface lignins, and the effects of adding 2-naphthol in organosolv pretreatment were investigated. The results showed that 2-naphthol modification remarkably eliminated the negative effects of lignins and promoted enzymatic hydrolysis.
Article
Pharmacology & Pharmacy
Mengting Zhang, Wanhong Wu, Caoxin Huang, Teng Cai, Nengjiang Zhao, Suhuan Liu, Shuyu Yang
Summary: This study investigated the effects and mechanisms of the traditional Chinese medicine formula SX-1 in treating chronic stress-induced depression and liver injury. The results showed that SX-1 effectively ameliorated depression-like behaviors and hepatic injuries caused by chronic stress, possibly through the blockade of hepatic IL-6/JAK2/STAT3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Yinyan Yin, Nuo Xu, Tao Qin, Bangyue Zhou, Yi Shi, Xinyi Zhao, Bixia Ma, Zhengzhong Xu, Chunmei Li
Summary: The study showed that astaxanthin exhibits strong antioxidant properties by increasing cellular reductive status, upregulating antioxidant enzyme activities, and inhibiting cytokine secretions, which could potentially alleviate DC-related inflammatory responses and serve as a promising approach for sepsis treatment.
Article
Cell Biology
Chunhui Zhu, Gang Liu, Weiding Cui, Zhongjie Yu, Wei Chen, Yao Qin, Jiuxiang Liu, Yaojun Lu, Weimin Fan, Wenwei Liang
Summary: The Rspo2 gene is elevated in synovial tissues of osteoarthritis (OA) patients. In this study, we found that astaxanthin and Rspo2 have therapeutic effects on OA. Astaxanthin can reverse the increase in inflammatory factors and decrease in anabolic markers, as well as suppress the secretion of Rspo2.
Article
Medicine, Research & Experimental
Minling Pan, Zhen Wang, Yiyi Wang, Xianqin Jiang, Yali Fan, Fanghua Gong, Yunpeng Sun, Dezhong Wang
Summary: Ferroptosis is a crucial process in AKI that can lead to CKD and ESRD. Celastrol, an active ingredient of Tripterygium wilfordii, has anti-inflammatory and anti-cancer effects. This study found that celastrol protected against cisplatin-induced AKI by reducing inflammation, oxidative stress, renal iron accumulation, and ferroptosis. Mechanistic analysis revealed that celastrol upregulated GPX4 via Nrf2, alleviating ferroptosis and reducing LDH release, intracellular iron accumulation, and lipid peroxidation. These findings suggest the potential use of celastrol for treating AKI associated with ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Sung Li, Shih-Chao Lin, Chien-Hui Chu, Yu-Kang Chang, Xiang Zhang, Chi-Chien Lin, Yu-Tang Tung
Summary: Naringenin exhibits anti-inflammatory and antioxidant properties, protecting the gastric mucosa in ethanol-induced damage models by reducing inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
James T. O'Connor, Aaron C. Stevens, Erica K. Shannon, Fabiha Bushra Akbar, Kimberly S. LaFever, Neil P. Narayanan, Casey D. Gailey, M. Shane Hutson, Andrea Page-McCaw
Summary: Research shows that wounds in the Drosophila notum trigger an increase in cytoplasmic calcium by activating extracellular cytokines Gbps, which then signal surrounding epithelial cells through Mthl10 receptors.
DEVELOPMENTAL CELL
(2021)
Article
Andrology
Oladele Afolabi, Babatunde Alabi, Temidayo Omobowale, Olufemi Oluranti, Olugbenga Iwalewa
Summary: The study found that cysteamine plays an antioxidant, anti-inflammatory, and anti-apoptotic role in testicular torsion/detorsion reperfusion injury. Cysteamine reversed the oxidative stress, inflammation markers, and reduced sperm motility seen in IRI rats. Additionally, cysteamine inhibited apoptosis in the testicular tissue, providing protection against reperfusion injury.
Article
Immunology
Keyvan Amirshahrokhi, Ali Niapour
Summary: Excessive ethanol consumption can cause brain injury, but this study found that methylsulfonylmethane (MSM) has a protective effect against ethanol-induced brain injury. MSM reduces oxidative stress and inflammation, increases antioxidant levels, and decreases apoptosis-related proteins. These findings suggest that MSM may be a potential approach to prevent brain damage caused by high levels of alcohol.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)