Genomic insights into ayurvedic and western approaches to personalized medicine

Combined genetic effects of EGLN1 and VWF modulate thrombotic outcome in hypoxia revealed by Ayurgenomics approach

(2015) Shilpi Aggarwal et al.   Journal of Translational Medicine

Widespread seasonal gene expression reveals annual differences in human immunity and physiology

(2015) Xaquin Castro Dopico et al.   Nature Communications

Hematological, Hepatic, and Retinal Phenotypes in Mice Deficient for Prolyl Hydroxylase Domain Proteins in the Liver

(2014) Li-Juan Duan et al.   AMERICAN JOURNAL OF PATHOLOGY

HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells

(2014) Nobuyuki Fujita et al.   FASEB JOURNAL

Conditional Disruption of the Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Defines Its Key Role in Skeletal Development

(2014) Shaohong Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prolyl hydroxylase domain-2 (PHD2) inhibition may be a better therapeutic strategy in renal anemia

(2014) Hitesh Soni   MEDICAL HYPOTHESES

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Natural selection and infectious disease in human populations

(2014) Elinor K. Karlsson et al.   NATURE REVIEWS GENETICS

Complexity and network dynamics in physiological adaptation: An integrated view

(2014) György Baffy et al.   PHYSIOLOGY & BEHAVIOR

A simulation study of gene-by-environment interactions in GWAS implies ample hidden effects

(2014) Urko M. Marigorta et al.   Frontiers in Genetics

Andean and Tibetan patterns of adaptation to high altitude

(2013) Abigail W. Bigham et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Selection and Adaptation in the Human Genome

(2013) Wenqing Fu et al.   Annual Review of Genomics and Human Genetics

Genetic Interaction Networks: Toward an Understanding of Heritability

(2013) Anastasia Baryshnikova et al.   Annual Review of Genomics and Human Genetics

Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases

(2013) Vaithinathan Selvaraju et al.   ANTIOXIDANTS & REDOX SIGNALING

Erythrocytosis: the HIF pathway in control

(2013) K. Franke et al.   BLOOD

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

Prolyl Hydroxylase Domain Protein 2 Plays a Critical Role in Diet-Induced Obesity and Glucose Intolerance

(2013) Hirohide Matsuura et al.   CIRCULATION

Hypoxia Inducible Factor Stabilization As a Novel Strategy to Treat Anemia

(2013) S. Zhao et al.   CURRENT MEDICINAL CHEMISTRY

Robustness and Epistasis in the C. elegans Vulval Signaling Network Revealed by Pathway Dosage Modulation

(2013) Michalis Barkoulas et al.   DEVELOPMENTAL CELL

A dynamic model of the hypoxia-inducible factor 1  (HIF-1 ) network

(2013) L. K. Nguyen et al.   JOURNAL OF CELL SCIENCE

Loss of Epithelial Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Accelerates Skin Wound Healing in Mice

(2013) Joanna Kalucka et al.   MOLECULAR AND CELLULAR BIOLOGY

The big challenges of big data

(2013) Vivien Marx   NATURE

Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans

(2013) E. C.-P. Chua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inter-individual differences in response to dietary intervention: integrating omics platforms towards personalised dietary recommendations

(2013) Johanna W. Lampe et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

From personalized to public health genomics

(2013) Greg Gibson et al.   Genome Medicine

What if we had whole-genome sequence data for millions of individuals?

(2013) Peter M Visscher et al.   Genome Medicine

The Conditional Nature of Genetic Interactions: The Consequences of Wild-Type Backgrounds on Mutational Interactions in a Genome-Wide Modifier Screen

(2013) Sudarshan Chari et al.   PLoS Genetics

Blood-Informative Transcripts Define Nine Common Axes of Peripheral Blood Gene Expression

(2013) Marcela Preininger et al.   PLoS Genetics

Paternal Age Effect Mutations and Selfish Spermatogonial Selection: Causes and Consequences for Human Disease

(2012) Anne Goriely et al.   AMERICAN JOURNAL OF HUMAN GENETICS

COPD and the Solar System

(2012) Leonardo M. Fabbri et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia Response in Asthma

(2012) Tanveer Ahmad et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Human Genetic Individuality

(2012) Maynard V. Olson   Annual Review of Genomics and Human Genetics

Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes

(2012) Rui Chen et al.   CELL

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Ancient Admixture in Human History

(2012) N. Patterson et al.   GENETICS

Molecular oxygen sensing: implications for visceral surgery

(2012) Judit Kiss et al.   LANGENBECKS ARCHIVES OF SURGERY

Evolutionary Meta-Analysis of Association Studies Reveals Ancient Constraints Affecting Disease Marker Discovery

(2012) J. T. Dudley et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

(2012) Michael C Turchin et al.   NATURE GENETICS

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

Hypoxia-inducible factor as a therapeutic target for cardioprotection

(2012) Sang-Ging Ong et al.   PHARMACOLOGY & THERAPEUTICS

In Vivo Effects Of Traditional Ayurvedic Formulations in Drosophila melanogaster Model Relate with Therapeutic Applications

(2012) Vibha Dwivedi et al.   PLoS One

Potential of Ayurgenomics Approach in Complex Trait Research: Leads from a Pilot Study on Rheumatoid Arthritis

(2012) Ramesh C. Juyal et al.   PLoS One

Transgenerational epigenetic inheritance: Focus on soma to germline information transfer

(2012) Abhay Sharma   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

HIF–prolyl hydroxylases and cardiovascular diseases

(2012) Sucharita Sen Banerjee et al.   TOXICOLOGY MECHANISMS AND METHODS

Effects of thermal environment on sleep and circadian rhythm

(2012) Kazue Okamoto-Mizuno et al.   Journal of Physiological Anthropology

Ayurgenomics: A New Way of Threading Molecular Variability for Stratified Medicine

(2011) Tav Pritesh Sethi et al.   ACS Chemical Biology

Human Microbiome in Health and Disease

(2011) Kathryn J. Pflughoeft et al.   Annual Review of Pathology-Mechanisms of Disease

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

High altitude adaptation in Daghestani populations from the Caucasus

(2011) Luca Pagani et al.   HUMAN GENETICS

Genetic determinants of Tibetan high-altitude adaptation

(2011) Tatum S. Simonson et al.   HUMAN GENETICS

Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine

(2011) Q. Tian et al.   JOURNAL OF INTERNAL MEDICINE

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

Predictive, personalized, preventive, participatory (P4) cancer medicine

(2011) Leroy Hood et al.   Nature Reviews Clinical Oncology

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

What Does a "Normal" Human Genome Look Like?

(2011) M. V. Olson   SCIENCE

Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations

(2011) Sudhir Kumar et al.   TRENDS IN GENETICS

Systems biology and the future of medicine

(2011) Joseph Loscalzo et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Adaptations to Climate-Mediated Selective Pressures in Humans

(2011) Angela M. Hancock et al.   PLoS Genetics

Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Pressure through Human Evolution

(2011) Matteo Fumagalli et al.   PLoS Genetics

Addressing the Complexity of Chronic Obstructive Pulmonary Disease

(2010) Alvar Agusti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Assessing the human immune system through blood transcriptomics

(2010) Damien Chaussabel et al.   BMC BIOLOGY

Cardiovascular Networks

(2010) Aldons J. Lusis et al.   CIRCULATION

The Human Phenotype Ontology

(2010) PN Robinson et al.   CLINICAL GENETICS

Neo-Darwinism, the Modern Synthesis and selfish genes: are they of use in physiology?

(2010) Denis Noble   JOURNAL OF PHYSIOLOGY-LONDON

Variability in gene expression underlies incomplete penetrance

(2010) Arjun Raj et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda

(2010) S. Aggarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human skin pigmentation as an adaptation to UV radiation

(2010) N. G. Jablonski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Catalog of Reference Genomes from the Human Microbiome

(2010) et al.   SCIENCE

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions

(2009) Gregory J. Kato et al.   AMERICAN JOURNAL OF HEMATOLOGY

Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

(2009) Sarah K. Harten et al.   ANTIOXIDANTS & REDOX SIGNALING

Therapeutic Manipulation of the HIF Hydroxylases

(2009) Simon Nagel et al.   ANTIOXIDANTS & REDOX SIGNALING

Ontology-driven indexing of public datasets for translational bioinformatics

(2009) Nigam H Shah et al.   BMC BIOINFORMATICS

Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?

(2009) Bhushan Patwardhan et al.   DRUG DISCOVERY TODAY

The impact of cellular networks on disease comorbidity

(2009) Juyong Park et al.   Molecular Systems Biology

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Systems medicine: the future of medical genomics and healthcare

(2009) Charles Auffray et al.   Genome Medicine

The Role of Geography in Human Adaptation

(2009) Graham Coop et al.   PLoS Genetics

Environmental epigenomics in human health and disease

(2008) Dana C. Dolinoy et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda

(2008) Bhavana Prasher et al.   Journal of Translational Medicine

The Biphasic Role of the Hypoxia-Inducible Factor Prolyl-4-Hydroxylase, PHD2, in Modulating Tumor-Forming Potential

(2008) K. Lee et al.   MOLECULAR CANCER RESEARCH

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

PHD2Mutation and Congenital Erythrocytosis with Paraganglioma

(2008) Charline Ladroue et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Mouse Genome Database genotypes::phenotypes

(2008) J. A. Blake et al.   NUCLEIC ACIDS RESEARCH

Adaptations to Climate in Candidate Genes for Common Metabolic Disorders

(2008) Angela M. Hancock et al.   PLoS Genetics